Entity Details

Primary name HYES_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP34913
EntryNameHYES_HUMAN
FullNameBifunctional epoxide hydrolase 2
TaxID9606
Evidenceevidence at protein level
Length555
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesEPHX2

GO terms

Show/Hide Table
GOName
GO:0005782 peroxisomal matrix
GO:0016791 phosphatase activity
GO:0042632 cholesterol homeostasis
GO:0016311 dephosphorylation
GO:0019373 epoxygenase P450 pathway
GO:0097176 epoxide metabolic process
GO:0005829 cytosol
GO:0009636 response to toxic substance
GO:0042577 lipid phosphatase activity
GO:0042759 long-chain fatty acid biosynthetic process
GO:0004301 epoxide hydrolase activity
GO:0016787 hydrolase activity
GO:0052642 lysophosphatidic acid phosphatase activity
GO:0070062 extracellular exosome
GO:0042803 protein homodimerization activity
GO:0046839 phospholipid dephosphorylation
GO:0005777 peroxisome
GO:0010628 positive regulation of gene expression
GO:0008104 protein localization
GO:0046272 stilbene catabolic process
GO:0015643 toxic substance binding
GO:0033885 10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity
GO:0000287 magnesium ion binding
GO:0090181 regulation of cholesterol metabolic process

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm
Peroxisome

Domains

Show/Hide Table
DomainNameCategoryType
IPR000073 Alpha/beta hydrolase fold-1DomainDomain
IPR000639 Epoxide hydrolase-likeFamilyFamily
IPR006439 HAD hydrolase, subfamily IAFamilyFamily
IPR011945 Predicted HAD-superfamily phosphatase, subfamily IA/Epoxide hydrolase, N-terminalDomainDomain
IPR023198 Phosphoglycolate phosphatase-like, domain 2FamilyHomologous superfamily
IPR023214 HAD superfamilyFamilyHomologous superfamily
IPR029058 Alpha/Beta hydrolase foldFamilyHomologous superfamily
IPR036412 HAD-like superfamilyFamilyHomologous superfamily
IPR041492 Haloacid dehalogenase-like hydrolaseFamilyFamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB02029 N-Cyclohexyl-N'-(4-Iodophenyl)UreaDrugbanksmall molecule
DB03677 N-Cyclohexyl-N'-DecylureaDrugbanksmall molecule
DB04213 N-Cyclohexyl-N'-(Propyl)Phenyl UreaDrugbanksmall molecule
DB06345 AR-9281Drugbanksmall molecule
DB08256 N-[(CYCLOHEXYLAMINO)CARBONYL]GLYCINEDrugbanksmall molecule
DB08257 4-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}BUTANOIC ACIDDrugbanksmall molecule
DB08258 6-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}HEXANOIC ACIDDrugbanksmall molecule
DB08259 7-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}HEPTANOIC ACIDDrugbanksmall molecule
DB12610 EbselenDrugbanksmall molecule

Interactions

5 interactions