Entity Details

Primary name GLYC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP34896
EntryNameGLYC_HUMAN
FullNameSerine hydroxymethyltransferase, cytosolic
TaxID9606
Evidenceevidence at protein level
Length483
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesSHMT1

GO terms

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GOName
GO:0000900 translation repressor activity, mRNA regulatory element binding
GO:0004372 glycine hydroxymethyltransferase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006544 glycine metabolic process
GO:0006563 L-serine metabolic process
GO:0006565 L-serine catabolic process
GO:0006730 one-carbon metabolic process
GO:0008270 zinc ion binding
GO:0008732 L-allo-threonine aldolase activity
GO:0009113 purine nucleobase biosynthetic process
GO:0017148 negative regulation of translation
GO:0019264 glycine biosynthetic process from serine
GO:0030170 pyridoxal phosphate binding
GO:0035999 tetrahydrofolate interconversion
GO:0036094 small molecule binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0045329 carnitine biosynthetic process
GO:0046653 tetrahydrofolate metabolic process
GO:0046655 folic acid metabolic process
GO:0048027 mRNA 5'-UTR binding
GO:0050897 cobalt ion binding
GO:0051289 protein homotetramerization
GO:0070062 extracellular exosome
GO:0070905 serine binding
GO:1904482 cellular response to tetrahydrofolate
GO:1990830 cellular response to leukemia inhibitory factor

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR001085 Serine hydroxymethyltransferaseFamilyFamily
IPR015421 Pyridoxal phosphate-dependent transferase, major domainFamilyHomologous superfamily
IPR015422 Pyridoxal phosphate-dependent transferase, small domainFamilyHomologous superfamily
IPR015424 Pyridoxal phosphate-dependent transferaseFamilyHomologous superfamily
IPR019798 Serine hydroxymethyltransferase, pyridoxal phosphate binding siteSiteBinding site
IPR039429 Serine hydroxymethyltransferase-like domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00114 Pyridoxal phosphateDrugbanksmall molecule
DB00116 Tetrahydrofolic acidDrugbanksmall molecule
DB00145 GlycineDrugbanksmall molecule
DB01055 MimosineDrugbanksmall molecule
DB02067 Triglu-5-formyl-tetrahydrofolateDrugbanksmall molecule
DB02800 5-hydroxymethyl-5,6-dihydrofolic acidDrugbanksmall molecule
DB02824 N-Pyridoxyl-Glycine-5-MonophosphateDrugbanksmall molecule