Entity Details

Primary name STAT1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP42224
EntryNameSTAT1_HUMAN
FullNameSignal transducer and activator of transcription 1-alpha/beta
TaxID9606
Evidenceevidence at protein level
Length750
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesSTAT1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001937 negative regulation of endothelial cell proliferation
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002230 positive regulation of defense response to virus by host
GO:0003340 negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0003690 double-stranded DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006355 regulation of transcription, DNA-templated
GO:0006952 defense response
GO:0007221 positive regulation of transcription of Notch receptor target
GO:0007259 receptor signaling pathway via JAK-STAT
GO:0008015 blood circulation
GO:0010742 macrophage derived foam cell differentiation
GO:0016032 viral process
GO:0016525 negative regulation of angiogenesis
GO:0019221 cytokine-mediated signaling pathway
GO:0019899 enzyme binding
GO:0030424 axon
GO:0030425 dendrite
GO:0032727 positive regulation of interferon-alpha production
GO:0032991 protein-containing complex
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0034097 response to cytokine
GO:0035035 histone acetyltransferase binding
GO:0035456 response to interferon-beta
GO:0035458 cellular response to interferon-beta
GO:0038113 interleukin-9-mediated signaling pathway
GO:0038114 interleukin-21-mediated signaling pathway
GO:0042127 regulation of cell population proliferation
GO:0042393 histone binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0042981 regulation of apoptotic process
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043434 response to peptide hormone
GO:0044389 ubiquitin-like protein ligase binding
GO:0045296 cadherin binding
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046725 negative regulation by virus of viral protein levels in host cell
GO:0048471 perinuclear region of cytoplasm
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0051591 response to cAMP
GO:0051607 defense response to virus
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060334 regulation of interferon-gamma-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
GO:0061326 renal tubule development
GO:0070102 interleukin-6-mediated signaling pathway
GO:0070106 interleukin-27-mediated signaling pathway
GO:0070757 interleukin-35-mediated signaling pathway
GO:0071346 cellular response to interferon-gamma
GO:0072136 metanephric mesenchymal cell proliferation involved in metanephros development
GO:0072162 metanephric mesenchymal cell differentiation
GO:0072308 negative regulation of metanephric nephron tubule epithelial cell differentiation
GO:1990841 promoter-specific chromatin binding

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000980 SH2 domainDomainDomain
IPR001217 Transcription factor STATFamilyFamily
IPR008967 p53-like transcription factor, DNA-bindingFamilyHomologous superfamily
IPR012345 STAT transcription factor, DNA-binding, N-terminalFamilyHomologous superfamily
IPR013799 STAT transcription factor, protein interactionDomainDomain
IPR013800 STAT transcription factor, all-alpha domainDomainDomain
IPR013801 STAT transcription factor, DNA-bindingDomainDomain
IPR015988 STAT transcription factor, coiled coilFamilyHomologous superfamily
IPR022752 Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminalDomainDomain
IPR035859 STAT1, SH2 domainDomainDomain
IPR036535 STAT transcription factor, N-terminal domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily
IPR038295 STAT1, C-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

163 interactions

InteractorPartnerSourcesPublicationsLink
STAT1_HUMANRBTN2_HUMANBioGRID, HPRD, IntAct16189514 25416956 details
STAT1_HUMANEIF1A_HUMANBioGRID, HPRD, IntAct16189514 25416956 details
STAT1_HUMANERBB2_HUMANBioGRID, IntAct, MINT16273093 25241761 details
STAT1_HUMANNMI_HUMANBioGRID, HPRD, IntAct9989503 details
STAT1_HUMANSTAT2_HUMANBioGRID, HPIDb, HPRD, IntAct, MINT10446176 10490982 12048190 15825084 17923090 24065129 26966684 28514442 31836668 8605877 8621447 9724754 details
STAT1_HUMANIRF9_HUMANBioGRID, HPRD, IntAct, MINT17923090 24065129 8943351 details
STAT1_HUMANE2F1_HUMANBioGRID, IntAct20195357 details
STAT1_HUMANINGR1_HUMANBioGRID, HPRD, MINT10848598 15494521 15780933 21689637 7514165 8156998 8662591 details
STAT1_HUMANEGFR_HUMANBioGRID, HPRD, IntAct, MINT10358079 10918587 11294897 11839738 12070153 12637327 12817007 15284024 15322115 23956138 24658140 24797263 25402006 31980649 7543024 7657660 7690989 details
STAT1_HUMANINAR2_HUMANBioGRID, HPRD, MINT11301323 29997210 32123171 9121453 details
STAT1_HUMANSTAT1_HUMANBioGRID, DIP, HPRD, MINT12873986 14704793 15284440 15780933 16007122 18591661 21914072 32814877 8605877 8621447 9630226 details
STAT1_HUMANIL6RB_HUMANMINT8662591 details
STAT1_HUMANSTAT3_HUMANBioGRID, DIP, HPRD, IntAct, MINT11594781 11722592 12070153 16007122 25241761 25609649 26966684 28514442 31462771 8662591 details
STAT1_HUMANACTN4_HUMANBioGRID, IntAct20936779 details
STAT1_HUMANDCTN1_HUMANBioGRID, IntAct20936779 details
STAT1_HUMANGFAP_HUMANBioGRID, IntAct20936779 details
STAT1_HUMANHS90B_HUMANBioGRID, IntAct20936779 details
STAT1_HUMANSHAN1_HUMANBioGRID, IntAct20936779 details
STAT1_HUMANSPTN1_HUMANBioGRID, IntAct, MINT20936779 26966684 details
STAT1_HUMANSPTB2_HUMANBioGRID, IntAct20936779 details
STAT1_HUMANDDB1_HUMANBioGRID, IntAct21988832 details
STAT1_HUMANHCDH_HUMANBioGRID, IntAct21988832 details
STAT1_HUMANHLAB_HUMANBioGRID, IntAct21988832 details
STAT1_HUMANNU4LM_HUMANBioGRID, IntAct21988832 details
STAT1_HUMANNCPR_HUMANBioGRID, IntAct21988832 details
STAT1_HUMANRXRA_HUMANBioGRID, IntAct21988832 details
STAT1_HUMANNOMO1_HUMANBioGRID, IntAct21988832 details
STAT1_HUMANNOMO2_HUMANBioGRID, IntAct21988832 details
STAT1_HUMANMAVS_HUMANBioGRID, IntAct21903422 details
STAT1_HUMANKIT_HUMANBioGRID, HPRD, IntAct25241761 9355737 details
STAT1_HUMANFAK1_HUMANBioGRID, IntAct11278462 20576130 25241761 details
STAT1_HUMANPIAS1_HUMANBioGRID, HPRD, IntAct10805787 11257227 12171910 12855578 17371985 18566411 25241761 9724754 details
STAT1_HUMANJAK2_HUMANBioGRID, HPRD, MINT10918587 11152457 11294897 11839738 12637327 12817007 14978237 15284024 15322115 19834108 20353823 24255956 7543024 7657660 7690989 details
STAT1_HUMANSPTB1_HUMANBioGRID, IntAct25814554 details
STAT1_HUMANIRF1_HUMANBioGRID, HPRD, IntAct, NTNU10764778 16512786 17525742 19124747 8810328 details
STAT1_HUMANOTUD4_HUMANBioGRID, IntAct25416956 details
STAT1_HUMANIMA5_HUMANBioGRID, HPRD, MINT10964507 12048190 17596301 26966684 details
STAT1_HUMANJAK1_HUMANBioGRID, HPRD, IntAct10918587 10982844 11294897 11722592 11839738 12637327 12817007 14978237 15284024 15322115 32123171 32814877 32953130 7543024 7657660 7690989 details
STAT1_HUMANLZTR1_HUMANBioGRID, IntAct20211142 details
STAT1_HUMANFANCC_HUMANBioGRID, HPRD10848598 11520787 14499622 details
STAT1_HUMANRACK1_HUMANBioGRID, HPRD11301323 12960323 details
STAT1_HUMANTYK2_HUMANBioGRID, HPRD10918587 11294897 11839738 12637327 12817007 12960323 15322115 7543024 7657660 7690989 details
STAT1_HUMANI27RA_HUMANBioGRID, HPRD12734330 details
STAT1_HUMANCBP_HUMANBioGRID, HPRD10848577 15695802 15894584 16481475 19915063 25451029 25733689 8986769 9037008 details
STAT1_HUMANE2AK2_HUMANBioGRID, HPRD11278865 9135145 details
STAT1_HUMANIL2RB_HUMANBioGRID, HPRD10602027 details
STAT1_HUMANMCM5_HUMANBioGRID, HPRD11248027 9843502 details
STAT1_HUMANVDR_HUMANBioGRID, HPRD11909970 details
STAT1_HUMANTRADD_HUMANBioGRID, HPRD10848577 details
STAT1_HUMANKPCD_HUMANBioGRID, HPRD11839738 11972023 12637327 12807916 12817007 14963018 15322115 19553685 7543024 7690989 9355737 details
STAT1_HUMANELP2_HUMANBioGRID, HPRD10954736 details
STAT1_HUMANGTF2I_HUMANBioGRID, HPRD9584171 details
STAT1_HUMANBRCA1_HUMANBioGRID, HPRD10792030 details
STAT1_HUMANATF3_HUMANBioGRID19647793 details
STAT1_HUMANDOT1L_HUMANBioGRID22002246 details
STAT1_HUMANUBC9_HUMANBioGRID, HPRD12356736 14517261 details
STAT1_HUMANANM1_HUMANBioGRID, HPRD11257227 12171910 details
STAT1_HUMANANM3_HUMANBioGRID11257227 details
STAT1_HUMANPK3CA_HUMANBioGRID11438544 details
STAT1_HUMANXPO1_HUMANBioGRID, HPRD22833565 26673895 9205132 details
STAT1_HUMANCASP3_HUMANBioGRID18723680 details
STAT1_HUMANCASP7_HUMANBioGRID18723680 details
STAT1_HUMANSTAT4_HUMANBioGRID21826217 details
STAT1_HUMANPTN11_HUMANBioGRID, HPRD12270932 27229929 details
STAT1_HUMANHSP7C_HUMANBioGRID19299420 27684187 details
STAT1_HUMANDUS2_HUMANBioGRID12270932 details
STAT1_HUMANSHPS1_HUMANBioGRID19299420 details
STAT1_HUMANFRIH_HUMANBioGRID19299420 details
STAT1_HUMANDDX6_HUMANBioGRID19299420 details
STAT1_HUMANCDC42_HUMANBioGRID31478661 details
STAT1_HUMANTP4A3_HUMANIntAct17353931 details
STAT1_HUMANUBE2F_HUMANIntAct17353931 details
STAT1_HUMANGSTK1_HUMANIntAct17353931 details
STAT1_HUMANINAR1_HUMANMINT9121453 details
STAT1_HUMANDNJA3_HUMANIntAct21106534 details
STAT1_HUMANPGFRA_HUMANBioGRID, HPRD, IntAct25241761 9484840 details
STAT1_HUMANMTOR_HUMANBioGRID, IntAct12807916 19553685 25241761 details
STAT1_HUMANFOS_HUMANBioGRID, HPRD, IntAct12788789 25241761 details
STAT1_HUMANTF65_HUMANBioGRID, HPRD, IntAct16481475 25241761 details
STAT1_HUMANSTA5A_HUMANBioGRID, HPRD, IntAct10358045 25241761 details
STAT1_HUMANCNOT7_HUMANMINT23386060 details
STAT1_HUMANPGFRB_HUMANHPRD, IntAct23397142 8549654 9484840 details
STAT1_HUMANDDX58_HUMANIntAct24360797 details
STAT1_HUMANKPCE_HUMANBioGRID, IntAct20353823 24825907 details
STAT1_HUMANKDM3A_HUMANDIP25535969 details
STAT1_HUMANIMA7_HUMANHPRD, MINT16298512 26966684 details
STAT1_HUMANEP300_HUMANBioGRID, HPRD10464260 11134049 11923478 12403783 15824515 18566411 19915063 26479788 26504087 8986769 9843502 details
STAT1_HUMANSRC_HUMANBioGRID, HPRD10358079 14978237 9344858 details
STAT1_HUMANHSF1_HUMANBioGRID, HPRD9880553 details
STAT1_HUMANTNR1A_HUMANBioGRID, HPRD10848577 details
STAT1_HUMANJUN_HUMANBioGRID, HPRD10490649 details
STAT1_HUMANRNF11_HUMANBioGRID19131965 details
STAT1_HUMANPTN2_HUMANBioGRID, HPRD12138178 12171910 14600148 19171783 details
STAT1_HUMANMBD1_HUMANBioGRID19074829 details
STAT1_HUMANBCL3_HUMANBioGRID16306601 details
STAT1_HUMANSMCA4_HUMANBioGRID16195385 20353823 21079652 details
STAT1_HUMANTIF1B_HUMANBioGRID18037959 18381204 details
STAT1_HUMANCTBL1_HUMANBioGRID21385873 details
STAT1_HUMANSMCA2_HUMANBioGRID21079652 details
STAT1_HUMANSMUF1_HUMANBioGRID22474288 details
STAT1_HUMANPRS6A_HUMANBioGRID19853614 details
STAT1_HUMANH32_HUMANBioGRID21689637 details
STAT1_HUMANHDAC4_HUMANBioGRID21571862 details
STAT1_HUMANISG15_HUMANBioGRID16009940 33024031 details
STAT1_HUMANIRAK1_HUMANBioGRID12856330 details
STAT1_HUMANIKBA_HUMANBioGRID16481475 details
STAT1_HUMANHDAC1_HUMANBioGRID16481475 details
STAT1_HUMANHDAC3_HUMANBioGRID16481475 details
STAT1_HUMANIGBP1_HUMANBioGRID19553685 details
STAT1_HUMANLST8_HUMANBioGRID19553685 details
STAT1_HUMANPTPA_HUMANBioGRID19553685 details
STAT1_HUMANKS6B1_HUMANBioGRID19553685 details
STAT1_HUMANUBP13_HUMANBioGRID23940278 details
STAT1_HUMANDTX3L_HUMANBioGRID24886089 26479788 details
STAT1_HUMANGBB2_HUMANBioGRID23326349 details
STAT1_HUMANPML_HUMANBioGRID25733689 25812002 details
STAT1_HUMANPARP9_HUMANBioGRID23487038 26479788 details
STAT1_HUMANH2B1J_HUMANBioGRID26479788 details
STAT1_HUMANPPARA_HUMANBioGRID26504087 details
STAT1_HUMANPPARD_HUMANBioGRID26504087 details
STAT1_HUMANPPARG_HUMANBioGRID26504087 details
STAT1_HUMANFANCE_HUMANBioGRID26277624 details
STAT1_HUMANU2AF2_HUMANBioGRID26641092 details
STAT1_HUMANITAV_HUMANBioGRID23640055 details
STAT1_HUMANENPL_HUMANBioGRID18662321 details
STAT1_HUMANACK1_HUMANBioGRID28739485 details
STAT1_HUMANUBP2_HUMANBioGRID27434509 details
STAT1_HUMANNR1H3_HUMANBioGRID27485016 details
STAT1_HUMANNR1H2_HUMANBioGRID27485016 details
STAT1_HUMANMAGA3_HUMANBioGRID30588194 details
STAT1_HUMANRNF31_HUMANBioGRID32123171 details
STAT1_HUMANOTUL_HUMANBioGRID32123171 details
STAT1_HUMANRN220_HUMANBioGRID32814877 details
STAT1_HUMANATG5_HUMANBioGRID33024031 details
STAT1_HUMANTNR1B_HUMANHPRD10848577 details
STAT1_HUMANBMX_HUMANHPRD9373245 details
STAT1_HUMANIL2RG_HUMANHPRD11418623 details
STAT1_HUMANXPO2_HUMANHPRD11927559 details
STAT1_HUMANKS6A5_HUMANHPRD14963018 details
STAT1_HUMANZN467_HUMANHPRD12426389 details
STAT1_HUMANMK14_HUMANHPRD11226159 details
STAT1_HUMANDUS3_HUMANHPRD11238845 details
STAT1_HUMANIL3RB_HUMANHPRD8631962 details
STAT1_HUMANMCM3_HUMANHPRD9843502 details
STAT1_HUMANKCC2D_HUMANHPRD11972023 details
STAT1_HUMANRAC1_HUMANHPRD15494521 details
STAT1_HUMANCXCR4_HUMANHPRD10506573 details
STAT1_HUMANVGFR2_HUMANHPRD10961983 details
STAT1_HUMANVGFR1_HUMANHPRD15703780 details
STAT1_HUMANCCR1_HUMANHPRD14674010 details
STAT1_HUMANCCR5_HUMANHPRD14674010 details
STAT1_HUMANFYN_HUMANHPRD9804857 details
STAT1_HUMANIRF2_HUMANHPRD15778351 details
STAT1_HUMANAKT1_HUMANHPRD15284024 details
STAT1_HUMANFADD_HUMANHPRD10848577 details
STAT1_HUMANSTA5B_HUMANHPRD10358045 details
STAT1_HUMANKSYK_HUMANHPRD15467722 details
STAT1_HUMANSUMO4_HUMANHPRD16236267 details
STAT1_HUMANFGFR3_HUMANHPRD10918587 11294897 11839738 12637327 12817007 15322115 7543024 7657660 7690989 details
STAT1_HUMANFGFR4_HUMANHPRD10918587 11294897 11839738 12637327 12817007 15322115 7543024 7657660 7690989 details
STAT1_HUMANADA1B_HUMANHPRD10652206 details
STAT1_HUMANLCK_HUMANHPRD10918587 11294897 11839738 12637327 12817007 15322115 7543024 7657660 7690989 details
STAT1_HUMANMK_HUMANHPRD9452495 details