Entity Details

Primary name MC4R_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP32245
EntryNameMC4R_HUMAN
FullNameMelanocortin receptor 4
TaxID9606
Evidenceevidence at protein level
Length332
SequenceStatuscomplete
DateCreated1993-10-01
DateModified2021-06-02

Ontological Relatives

GenesMC4R

GO terms

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GOName
GO:0002024 diet induced thermogenesis
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0004930 G protein-coupled receptor activity
GO:0004977 melanocortin receptor activity
GO:0004980 melanocyte-stimulating hormone receptor activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0006112 energy reserve metabolic process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007631 feeding behavior
GO:0016021 integral component of membrane
GO:0017046 peptide hormone binding
GO:0019222 regulation of metabolic process
GO:0031625 ubiquitin protein ligase binding
GO:0042923 neuropeptide binding
GO:0045780 positive regulation of bone resorption
GO:2000252 negative regulation of feeding behavior
GO:2000821 regulation of grooming behavior

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000155 Melanocortin 4 receptorFamilyFamily
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR001671 Melanocortin/ACTH receptorFamilyFamily
IPR001908 Melanocortin receptorFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB11653 BremelanotideDrugbanksmall molecule
DB11700 SetmelanotideDrugbanksmall molecule