Entity Details

Primary name AVR2A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP27037
EntryNameAVR2A_HUMAN
FullNameActivin receptor type-2A
TaxID9606
Evidenceevidence at protein level
Length513
SequenceStatuscomplete
DateCreated1992-08-01
DateModified2021-06-02

Ontological Relatives

GenesACVR2A

GO terms

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GOName
GO:0001702 gastrulation with mouth forming second
GO:0001934 positive regulation of protein phosphorylation
GO:0004674 protein serine/threonine kinase activity
GO:0004675 transmembrane receptor protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006468 protein phosphorylation
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007283 spermatogenesis
GO:0007368 determination of left/right symmetry
GO:0007498 mesoderm development
GO:0009952 anterior/posterior pattern specification
GO:0009986 cell surface
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0015026 coreceptor activity
GO:0019838 growth factor binding
GO:0030165 PDZ domain binding
GO:0030501 positive regulation of bone mineralization
GO:0030509 BMP signaling pathway
GO:0030513 positive regulation of BMP signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0032924 activin receptor signaling pathway
GO:0032927 positive regulation of activin receptor signaling pathway
GO:0034673 inhibin-betaglycan-ActRII complex
GO:0034711 inhibin binding
GO:0042713 sperm ejaculation
GO:0043084 penile erection
GO:0043235 receptor complex
GO:0043621 protein self-association
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0048179 activin receptor complex
GO:0048185 activin binding
GO:0048706 embryonic skeletal system development
GO:0050999 regulation of nitric-oxide synthase activity
GO:0060011 Sertoli cell proliferation
GO:0071363 cellular response to growth factor stimulus
GO:0071773 cellular response to BMP stimulus
GO:0098821 BMP receptor activity

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR000333 Ser/Thr protein kinase, TGFB receptorFamilyFamily
IPR000472 Activin types I and II receptor domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB12118 SotaterceptDrugbankbiotech

Interactions

30 interactions

InteractorPartnerSourcesPublicationsLink
AVR2A_HUMANDAXX_HUMANBioGRID, MINT11483955 details
AVR2A_HUMANBMP2_HUMANBioGRID, DIP18070108 25938661 details
AVR2A_HUMANSYJ2B_HUMANBioGRID, HPRD11882656 15451561 details
AVR2A_HUMANINHBA_HUMANBioGRID, HPRD10746731 11266516 8242742 8389764 9202237 details
AVR2A_HUMANINHBB_HUMANBioGRID, HPRD11266516 28126904 9202237 details
AVR2A_HUMANBMP6_HUMANBioGRID, HPRD10504300 18070108 details
AVR2A_HUMANBMP7_HUMANBioGRID, HPRD12667445 18070108 9748228 details
AVR2A_HUMANMAGI2_HUMANBioGRID, HPRD10681527 15451561 details
AVR2A_HUMANERBIN_HUMANBioGRID15123239 details
AVR2A_HUMANGDF2_HUMANBioGRID17311849 22718755 details
AVR2A_HUMANBMP10_HUMANBioGRID22718755 details
AVR2A_HUMANTSP50_HUMANBioGRID28650473 details
AVR2A_HUMANTDGF1_HUMANBioGRID28126904 details
AVR2A_HUMANNODAL_HUMANBioGRID28126904 details
AVR2A_HUMANBMP4_HUMANBioGRID28126904 details
AVR2A_HUMANDYLT4_HUMANHPRD16982625 details
AVR2A_HUMANINHA_HUMANBioGRID10746731 details
AVR2A_HUMANGDF5_HUMANBioGRID, HPRD8702914 details
AVR2A_HUMANEGLN_HUMANBioGRID, HPRD23967299 9872992 details
AVR2A_HUMANACV1B_HUMANBioGRID11927552 8612709 9892009 details
AVR2A_HUMANIGSF1_HUMANBioGRID, HPRD11266516 details
AVR2A_HUMANPEG10_HUMANBioGRID15611116 details
AVR2A_HUMANACVR1_HUMANBioGRID8242742 details
AVR2A_HUMANRGMB_HUMANBioGRID15671031 details
AVR2A_HUMANBMPR2_HUMANBioGRID23967299 details
AVR2A_HUMANBMR1A_HUMANBioGRID15940369 details
AVR2A_HUMANTGBR3_HUMANHPRD10746731 details
AVR2A_HUMANINHBC_HUMANHPRD12651901 details
AVR2A_HUMANGDF9_HUMANHPRD12135884 details
AVR2A_HUMANACVL1_HUMANHPRD10187774 details