Entity Details

Primary name CASP1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP29466
EntryNameCASP1_HUMAN
FullNameCaspase-1
TaxID9606
Evidenceevidence at protein level
Length404
SequenceStatuscomplete
DateCreated1993-04-01
DateModified2021-06-02

Ontological Relatives

GenesCASP1

GO terms

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GOName
GO:0001666 response to hypoxia
GO:0004175 endopeptidase activity
GO:0004197 cysteine-type endopeptidase activity
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0010506 regulation of autophagy
GO:0016540 protein autoprocessing
GO:0019221 cytokine-mediated signaling pathway
GO:0019900 kinase binding
GO:0032730 positive regulation of interleukin-1 alpha production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032991 protein-containing complex
GO:0033198 response to ATP
GO:0035590 purinergic nucleotide receptor signaling pathway
GO:0042802 identical protein binding
GO:0042981 regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0050700 CARD domain binding
GO:0050727 regulation of inflammatory response
GO:0051882 mitochondrial depolarization
GO:0060081 membrane hyperpolarization
GO:0070269 pyroptosis
GO:0071222 cellular response to lipopolysaccharide
GO:0071260 cellular response to mechanical stimulus
GO:0071310 cellular response to organic substance
GO:0071345 cellular response to cytokine stimulus
GO:0071346 cellular response to interferon-gamma
GO:0072557 IPAF inflammasome complex
GO:0072558 NLRP1 inflammasome complex
GO:0072559 NLRP3 inflammasome complex
GO:0097169 AIM2 inflammasome complex
GO:0097179 protease inhibitor complex
GO:0097194 execution phase of apoptosis
GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0097300 programmed necrotic cell death
GO:0140447 cytokine precursor processing
GO:0140448 signaling receptor ligand precursor processing
GO:1901998 toxin transport
GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR001309 Peptidase C14, p20 domainDomainDomain
IPR001315 CARD domainDomainDomain
IPR002138 Peptidase C14, caspase non-catalytic subunit p10DomainDomain
IPR002398 Peptidase C14 familyFamilyFamily
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR015917 Peptidase C14A, caspase catalytic domainDomainDomain
IPR016129 Peptidase family C14A, His active siteSiteActive site
IPR029030 Caspase-like domain superfamilyFamilyHomologous superfamily
IPR033139 Peptidase family C14A, cysteine active siteSiteActive site

Diseases

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Drugs

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DrugNameSourceType
DB00945 Acetylsalicylic acidDrugbanksmall molecule
DB01017 MinocyclineDrugbanksmall molecule
DB04875 PralnacasanDrugbanksmall molecule
DB05301 LAX-101Drugbanksmall molecule
DB05408 EmricasanDrugbanksmall molecule
DB05507 VX-765Drugbanksmall molecule
DB07733 1-METHYL-3-TRIFLUOROMETHYL-1H-THIENO[2,3-C]PYRAZOLE-5-CARBOXYLIC ACID (2-MERCAPTO-ETHYL)-AMIDEDrugbanksmall molecule
DB07744 Z-Val-Ala-Asp fluoromethyl ketoneDrugbanksmall molecule
DB07916 3-{6-[(8-HYDROXY-QUINOLINE-2-CARBONYL)-AMINO]-2-THIOPHEN-2-YL-HEXANOYLAMINO}-4-OXO-BUTYRI ACIDDrugbanksmall molecule

Interactions

73 interactions

InteractorPartnerSourcesPublicationsLink
CASP1_HUMANASC_HUMANBioGRID, HPRD, IntAct11967258 12019269 12191486 24630722 25605870 26121674 32435622 details
CASP1_HUMANCASP1_HUMANBioGRID, DIP, HPRD, IntAct11432859 12459189 24630722 27043298 7721861 9190289 details
CASP1_HUMANVAC14_HUMANBioGRID, IntAct25416956 29892012 32296183 details
CASP1_HUMANA16L1_HUMANIntAct24553140 details
CASP1_HUMANTIRAP_HUMANBioGRID, DIP17360653 20048342 details
CASP1_HUMANIL33_HUMANBioGRID, DIP16286016 19439663 details
CASP1_HUMANIL1B_HUMANBioGRID, DIP, HPRD1919001 19439663 28147281 32122970 7642516 7797510 details
CASP1_HUMANCAR17_HUMANDIP, HPRD15383541 27043298 details
CASP1_HUMANCAR18_HUMANDIP27043298 details
CASP1_HUMANBLMH_HUMANIntAct32814053 details
CASP1_HUMANTM2D1_HUMANIntAct32814053 details
CASP1_HUMANVPS29_HUMANIntAct32814053 details
CASP1_HUMANJIP2_HUMANIntAct32814053 details
CASP1_HUMANTOM1_HUMANIntAct32814053 details
CASP1_HUMANPLPP1_HUMANIntAct32814053 details
CASP1_HUMANSMAD3_HUMANIntAct32814053 details
CASP1_HUMANGFAP_HUMANIntAct32814053 details
CASP1_HUMANPRKN_HUMANHPRD, IntAct12692130 32814053 details
CASP1_HUMANP85A_HUMANIntAct32814053 details
CASP1_HUMANPSN2_HUMANHPRD, IntAct10069390 32814053 9219695 9990034 details
CASP1_HUMANWFS1_HUMANIntAct32814053 details
CASP1_HUMANA4_HUMANIntAct32814053 details
CASP1_HUMANHD_HUMANHPRD, IntAct32814053 9535906 details
CASP1_HUMANATX3_HUMANHPRD, IntAct32814053 9535906 details
CASP1_HUMANBAP31_HUMANBioGRID, HPRD9334338 details
CASP1_HUMANIL37_HUMANBioGRID12096920 details
CASP1_HUMANIL18_HUMANBioGRID, HPRD12096920 9334240 details
CASP1_HUMANCASPA_HUMANBioGRID8962078 details
CASP1_HUMANCASP8_HUMANBioGRID8962078 details
CASP1_HUMANEGFR_HUMANBioGRID, HPRD11226410 details
CASP1_HUMANPARP1_HUMANBioGRID, HPRD7642516 details
CASP1_HUMANPA24B_HUMANBioGRID9875225 details
CASP1_HUMANSPB9_HUMANBioGRID10477277 details
CASP1_HUMANNF2L2_HUMANBioGRID, HPRD10510468 28247911 details
CASP1_HUMANTAU_HUMANBioGRID, HPRD12888622 details
CASP1_HUMANRNF31_HUMANBioGRID32122970 details
CASP1_HUMANHUWE1_HUMANBioGRID33099407 details
CASP1_HUMANRIPK2_HUMANBioGRID, HPRD, MINT9705938 details
CASP1_HUMANNLRP1_HUMANDIP, HPRD, IntAct17418785 18511561 details
CASP1_HUMANNLRC4_HUMANBioGRID, HPRD, IntAct, UniProt11374873 11390368 11472070 15107016 17418785 details
CASP1_HUMANIL1A_HUMANHPRD, IntAct18329368 details
CASP1_HUMANFGF2_HUMANHPRD, IntAct18329368 details
CASP1_HUMANMEFV_HUMANDIP16785446 details
CASP1_HUMANNOD2_HUMANBioGRID, DIP15107016 18511561 details
CASP1_HUMANXK_HUMANBioGRID15107016 details
CASP1_HUMANNOD1_HUMANBioGRID, HPRD10329646 12459189 details
CASP1_HUMANCASPE_HUMANBioGRID, HPRD9792675 details
CASP1_HUMANCEBPB_HUMANBioGRID11684016 details
CASP1_HUMANBIRC3_HUMANBioGRID22195745 details
CASP1_HUMANTRAF2_HUMANBioGRID22195745 details
CASP1_HUMANB2CL1_HUMANBioGRID, HPRD9027312 9435230 details
CASP1_HUMANCAR16_HUMANBioGRID, HPRD11432859 11536016 details
CASP1_HUMANIF16_HUMANBioGRID26121674 details
CASP1_HUMANBRCA1_HUMANBioGRID26121674 details
CASP1_HUMANRBX1_HUMANBioGRID28247911 details
CASP1_HUMANKEAP1_HUMANBioGRID28247911 details
CASP1_HUMANCUL3_HUMANBioGRID28247911 details
CASP1_HUMANIFT57_HUMANBioGRID19934260 details
CASP1_HUMANHIP1_HUMANBioGRID19934260 details
CASP1_HUMANSHRPN_HUMANBioGRID32122970 details
CASP1_HUMANHOIL1_HUMANBioGRID32122970 details
CASP1_HUMANAP2A_HUMANHPRD11438643 details
CASP1_HUMANICAL_HUMANHPRD9705209 details
CASP1_HUMANANDR_HUMANHPRD9535906 details
CASP1_HUMANATN1_HUMANHPRD9535906 details
CASP1_HUMANCD11B_HUMANHPRD9632733 details
CASP1_HUMANPSN1_HUMANHPRD10069390 details
CASP1_HUMANLMNA_HUMANHPRD11953316 8978814 details
CASP1_HUMANBID_HUMANHPRD11085743 9727491 details
CASP1_HUMANNEDD4_HUMANHPRD9593687 details
CASP1_HUMANPAK1_HUMANHPRD15561713 details
CASP1_HUMANCARD8_HUMANHPRD11821383 details
CASP1_HUMANPA24A_HUMANHPRD9875225 details