Entity Details

Primary name CD40L_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP29965
EntryNameCD40L_HUMAN
FullNameCD40 ligand
TaxID9606
Evidenceevidence at protein level
Length261
SequenceStatuscomplete
DateCreated1993-04-01
DateModified2021-06-02

Ontological Relatives

GenesCD40LG

GO terms

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GOName
GO:0002637 regulation of immunoglobulin production
GO:0005125 cytokine activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005174 CD40 receptor binding
GO:0005178 integrin binding
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006954 inflammatory response
GO:0007159 leukocyte cell-cell adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0007257 obsolete activation of JUN kinase activity
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0023035 CD40 signaling pathway
GO:0030168 platelet activation
GO:0030183 B cell differentiation
GO:0031295 T cell costimulation
GO:0032733 positive regulation of interleukin-10 production
GO:0032735 positive regulation of interleukin-12 production
GO:0032753 positive regulation of interleukin-4 production
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0042100 B cell proliferation
GO:0042102 positive regulation of T cell proliferation
GO:0043066 negative regulation of apoptotic process
GO:0045190 isotype switching
GO:0050776 regulation of immune response
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:2000353 positive regulation of endothelial cell apoptotic process

Subcellular Location

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Subcellular Location
Cell membrane
Cell surface
Secreted

Domains

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DomainNameCategoryType
IPR003263 CD40 ligandFamilyFamily
IPR006052 Tumour necrosis factor domainDomainDomain
IPR008983 Tumour necrosis factor-like domain superfamilyFamilyHomologous superfamily
IPR021184 Tumour necrosis factor, conserved siteSiteConserved site

Diseases

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Drugs

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DrugNameSourceType
DB06475 RuplizumabDrugbankbiotech