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Entity Details
Primary name
M3K8_HUMAN
Entity type
UniProt
Source
Source Link
Details
Accession
P41279
EntryName
M3K8_HUMAN
FullName
Mitogen-activated protein kinase kinase kinase 8
TaxID
9606
Evidence
evidence at protein level
Length
467
SequenceStatus
complete
DateCreated
1995-02-01
DateModified
2021-06-02
Ontological Relatives
Genes
MAP3K8
GO terms
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GO
Name
GO:0000287
magnesium ion binding
GO:0004674
protein serine/threonine kinase activity
GO:0004709
MAP kinase kinase kinase activity
GO:0005524
ATP binding
GO:0005829
cytosol
GO:0006468
protein phosphorylation
GO:0007049
cell cycle
GO:0031295
T cell costimulation
GO:0051403
stress-activated MAPK cascade
GO:0070498
interleukin-1-mediated signaling pathway
GO:0106310
protein serine kinase activity
GO:0106311
protein threonine kinase activity
Subcellular Location
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Subcellular Location
Cytoplasm
Domains
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Domain
Name
Category
Type
IPR000719
Protein kinase domain
Domain
Domain
IPR008271
Serine/threonine-protein kinase, active site
Site
Active site
IPR011009
Protein kinase-like domain superfamily
Family
Homologous superfamily
IPR017424
Mitogen-activated protein (MAP) kinase kinase kinase 8
Family
Family
Diseases
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Drugs
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Interactions
40 interactions
Interactor
Partner
Sources
Publications
Link
M3K8_HUMAN
TNIP2_HUMAN
BioGRID, HPRD, IntAct
14743216
15169888
25852190
29084252
details
M3K8_HUMAN
NFKB1_HUMAN
BioGRID, HPRD, IntAct, MINT
12832462
14743216
15169888
16291755
21988832
25609649
25852190
29084252
9950430
details
M3K8_HUMAN
TF65_HUMAN
BioGRID, HPRD, IntAct
14743216
25331947
25852190
29084252
9950430
details
M3K8_HUMAN
STIP1_HUMAN
BioGRID, IntAct
21988832
details
M3K8_HUMAN
ACY3_HUMAN
BioGRID, IntAct
21988832
details
M3K8_HUMAN
MP2K1_HUMAN
BioGRID, IntAct
12832462
16291755
8631303
details
M3K8_HUMAN
PIN1_HUMAN
IntAct
24265246
details
M3K8_HUMAN
IKKA_HUMAN
BioGRID, HPRD
10072079
details
M3K8_HUMAN
MP2K4_HUMAN
BioGRID, HPRD
8631303
details
M3K8_HUMAN
AKT1_HUMAN
BioGRID, HPRD
12138205
details
M3K8_HUMAN
HS71L_HUMAN
IntAct
14743216
details
M3K8_HUMAN
BIP_HUMAN
IntAct
14743216
details
M3K8_HUMAN
GRP75_HUMAN
IntAct
14743216
details
M3K8_HUMAN
EPIPL_HUMAN
IntAct
14743216
details
M3K8_HUMAN
M3K8_HUMAN
IntAct
14743216
details
M3K8_HUMAN
EF1A2_HUMAN
IntAct
14743216
details
M3K8_HUMAN
RUVB1_HUMAN
IntAct
14743216
details
M3K8_HUMAN
LG3BP_HUMAN
IntAct
14743216
details
M3K8_HUMAN
CLH1_HUMAN
IntAct
14743216
details
M3K8_HUMAN
HSP7C_HUMAN
IntAct
14743216
details
M3K8_HUMAN
CALM2_HUMAN
IntAct
14743216
details
M3K8_HUMAN
TBB5_HUMAN
IntAct
14743216
details
M3K8_HUMAN
PFKAL_HUMAN
IntAct
14743216
details
M3K8_HUMAN
TBB4A_HUMAN
IntAct
14743216
details
M3K8_HUMAN
ACL6A_HUMAN
IntAct
14743216
details
M3K8_HUMAN
SPTB2_HUMAN
IntAct
14743216
details
M3K8_HUMAN
DESP_HUMAN
IntAct
14743216
details
M3K8_HUMAN
HS90A_HUMAN
BioGRID, IntAct
14743216
22939624
details
M3K8_HUMAN
TBA3C_HUMAN
IntAct
14743216
details
M3K8_HUMAN
TBA3D_HUMAN
IntAct
14743216
details
M3K8_HUMAN
HS90B_HUMAN
IntAct
14743216
22939624
details
M3K8_HUMAN
REL_HUMAN
BioGRID, HPRD, IntAct
14743216
9950430
details
M3K8_HUMAN
KSR2_HUMAN
BioGRID
12975377
details
M3K8_HUMAN
M3K14_HUMAN
BioGRID, HPRD
10072079
11278268
9742107
details
M3K8_HUMAN
TRAF2_HUMAN
BioGRID, HPRD
11932422
15670770
16291755
details
M3K8_HUMAN
TNR5_HUMAN
BioGRID, HPRD
15670770
details
M3K8_HUMAN
TRAF6_HUMAN
BioGRID, HPRD
15670770
details
M3K8_HUMAN
TAB2_HUMAN
BioGRID
15670770
details
M3K8_HUMAN
RIPK1_HUMAN
BioGRID, HPRD
16291755
details
M3K8_HUMAN
BMPR2_HUMAN
HPRD
15188402
details
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