Entity Details

Primary name PRDX5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP30044
EntryNamePRDX5_HUMAN
FullNamePeroxiredoxin-5, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length214
SequenceStatuscomplete
DateCreated1993-04-01
DateModified2021-06-02

Ontological Relatives

GenesPRDX5

GO terms

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GOName
GO:0001016 RNA polymerase III transcription regulatory region sequence-specific DNA binding
GO:0004601 peroxidase activity
GO:0005102 signaling receptor binding
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005777 peroxisome
GO:0005782 peroxisomal matrix
GO:0005829 cytosol
GO:0006954 inflammatory response
GO:0006979 response to oxidative stress
GO:0008379 thioredoxin peroxidase activity
GO:0016209 antioxidant activity
GO:0016480 negative regulation of transcription by RNA polymerase III
GO:0031410 cytoplasmic vesicle
GO:0032967 positive regulation of collagen biosynthetic process
GO:0034599 cellular response to oxidative stress
GO:0034614 cellular response to reactive oxygen species
GO:0042744 hydrogen peroxide catabolic process
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043231 intracellular membrane-bounded organelle
GO:0045454 cell redox homeostasis
GO:0048471 perinuclear region of cytoplasm
GO:0051354 negative regulation of oxidoreductase activity
GO:0051920 peroxiredoxin activity
GO:0060785 regulation of apoptosis involved in tissue homeostasis
GO:0070062 extracellular exosome
GO:0070995 NADPH oxidation
GO:0072541 peroxynitrite reductase activity
GO:2001057 reactive nitrogen species metabolic process

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion
Peroxisome matrix

Domains

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DomainNameCategoryType
IPR013740 RedoxinDomainDomain
IPR013766 Thioredoxin domainDomainDomain
IPR036249 Thioredoxin-like superfamilyFamilyHomologous superfamily
IPR037944 Peroxiredoxin-5-likeFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB00995 AuranofinDrugbanksmall molecule
DB03608 DiminazeneDrugbanksmall molecule
DB09221 PolaprezincDrugbanksmall molecule