Entity Details

Primary name TIE1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP35590
EntryNameTIE1_HUMAN
FullNameTyrosine-protein kinase receptor Tie-1
TaxID9606
Evidenceevidence at protein level
Length1138
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesTIE1

GO terms

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GOName
GO:0001525 angiogenesis
GO:0001570 vasculogenesis
GO:0001701 in utero embryonic development
GO:0001936 regulation of endothelial cell proliferation
GO:0003180 aortic valve morphogenesis
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005887 integral component of plasma membrane
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0007498 mesoderm development
GO:0016525 negative regulation of angiogenesis
GO:0030336 negative regulation of cell migration
GO:0032526 response to retinoic acid
GO:0033674 positive regulation of kinase activity
GO:0043235 receptor complex
GO:0045026 plasma membrane fusion
GO:0045766 positive regulation of angiogenesis
GO:0048771 tissue remodeling
GO:0060836 lymphatic endothelial cell differentiation
GO:0060854 branching involved in lymph vessel morphogenesis
GO:1901201 regulation of extracellular matrix assembly

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000742 EGF-like domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR003961 Fibronectin type IIIDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013151 ImmunoglobulinDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule