Entity Details

Primary name MP2K2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP36507
EntryNameMP2K2_HUMAN
FullNameDual specificity mitogen-activated protein kinase kinase 2
TaxID9606
Evidenceevidence at protein level
Length400
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesMAP2K2

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000186 obsolete activation of MAPKK activity
GO:0000187 obsolete activation of MAPK activity
GO:0004708 MAP kinase kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005078 MAP-kinase scaffold activity
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005778 peroxisomal membrane
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005874 microtubule
GO:0005911 cell-cell junction
GO:0005925 focal adhesion
GO:0009898 cytoplasmic side of plasma membrane
GO:0010629 negative regulation of gene expression
GO:0030165 PDZ domain binding
GO:0032872 regulation of stress-activated MAPK cascade
GO:0036289 peptidyl-serine autophosphorylation
GO:0043539 protein serine/threonine kinase activator activity
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046872 metal ion binding
GO:0048471 perinuclear region of cytoplasm
GO:0070371 ERK1 and ERK2 cascade
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0090170 regulation of Golgi inheritance
GO:0097110 scaffold protein binding
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA
GO:2000641 regulation of early endosome to late endosome transport

Subcellular Location

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Subcellular Location
Cytoplasm
Membrane

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

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Drugs

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DrugNameSourceType
DB06616 BosutinibDrugbanksmall molecule
DB08911 TrametinibDrugbanksmall molecule
DB11689 SelumetinibDrugbanksmall molecule
DB11967 BinimetinibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

30 interactions

InteractorPartnerSourcesPublicationsLink
MP2K2_HUMANARAF_HUMANBioGRID, HPRD, IntAct11909642 21988832 24746704 25852190 31980649 32296183 details
MP2K2_HUMANRAF1_HUMANBioGRID, HPRD, IntAct11909642 16364241 19058874 21988832 24746704 31980649 8157000 8393135 9671314 9808624 details
MP2K2_HUMANMP2K2_HUMANBioGRID, HPRD, IntAct11909642 17192257 31980649 8226933 details
MP2K2_HUMANKSR1_HUMANBioGRID, IntAct11909642 27086506 31980649 details
MP2K2_HUMANCSN5_HUMANBioGRID, IntAct18624398 20936779 details
MP2K2_HUMANZN207_HUMANBioGRID, IntAct21988832 details
MP2K2_HUMANRIPR2_HUMANBioGRID, IntAct21988832 details
MP2K2_HUMANDLG1_HUMANMINT21615688 details
MP2K2_HUMANCCDB1_HUMANBioGRID, IntAct25416956 details
MP2K2_HUMANHNRPK_HUMANBioGRID, IntAct32296183 details
MP2K2_HUMANMOS_HUMANBioGRID, IntAct32296183 details
MP2K2_HUMANA4_HUMANIntAct32814053 details
MP2K2_HUMANMK01_HUMANBioGRID, HPRD, IntAct11134045 11823456 12788955 21675959 23519423 details
MP2K2_HUMANMK03_HUMANBioGRID, HPRD7687743 8226933 8626767 9006895 details
MP2K2_HUMANMK08_HUMANBioGRID16533805 details
MP2K2_HUMANDNLI4_HUMANBioGRID22990118 details
MP2K2_HUMANCNKR1_HUMANHPRD9427625 details
MP2K2_HUMANRGS12_HUMANHPRD17380122 details
MP2K2_HUMANCRCM_HUMANIntAct17353931 details
MP2K2_HUMANBRAF_HUMANBioGRID, HPRD, IntAct17979178 24746704 25600339 27034005 28514442 31980649 8668348 details
MP2K2_HUMAN1433B_HUMANBioGRID, IntAct10409742 24255178 31980649 details
MP2K2_HUMANMP2K1_HUMANBioGRID, IntAct10409742 28514442 details
MP2K2_HUMANWDR83_HUMANBioGRID15118098 details
MP2K2_HUMANIQGA1_HUMANBioGRID24639526 details
MP2K2_HUMANNF2L2_HUMANBioGRID24704364 details
MP2K2_HUMANDUS3_HUMANHPRD10224087 details
MP2K2_HUMANCASP9_HUMANHPRD12792650 details
MP2K2_HUMANNMDE4_HUMANHPRD10862698 details
MP2K2_HUMANLTOR3_HUMANHPRD9733512 details
MP2K2_HUMANNMDZ1_HUMANHPRD10862698 details