Entity Details

Primary name ACHA7_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP36544
EntryNameACHA7_HUMAN
FullNameNeuronal acetylcholine receptor subunit alpha-7
TaxID9606
Evidenceevidence at protein level
Length502
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0001540 amyloid-beta binding
GO:0001666 response to hypoxia
GO:0001934 positive regulation of protein phosphorylation
GO:0005216 ion channel activity
GO:0005262 calcium channel activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005892 acetylcholine-gated channel complex
GO:0006811 ion transport
GO:0006816 calcium ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0007165 signal transduction
GO:0007268 chemical synaptic transmission
GO:0007271 synaptic transmission, cholinergic
GO:0007611 learning or memory
GO:0007613 memory
GO:0007614 short-term memory
GO:0008284 positive regulation of cell population proliferation
GO:0015464 acetylcholine receptor activity
GO:0015643 toxic substance binding
GO:0016021 integral component of membrane
GO:0017081 chloride channel regulator activity
GO:0022848 acetylcholine-gated cation-selective channel activity
GO:0030594 neurotransmitter receptor activity
GO:0032720 negative regulation of tumor necrosis factor production
GO:0034220 ion transmembrane transport
GO:0035094 response to nicotine
GO:0042166 acetylcholine binding
GO:0042391 regulation of membrane potential
GO:0042803 protein homodimerization activity
GO:0043005 neuron projection
GO:0044853 plasma membrane raft
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0045766 positive regulation of angiogenesis
GO:0050808 synapse organization
GO:0050877 nervous system process
GO:0050890 cognition
GO:0050893 sensory processing
GO:0051247 positive regulation of protein metabolic process
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0095500 acetylcholine receptor signaling pathway
GO:0097061 dendritic spine organization
GO:0098794 postsynapse
GO:0098815 modulation of excitatory postsynaptic potential
GO:0140059 dendrite arborization
GO:1900273 positive regulation of long-term synaptic potentiation
GO:1901214 regulation of neuron death
GO:1902004 positive regulation of amyloid-beta formation
GO:1902430 negative regulation of amyloid-beta formation
GO:1902991 regulation of amyloid precursor protein catabolic process
GO:1904645 response to amyloid-beta
GO:1905144 response to acetylcholine
GO:1905906 regulation of amyloid fibril formation
GO:1905920 positive regulation of CoA-transferase activity
GO:2000463 positive regulation of excitatory postsynaptic potential

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane

Domains

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DomainNameCategoryType
IPR002394 Nicotinic acetylcholine receptorFamilyFamily
IPR006029 Neurotransmitter-gated ion-channel transmembrane domainDomainDomain
IPR006201 Neurotransmitter-gated ion-channelFamilyFamily
IPR006202 Neurotransmitter-gated ion-channel ligand-binding domainDomainDomain
IPR018000 Neurotransmitter-gated ion-channel, conserved siteSiteConserved site
IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamilyFamilyHomologous superfamily
IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00122 CholineDrugbanksmall molecule
DB00184 NicotineDrugbanksmall molecule
DB00237 ButabarbitalDrugbanksmall molecule
DB00241 ButalbitalDrugbanksmall molecule
DB00306 TalbutalDrugbanksmall molecule
DB00312 PentobarbitalDrugbanksmall molecule
DB00333 MethadoneDrugbanksmall molecule
DB00418 SecobarbitalDrugbanksmall molecule
DB00463 MetharbitalDrugbanksmall molecule
DB00514 DextromethorphanDrugbanksmall molecule
DB00599 ThiopentalDrugbanksmall molecule
DB00657 MecamylamineDrugbanksmall molecule
DB00674 GalantamineDrugbanksmall molecule
DB00794 PrimidoneDrugbanksmall molecule
DB00849 MethylphenobarbitalDrugbanksmall molecule
DB00898 EthanolDrugbanksmall molecule
DB00915 AmantadineDrugbanksmall molecule
DB01174 PhenobarbitalDrugbanksmall molecule
DB01199 TubocurarineDrugbanksmall molecule
DB01273 VareniclineDrugbanksmall molecule
DB01351 AmobarbitalDrugbanksmall molecule
DB01352 AprobarbitalDrugbanksmall molecule
DB01353 ButobarbitalDrugbanksmall molecule
DB01354 HeptabarbitalDrugbanksmall molecule
DB01355 HexobarbitalDrugbanksmall molecule
DB01483 BarbitalDrugbanksmall molecule
DB01496 Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedioneDrugbanksmall molecule
DB03128 AcetylcholineDrugbanksmall molecule
DB05137 LobelineDrugbanksmall molecule
DB05708 GTS-21Drugbanksmall molecule
DB05740 RPI-78MDrugbanksmall molecule
DB07720 EpibatidineDrugbanksmall molecule
DB09028 CytisineDrugbanksmall molecule
DB09061 CannabidiolDrugbanksmall molecule
DB11726 EnceniclineDrugbanksmall molecule
DB14006 Choline salicylateDrugbanksmall molecule
DB14009 Medical CannabisDrugbankbiotech
DB14011 NabiximolsDrugbanksmall molecule