Entity Details

Primary name PRS7_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP35998
EntryNamePRS7_HUMAN
FullName26S proteasome regulatory subunit 7
TaxID9606
Evidenceevidence at protein level
Length433
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesPSMC2

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000209 protein polyubiquitination
GO:0000502 proteasome complex
GO:0000932 P-body
GO:0001649 osteoblast differentiation
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006521 regulation of cellular amino acid metabolic process
GO:0008540 proteasome regulatory particle, base subcomplex
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle
GO:0016020 membrane
GO:0016579 protein deubiquitination
GO:0016887 ATP hydrolysis activity
GO:0017025 TBP-class protein binding
GO:0022624 proteasome accessory complex
GO:0031145 anaphase-promoting complex-dependent catabolic process
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0034774 secretory granule lumen
GO:0036388 pre-replicative complex assembly
GO:0036402 proteasome-activating activity
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0038061 NIK/NF-kappaB signaling
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043197 dendritic spine
GO:0043312 neutrophil degranulation
GO:0043488 regulation of mRNA stability
GO:0043687 post-translational protein modification
GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly
GO:0050852 T cell receptor signaling pathway
GO:0055085 transmembrane transport
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070498 interleukin-1-mediated signaling pathway
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1901990 regulation of mitotic cell cycle phase transition
GO:1902036 regulation of hematopoietic stem cell differentiation
GO:1904813 ficolin-1-rich granule lumen

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR003593 AAA+ ATPase domainDomainDomain
IPR003959 ATPase, AAA-type, coreDomainDomain
IPR003960 ATPase, AAA-type, conserved siteSiteConserved site
IPR005937 26S proteasome regulatory subunit P45-likeFamilyFamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR035245 26S Proteasome regulatory subunit 7FamilyFamily
IPR041569 AAA ATPase, AAA+ lid domainDomainDomain

Diseases

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Interactions

78 interactions

InteractorPartnerSourcesPublicationsLink
PRS7_HUMANSKIL_HUMANBioGRID, HPRD, MINT15231748 details
PRS7_HUMANMYZAP_HUMANBioGRID, IntAct16169070 details
PRS7_HUMANGRL1A_HUMANBioGRID, HPRD, IntAct16169070 details
PRS7_HUMANPSMD5_HUMANBioGRID, HPRD, IntAct, MINT10625621 16189514 19412159 19490896 21516116 22921402 22939629 25416956 26344197 27107012 28514442 28539385 30217970 31515488 32296183 details
PRS7_HUMANRD23B_HUMANBioGRID, DIP, MINT16712842 22939629 26344197 28539385 9490418 details
PRS7_HUMANPRS8_HUMANBioGRID, IntAct, MINT16763564 19490896 21628461 22275368 22901813 22939629 26344197 28292943 28514442 9464850 details
PRS7_HUMANPRS6B_HUMANBioGRID, HPRD, IntAct11361004 17353931 21628461 22275368 22863883 22901813 22939629 26344197 28292943 28514442 details
PRS7_HUMANPSMD4_HUMANBioGRID, DIP, MINT16990800 21628461 22863883 22921402 22939629 24429290 26344197 28539385 30479383 details
PRS7_HUMANPRS10_HUMANBioGRID, DIP, IntAct19490896 22863883 22901813 22939629 26344197 27342858 28292943 29636472 9464850 details
PRS7_HUMANPRS4_HUMANBioGRID, HPRD, IntAct10625621 11361004 19490896 21628461 22863883 22901813 22921402 22939629 26186194 26344197 26496610 28292943 28514442 30217970 details
PRS7_HUMANPSMD2_HUMANBioGRID, HPRD, IntAct10625621 20810900 22275368 22863883 22901813 22921402 22939629 26344197 28292943 28539385 32296183 details
PRS7_HUMANPRS6A_HUMANBioGRID, IntAct21628461 22275368 22863883 22901813 22939629 26344197 28292943 28514442 9464850 details
PRS7_HUMANCDN1A_HUMANBioGRID, IntAct27107012 details
PRS7_HUMANKLF11_HUMANIntAct32814053 details
PRS7_HUMANNUP58_HUMANIntAct32814053 details
PRS7_HUMANOPTN_HUMANIntAct32814053 details
PRS7_HUMANGL1AD_HUMANBioGRID, HPRD16169070 details
PRS7_HUMANNDC80_HUMANBioGRID, HPRD9295362 details
PRS7_HUMANPSMD1_HUMANBioGRID19589775 21767633 22863883 22939629 26344197 28292943 details
PRS7_HUMANTRIM5_HUMANBioGRID22078707 details
PRS7_HUMANPRS7_HUMANBioGRID15782218 22275368 28292943 details
PRS7_HUMANPSA7_HUMANBioGRID22939629 26344197 28292943 details
PRS7_HUMANPRKN_HUMANBioGRID23503661 25666615 details
PRS7_HUMANUBC_HUMANBioGRID24743594 28190767 details
PRS7_HUMANUBE2C_HUMANBioGRID20007692 details
PRS7_HUMANUBQL2_HUMANBioGRID25666615 30442662 details
PRS7_HUMANUBCP1_HUMANBioGRID27880917 28539385 details
PRS7_HUMANCNOT7_HUMANBioGRID30217970 details
PRS7_HUMANCEP55_HUMANBioGRID30217970 details
PRS7_HUMANOGT1_HUMANBioGRID32994395 details
PRS7_HUMANCHIP_HUMANBioGRID32723828 details
PRS7_HUMANRD23A_HUMANBioGRID, MINT16712842 19013454 23260144 26344197 details
PRS7_HUMANPSMD6_HUMANBioGRID, IntAct17353931 22275368 22863883 22939629 26344197 details
PRS7_HUMANPSD10_HUMANBioGRID, IntAct17353931 19490896 22939629 26186194 26344197 28539385 details
PRS7_HUMAN3MG_HUMANIntAct17353931 details
PRS7_HUMANSOMA_HUMANIntAct17353931 details
PRS7_HUMANPAAF1_HUMANBioGRID, IntAct15831487 17353931 28539385 details
PRS7_HUMANIKKE_HUMANIntAct17353931 details
PRS7_HUMANPSDE_HUMANBioGRID, IntAct17323924 19615732 22863883 22939629 26344197 26496610 27428775 28539385 28821611 30745168 32723828 details
PRS7_HUMANPSB5_HUMANBioGRID, IntAct21628461 22901813 22939629 26344197 details
PRS7_HUMANUN45B_HUMANIntAct25036637 details
PRS7_HUMANPTG3L_HUMANIntAct25036637 details
PRS7_HUMANAASD1_HUMANIntAct25036637 details
PRS7_HUMANSEM1_HUMANBioGRID, MINT15610744 16239144 24811749 details
PRS7_HUMANTAU_HUMANBioGRID, UniProt15953362 26269332 details
PRS7_HUMANTNIK_HUMANIntAct31413325 details
PRS7_HUMANTBP_HUMANBioGRID, HPRD11118327 details
PRS7_HUMANTF2B_HUMANBioGRID, HPRD11118327 details
PRS7_HUMANTF2H1_HUMANBioGRID, HPRD11118327 details
PRS7_HUMANT2FA_HUMANBioGRID, HPRD11118325 11118327 details
PRS7_HUMANATX7_HUMANBioGRID11734547 details
PRS7_HUMANPMS2_HUMANBioGRID17148452 details
PRS7_HUMANPSA1_HUMANBioGRID21733848 22939629 26344197 details
PRS7_HUMANC2TA_HUMANBioGRID20351748 details
PRS7_HUMANSEML_HUMANBioGRID15610744 16239144 24811749 details
PRS7_HUMANPSMD8_HUMANBioGRID21628461 21767633 22275368 22863883 22939629 26344197 details
PRS7_HUMANHSP74_HUMANBioGRID21767633 details
PRS7_HUMANM3K5_HUMANBioGRID20843792 details
PRS7_HUMANFKBP8_HUMANBioGRID17573772 details
PRS7_HUMANSQSTM_HUMANBioGRID15340068 31037147 details
PRS7_HUMANPSA2_HUMANBioGRID19193609 22939629 26344197 details
PRS7_HUMANPSB2_HUMANBioGRID22939629 26344197 32723828 details
PRS7_HUMANUBQL1_HUMANBioGRID22939629 26476452 details
PRS7_HUMANPCD10_HUMANBioGRID23260144 details
PRS7_HUMANSPRTN_HUMANBioGRID23254330 details
PRS7_HUMANABCE1_HUMANBioGRID25659154 details
PRS7_HUMANPSMD9_HUMANBioGRID26344197 28539385 details
PRS7_HUMANTRI18_HUMANBioGRID26748699 details
PRS7_HUMANTRIM1_HUMANBioGRID26748699 details
PRS7_HUMANHERC3_HUMANBioGRID26476452 details
PRS7_HUMANTF65_HUMANBioGRID26476452 details
PRS7_HUMANCEP85_HUMANBioGRID26472760 details
PRS7_HUMANATOH1_HUMANBioGRID27542412 details
PRS7_HUMANDERL1_HUMANBioGRID28137758 details
PRS7_HUMANUBE3A_HUMANBioGRID22645313 29426014 30257870 details
PRS7_HUMANARAF_HUMANBioGRID29777862 details
PRS7_HUMANGSK3B_HUMANBioGRID31037147 details
PRS7_HUMANSUMO4_HUMANHPRD16236267 details