Entity Details

Primary name GRN_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP28799
EntryNameGRN_HUMAN
FullNameProgranulin
TaxID9606
Evidenceevidence at protein level
Length593
SequenceStatuscomplete
DateCreated1992-12-01
DateModified2021-06-02

Ontological Relatives

GenesGRN

GO terms

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GOName
GO:0002265 astrocyte activation involved in immune response
GO:0002282 microglial cell activation involved in immune response
GO:0003723 RNA binding
GO:0005125 cytokine activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0005770 late endosome
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0007040 lysosome organization
GO:0007041 lysosomal transport
GO:0007042 lysosomal lumen acidification
GO:0007165 signal transduction
GO:0008083 growth factor activity
GO:0010595 positive regulation of endothelial cell migration
GO:0016020 membrane
GO:0030335 positive regulation of cell migration
GO:0035578 azurophil granule lumen
GO:0043312 neutrophil degranulation
GO:0043524 negative regulation of neuron apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0045766 positive regulation of angiogenesis
GO:0048680 positive regulation of axon regeneration
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050727 regulation of inflammatory response
GO:0050821 protein stabilization
GO:0051087 chaperone binding
GO:0060266 negative regulation of respiratory burst involved in inflammatory response
GO:0070062 extracellular exosome
GO:0106016 positive regulation of inflammatory response to wounding
GO:1900426 positive regulation of defense response to bacterium
GO:1902564 negative regulation of neutrophil activation
GO:1903334 positive regulation of protein folding
GO:1903979 negative regulation of microglial cell activation
GO:1905247 positive regulation of aspartic-type peptidase activity
GO:1905673 positive regulation of lysosome organization

Subcellular Location

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Subcellular Location
Lysosome
Secreted

Domains

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DomainNameCategoryType
IPR000118 GranulinDomainDomain
IPR037277 Granulin superfamilyFamilyHomologous superfamily
IPR039036 Granulin familyFamilyFamily

Diseases

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Interactions

303 interactions

InteractorPartnerSourcesPublicationsLink
GRN_HUMANHXA1_HUMANBioGRID, HPRD, IntAct, MINT16189514 21653829 25416956 25910212 31515488 32296183 32814053 details
GRN_HUMANP85B_HUMANBioGRID, IntAct21988832 details
GRN_HUMANMCSP_HUMANBioGRID, IntAct32296183 details
GRN_HUMANPDIA1_HUMANBioGRID, IntAct, UniProt26370502 32296183 details
GRN_HUMANKR111_HUMANBioGRID, IntAct32296183 details
GRN_HUMANSYQ_HUMANIntAct32814053 details
GRN_HUMANZN138_HUMANIntAct32814053 details
GRN_HUMANMBD4_HUMANIntAct32814053 details
GRN_HUMANDCAF8_HUMANIntAct32814053 details
GRN_HUMANKLH20_HUMANIntAct32814053 details
GRN_HUMANGGA2B_HUMANIntAct32814053 details
GRN_HUMANPCGF5_HUMANIntAct32814053 details
GRN_HUMANT22D4_HUMANIntAct32814053 details
GRN_HUMANPG12A_HUMANIntAct32814053 details
GRN_HUMANBAP18_HUMANIntAct32814053 details
GRN_HUMANISCA2_HUMANIntAct32814053 details
GRN_HUMANKRA81_HUMANIntAct32814053 details
GRN_HUMANSMAD9_HUMANBioGRID, HPRD, IntAct, MINT15231748 32814053 details
GRN_HUMANPLLP_HUMANBioGRID, IntAct32296183 details
GRN_HUMANTSN4_HUMANBioGRID, IntAct32296183 details
GRN_HUMANKIF1A_HUMANIntAct32814053 details
GRN_HUMANGLI4_HUMANIntAct32814053 details
GRN_HUMANNFX1_HUMANIntAct32814053 details
GRN_HUMANZN180_HUMANIntAct32814053 details
GRN_HUMANFAF1_HUMANIntAct32814053 details
GRN_HUMANKEAP1_HUMANIntAct32814053 details
GRN_HUMANKAD3_HUMANIntAct32814053 details
GRN_HUMANLHX6_HUMANIntAct32814053 details
GRN_HUMANWDR61_HUMANIntAct32814053 details
GRN_HUMANZN524_HUMANIntAct32814053 details
GRN_HUMANH3C_HUMANIntAct32814053 details
GRN_HUMANFAM74_HUMANIntAct32814053 details
GRN_HUMANF111B_HUMANIntAct32814053 details
GRN_HUMANMOGT3_HUMANIntAct32814053 details
GRN_HUMANATX7_HUMANBioGRID, IntAct21078624 details
GRN_HUMANCV039_HUMANBioGRID, IntAct32296183 32814053 details
GRN_HUMANCXCL5_HUMANBioGRID, IntAct32296183 details
GRN_HUMANP2RY6_HUMANIntAct32814053 details
GRN_HUMANMALT1_HUMANIntAct32814053 details
GRN_HUMANPIAS1_HUMANIntAct32814053 details
GRN_HUMANPERP_HUMANIntAct32814053 details
GRN_HUMANKR197_HUMANIntAct32814053 details
GRN_HUMANCCD33_HUMANBioGRID25416956 25910212 32296183 details
GRN_HUMANGFI1B_HUMANBioGRID, HPRD, IntAct16713569 details
GRN_HUMANK1C18_HUMANBioGRID, IntAct21988832 details
GRN_HUMANDLX2_HUMANBioGRID, IntAct25416956 details
GRN_HUMANARFG1_HUMANBioGRID, IntAct25416956 25910212 details
GRN_HUMANKR108_HUMANBioGRID, IntAct32296183 details
GRN_HUMANCRTP1_HUMANBioGRID, IntAct32296183 details
GRN_HUMANKRA59_HUMANBioGRID, IntAct32296183 details
GRN_HUMANKRA62_HUMANBioGRID, IntAct32296183 details
GRN_HUMANBAK_HUMANIntAct32814053 details
GRN_HUMANRN112_HUMANIntAct32814053 details
GRN_HUMANYIF1A_HUMANIntAct32814053 details
GRN_HUMANNR1D2_HUMANIntAct32814053 details
GRN_HUMANFBW1A_HUMANIntAct32814053 details
GRN_HUMANPKHG4_HUMANIntAct32814053 details
GRN_HUMANNGEF_HUMANIntAct32814053 details
GRN_HUMANCX038_HUMANIntAct32814053 details
GRN_HUMANZN774_HUMANIntAct32814053 details
GRN_HUMANCRKL_HUMANBioGRID, IntAct, UniProt18654987 26370502 details
GRN_HUMANSGTA_HUMANBioGRID, IntAct25416956 25910212 31515488 details
GRN_HUMANKR261_HUMANBioGRID, IntAct25416956 25910212 31515488 details
GRN_HUMANLCE4A_HUMANBioGRID, IntAct32296183 details
GRN_HUMANLCE3E_HUMANBioGRID, IntAct32296183 details
GRN_HUMANUTP23_HUMANBioGRID, IntAct32296183 details
GRN_HUMANFA76B_HUMANBioGRID, IntAct32296183 32814053 details
GRN_HUMANPSB8_HUMANIntAct32814053 details
GRN_HUMANZSC9_HUMANIntAct32814053 details
GRN_HUMANTEAD1_HUMANIntAct32814053 details
GRN_HUMANBECN1_HUMANIntAct32814053 details
GRN_HUMANSUMF2_HUMANIntAct32814053 details
GRN_HUMANTASO2_HUMANIntAct32814053 details
GRN_HUMANFBH1_HUMANIntAct32814053 details
GRN_HUMANPGRP3_HUMANIntAct32814053 details
GRN_HUMANZN497_HUMANIntAct32814053 details
GRN_HUMANGLRX3_HUMANBioGRID, IntAct, MINT21516116 25416956 25910212 29892012 31515488 details
GRN_HUMANSORT_HUMANDIP, MINT23236149 24070898 details
GRN_HUMANOTX1_HUMANBioGRID, IntAct25416956 25910212 31515488 32296183 details
GRN_HUMANKRT34_HUMANBioGRID, IntAct32296183 details
GRN_HUMANKR151_HUMANBioGRID, IntAct32296183 details
GRN_HUMANNUFP2_HUMANBioGRID, IntAct, MINT21653829 32296183 32814053 details
GRN_HUMANDMRT3_HUMANBioGRID, IntAct32296183 details
GRN_HUMANZKSC8_HUMANIntAct32814053 details
GRN_HUMANVDAC2_HUMANIntAct32814053 details
GRN_HUMANSNR40_HUMANIntAct32814053 details
GRN_HUMANRYBP_HUMANIntAct32814053 details
GRN_HUMANOTUB1_HUMANIntAct32814053 details
GRN_HUMANASIC4_HUMANIntAct32814053 details
GRN_HUMANZN366_HUMANIntAct32814053 details
GRN_HUMANF131C_HUMANBioGRID, HPRD, IntAct16189514 32814053 details
GRN_HUMANTYY1_HUMANBioGRID, IntAct21988832 32814053 details
GRN_HUMANTGM2_HUMANBioGRID, IntAct21988832 details
GRN_HUMANGLCNE_HUMANBioGRID, IntAct32296183 32814053 details
GRN_HUMANCLPP_HUMANBioGRID, IntAct32296183 details
GRN_HUMANIL16_HUMANIntAct32814053 details
GRN_HUMANGATA1_HUMANIntAct32814053 details
GRN_HUMANSEM1_HUMANIntAct32814053 details
GRN_HUMANBRK1_HUMANIntAct32814053 details
GRN_HUMANZBT24_HUMANIntAct32814053 details
GRN_HUMANCREB5_HUMANIntAct32814053 details
GRN_HUMANKLF15_HUMANIntAct32814053 details
GRN_HUMANBPEC1_HUMANIntAct32814053 details
GRN_HUMANSCAM4_HUMANIntAct32814053 details
GRN_HUMANZN670_HUMANIntAct32814053 details
GRN_HUMANLHX8_HUMANIntAct32814053 details
GRN_HUMANTRIB3_HUMANBioGRID18276110 details
GRN_HUMANAAKB2_HUMANBioGRID, IntAct21988832 32814053 details
GRN_HUMANFRAT1_HUMANBioGRID, IntAct21988832 details
GRN_HUMANDNSL1_HUMANIntAct32814053 details
GRN_HUMANSDC2_HUMANIntAct32814053 details
GRN_HUMANPER1_HUMANIntAct32814053 details
GRN_HUMANZN239_HUMANIntAct32814053 details
GRN_HUMANRBM14_HUMANIntAct32814053 details
GRN_HUMANSEPT6_HUMANIntAct32814053 details
GRN_HUMANTRNT1_HUMANIntAct32814053 details
GRN_HUMANSEM4G_HUMANIntAct32814053 details
GRN_HUMANES8L2_HUMANIntAct32814053 details
GRN_HUMANGPSM3_HUMANIntAct32814053 details
GRN_HUMANZN641_HUMANIntAct32814053 details
GRN_HUMANZN296_HUMANIntAct32814053 details
GRN_HUMANSPAT8_HUMANIntAct32814053 details
GRN_HUMANIQCF2_HUMANIntAct32814053 details
GRN_HUMANGP141_HUMANIntAct32814053 details
GRN_HUMANTOP3B_HUMANBioGRID, HPRD11549288 details
GRN_HUMANMEOX2_HUMANBioGRID32296183 details
GRN_HUMANCAC1A_HUMANBioGRID, IntAct21078624 details
GRN_HUMANCCNG1_HUMANBioGRID, IntAct21988832 details
GRN_HUMANKR132_HUMANBioGRID, IntAct32296183 details
GRN_HUMANKRA61_HUMANBioGRID, IntAct32296183 details
GRN_HUMANKRA15_HUMANBioGRID, IntAct32296183 details
GRN_HUMANMAX_HUMANIntAct32814053 details
GRN_HUMANATTY_HUMANBioGRID, IntAct12588988 32814053 details
GRN_HUMANTAXB1_HUMANIntAct32814053 details
GRN_HUMANSMUF1_HUMANIntAct32814053 details
GRN_HUMANPHF7_HUMANIntAct32814053 details
GRN_HUMANRN208_HUMANIntAct32814053 details
GRN_HUMANKR133_HUMANIntAct32814053 details
GRN_HUMANPOTE1_HUMANBioGRID, IntAct21988832 details
GRN_HUMANRAC1_HUMANBioGRID, IntAct21988832 details
GRN_HUMANNLK_HUMANBioGRID, IntAct25416956 25910212 31515488 details
GRN_HUMANLCE1D_HUMANBioGRID, IntAct32296183 details
GRN_HUMANCRCT1_HUMANBioGRID, IntAct32296183 details
GRN_HUMANTRI35_HUMANIntAct32814053 details
GRN_HUMANDLK1_HUMANBioGRID, HPRD, IntAct11846389 32814053 details
GRN_HUMANRT17_HUMANIntAct32814053 details
GRN_HUMANCA216_HUMANIntAct32814053 details
GRN_HUMANLCA5L_HUMANIntAct32814053 details
GRN_HUMANASB9_HUMANIntAct32814053 details
GRN_HUMANTEX19_HUMANIntAct32814053 details
GRN_HUMANFAM9A_HUMANIntAct32814053 details
GRN_HUMANCL074_HUMANIntAct32814053 details
GRN_HUMANCCNT1_HUMANBioGRID, HPRD12588988 details
GRN_HUMANKR107_HUMANBioGRID, IntAct25416956 details
GRN_HUMANKRA11_HUMANBioGRID, IntAct32296183 details
GRN_HUMANLCE1A_HUMANBioGRID, IntAct32296183 details
GRN_HUMANMNDA_HUMANIntAct32814053 details
GRN_HUMANIRAG1_HUMANIntAct32814053 details
GRN_HUMANASB3_HUMANIntAct32814053 details
GRN_HUMANCIA2B_HUMANIntAct32814053 details
GRN_HUMANLOXL4_HUMANIntAct32814053 details
GRN_HUMANCNST_HUMANIntAct32814053 details
GRN_HUMANFANCL_HUMANBioGRID, IntAct25416956 details
GRN_HUMANIG2R_HUMANIntAct32814053 details
GRN_HUMANGATA2_HUMANIntAct32814053 details
GRN_HUMANM3K5_HUMANIntAct32814053 details
GRN_HUMANMS18B_HUMANIntAct32814053 details
GRN_HUMANRPC6_HUMANIntAct32814053 details
GRN_HUMANFBLN5_HUMANIntAct32814053 details
GRN_HUMANTI17B_HUMANIntAct32814053 details
GRN_HUMANEED_HUMANBioGRID, IntAct24457600 32814053 details
GRN_HUMANSOX14_HUMANIntAct32814053 details
GRN_HUMANRN138_HUMANIntAct32814053 details
GRN_HUMANPAR11_HUMANIntAct32814053 details
GRN_HUMANZN444_HUMANIntAct32814053 details
GRN_HUMANZN572_HUMANIntAct32814053 details
GRN_HUMANTCP1L_HUMANIntAct32814053 details
GRN_HUMANMSRB3_HUMANIntAct32814053 details
GRN_HUMANSPRE2_HUMANIntAct32814053 details
GRN_HUMANLCE2A_HUMANIntAct32814053 details
GRN_HUMANECM1_HUMANBioGRID, IntAct32296183 details
GRN_HUMANLCE2B_HUMANBioGRID, IntAct32296183 details
GRN_HUMANSPY2_HUMANBioGRID, IntAct25910212 details
GRN_HUMANDVL3_HUMANIntAct32814053 details
GRN_HUMANCYB5_HUMANIntAct32814053 details
GRN_HUMANBAG6_HUMANIntAct32814053 details
GRN_HUMANMLRS_HUMANIntAct32814053 details
GRN_HUMANZN363_HUMANIntAct32814053 details
GRN_HUMANBMF_HUMANIntAct32814053 details
GRN_HUMANZFHX2_HUMANIntAct32814053 details
GRN_HUMANFA98C_HUMANIntAct32814053 details
GRN_HUMANVSX2_HUMANIntAct32814053 details
GRN_HUMANSIR3_HUMANBioGRID, IntAct19343720 32814053 details
GRN_HUMANCRY1_HUMANBioGRID, IntAct21988832 details
GRN_HUMANTNR1B_HUMANMINT24070898 details
GRN_HUMANLCE2D_HUMANBioGRID, IntAct32296183 details
GRN_HUMANCDK9_HUMANBioGRID, HPRD, IntAct12588988 32814053 details
GRN_HUMANIBP4_HUMANIntAct32814053 details
GRN_HUMANHHEX_HUMANIntAct32814053 details
GRN_HUMANFABP7_HUMANIntAct32814053 details
GRN_HUMANTDG_HUMANIntAct32814053 details
GRN_HUMANATL4_HUMANIntAct32814053 details
GRN_HUMANCCD26_HUMANIntAct32814053 details
GRN_HUMANHXK3_HUMANHPRD11068878 details
GRN_HUMANPGBM_HUMANHPRD, MINT12900424 details
GRN_HUMANATN1_HUMANBioGRID, HPRD, IntAct16713569 details
GRN_HUMANPO4F2_HUMANBioGRID, IntAct32296183 details
GRN_HUMANAAPK2_HUMANIntAct32814053 details
GRN_HUMANPALM_HUMANIntAct32814053 details
GRN_HUMANPUM1_HUMANIntAct32814053 details
GRN_HUMANTR61B_HUMANIntAct32814053 details
GRN_HUMANES8L1_HUMANIntAct32814053 details
GRN_HUMANWWOX_HUMANIntAct32814053 details
GRN_HUMANCG031_HUMANIntAct32814053 details
GRN_HUMANTNR1A_HUMANMINT24070898 details
GRN_HUMANCD017_HUMANBioGRID, IntAct32296183 details
GRN_HUMANLCE3C_HUMANBioGRID, IntAct32296183 details
GRN_HUMANTLE5_HUMANBioGRID, IntAct32296183 details
GRN_HUMANCHD1_HUMANIntAct32814053 details
GRN_HUMANDLGP2_HUMANIntAct32814053 details
GRN_HUMANAPC11_HUMANIntAct32814053 details
GRN_HUMANZN696_HUMANIntAct32814053 details
GRN_HUMANTMUB2_HUMANIntAct32814053 details
GRN_HUMANSLPI_HUMANBioGRID, HPRD12526812 details
GRN_HUMANVASN_HUMANBioGRID, IntAct32296183 details
GRN_HUMANSHOX2_HUMANIntAct32814053 details
GRN_HUMANH31_HUMANIntAct32814053 details
GRN_HUMANCITE2_HUMANIntAct32814053 details
GRN_HUMANMYNN_HUMANIntAct32814053 details
GRN_HUMANCG050_HUMANIntAct32814053 details
GRN_HUMANPTPM1_HUMANBioGRID, IntAct32296183 details
GRN_HUMANISK2_HUMANIntAct32814053 details
GRN_HUMANKCC1G_HUMANIntAct32814053 details
GRN_HUMANSHFL_HUMANIntAct32814053 details
GRN_HUMANPLPR1_HUMANIntAct32814053 details
GRN_HUMANGFOD1_HUMANIntAct32814053 details
GRN_HUMANZN697_HUMANIntAct32814053 details
GRN_HUMANMLP3B_HUMANIntAct32814053 details
GRN_HUMANLASP1_HUMANIntAct32814053 details
GRN_HUMANPRPS2_HUMANIntAct32814053 details
GRN_HUMANMSH5_HUMANIntAct32814053 details
GRN_HUMANZN124_HUMANIntAct32814053 details
GRN_HUMANTTC1_HUMANIntAct32814053 details
GRN_HUMANLPIN1_HUMANIntAct32814053 details
GRN_HUMANKLF3_HUMANIntAct32814053 details
GRN_HUMANHYPM_HUMANIntAct32814053 details
GRN_HUMANELAP1_HUMANIntAct32814053 details
GRN_HUMANZF64B_HUMANIntAct32814053 details
GRN_HUMANZN625_HUMANIntAct32814053 details
GRN_HUMANLCE1B_HUMANIntAct32814053 details
GRN_HUMANS13A1_HUMANBioGRID18407958 details
GRN_HUMANLCE1E_HUMANBioGRID, IntAct32296183 details
GRN_HUMANKR121_HUMANBioGRID, IntAct32296183 details
GRN_HUMANCRY2_HUMANIntAct32814053 details
GRN_HUMANCLC11_HUMANIntAct32814053 details
GRN_HUMANRS15A_HUMANIntAct32814053 details
GRN_HUMANZSC26_HUMANIntAct32814053 details
GRN_HUMANCAN15_HUMANIntAct32814053 details
GRN_HUMANCLIP3_HUMANIntAct32814053 details
GRN_HUMANSYT16_HUMANIntAct32814053 details
GRN_HUMANASCL4_HUMANIntAct32814053 details
GRN_HUMANNECD_HUMANIntAct32814053 details
GRN_HUMANSERC3_HUMANIntAct32814053 details
GRN_HUMANCNPY3_HUMANIntAct32814053 details
GRN_HUMANCSN3_HUMANIntAct32814053 details
GRN_HUMANING4_HUMANIntAct32814053 details
GRN_HUMANT53G5_HUMANIntAct32814053 details
GRN_HUMANATIF1_HUMANIntAct32814053 details
GRN_HUMANTCAL8_HUMANIntAct32814053 details
GRN_HUMANSPY4_HUMANIntAct32814053 details
GRN_HUMANTTC23_HUMANIntAct32814053 details
GRN_HUMANRUAS1_HUMANIntAct32814053 details
GRN_HUMANSPRE1_HUMANIntAct32814053 details
GRN_HUMANNACAD_HUMANIntAct32814053 details
GRN_HUMANIF2P_HUMANIntAct32814053 details
GRN_HUMANTBPL1_HUMANIntAct32814053 details
GRN_HUMANNDUF4_HUMANIntAct32814053 details
GRN_HUMANSPSB3_HUMANIntAct32814053 details
GRN_HUMANFAKD1_HUMANIntAct32814053 details
GRN_HUMANRHPN1_HUMANIntAct32814053 details
GRN_HUMANZN791_HUMANIntAct32814053 details
GRN_HUMANTMM61_HUMANIntAct32814053 details
GRN_HUMANCYTA_HUMANIntAct32814053 details
GRN_HUMANHXC4_HUMANIntAct32814053 details
GRN_HUMANPSB10_HUMANIntAct32814053 details
GRN_HUMANTLE1_HUMANIntAct32814053 details
GRN_HUMANCHIP_HUMANIntAct32814053 details
GRN_HUMANDPYL4_HUMANIntAct32814053 details
GRN_HUMANTUT7_HUMANIntAct32814053 details
GRN_HUMANVP37A_HUMANIntAct32814053 details
GRN_HUMANSAP_HUMANUniProt26370502 details
GRN_HUMANYAF2_HUMANIntAct32814053 details
GRN_HUMANRNF14_HUMANIntAct32814053 details
GRN_HUMANZNF57_HUMANIntAct32814053 details
GRN_HUMANZN488_HUMANIntAct32814053 details
GRN_HUMANAMPQ_HUMANIntAct32814053 details
GRN_HUMANCATD_HUMANUniProt28493053 details
GRN_HUMANTNAP3_HUMANBioGRID31585000 details
GRN_HUMANSHAN3_HUMANMINT21653829 details
GRN_HUMANDREB_HUMANIntAct25839164 details
GRN_HUMANELNE_HUMANHPRD12526812 details
GRN_HUMANMBD1_HUMANMINT21653829 details
GRN_HUMANNEMO_HUMANBioGRID31585000 details