Entity Details

Primary name TXK_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP42681
EntryNameTXK_HUMAN
FullNameTyrosine-protein kinase TXK
TaxID9606
Evidenceevidence at protein level
Length527
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesTXK

GO terms

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GOName
GO:0001819 positive regulation of cytokine production
GO:0002250 adaptive immune response
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0007202 activation of phospholipase C activity
GO:0007229 integrin-mediated signaling pathway
GO:0010468 regulation of gene expression
GO:0010543 regulation of platelet activation
GO:0032729 positive regulation of interferon-gamma production
GO:0038083 peptidyl-tyrosine autophosphorylation
GO:0042246 tissue regeneration
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046777 protein autophosphorylation
GO:0050852 T cell receptor signaling pathway
GO:0060335 positive regulation of interferon-gamma-mediated signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR035579 Tyrosine-protein kinase TXK, SH3 domainDomainDomain
IPR035870 Tyrosine-protein kinase TXK, SH2 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule
DB15035 ZanubrutinibDrugbanksmall molecule

Interactions

39 interactions

InteractorPartnerSourcesPublicationsLink
TXK_HUMANERBB2_HUMANBioGRID, MINT16273093 22973453 details
TXK_HUMANERBB3_HUMANBioGRID, MINT16273093 22973453 details
TXK_HUMANKIT_HUMANBioGRID, IntAct24728074 details
TXK_HUMANMET_HUMANBioGRID, IntAct24728074 details
TXK_HUMANCLNK_HUMANBioGRID, IntAct25814554 details
TXK_HUMANZN587_HUMANBioGRID, IntAct32296183 details
TXK_HUMANIKZF4_HUMANBioGRID, IntAct32296183 details
TXK_HUMANIKZF1_HUMANBioGRID, IntAct32296183 details
TXK_HUMANEFHC2_HUMANBioGRID, IntAct32296183 details
TXK_HUMANRBAK_HUMANBioGRID, IntAct32296183 details
TXK_HUMANCRK_HUMANBioGRID, IntAct32296183 details
TXK_HUMANNCK2_HUMANBioGRID, IntAct32296183 details
TXK_HUMANCBY2_HUMANBioGRID, IntAct32296183 details
TXK_HUMANP85A_HUMANBioGRID, IntAct32296183 details
TXK_HUMANZN835_HUMANBioGRID, IntAct32296183 details
TXK_HUMANZN792_HUMANBioGRID, IntAct32296183 details
TXK_HUMANDUS6_HUMANBioGRID, IntAct32296183 details
TXK_HUMANSOCS3_HUMANBioGRID, IntAct32296183 details
TXK_HUMANPRD14_HUMANBioGRID, IntAct32296183 details
TXK_HUMANSOCS6_HUMANBioGRID, IntAct32296183 details
TXK_HUMANJERKY_HUMANBioGRID, IntAct32296183 details
TXK_HUMANGRB10_HUMANBioGRID, IntAct32296183 details
TXK_HUMANGRB2_HUMANBioGRID, IntAct32296183 details
TXK_HUMANTENS4_HUMANBioGRID, IntAct32296183 details
TXK_HUMANDOK2_HUMANBioGRID, IntAct32296183 details
TXK_HUMANSTAP2_HUMANBioGRID, IntAct32296183 details
TXK_HUMANCCD33_HUMANBioGRID32296183 details
TXK_HUMANHOMEZ_HUMANBioGRID32296183 details
TXK_HUMANEGFR_HUMANBioGRID22973453 details
TXK_HUMANERBB4_HUMANBioGRID22973453 details
TXK_HUMANSH22A_HUMANHPRD10587356 details
TXK_HUMANSRC_HUMANHPRD11353545 details
TXK_HUMANTXK_HUMANHPRD12081135 details
TXK_HUMANCCR5_HUMANHPRD11859127 details
TXK_HUMANLCP2_HUMANHPRD10660534 8702662 9047237 details
TXK_HUMANYTDC1_HUMANHPRD15175272 details
TXK_HUMANCTLA4_HUMANHPRD9813138 details
TXK_HUMANNELFD_HUMANHPRD14684750 details
TXK_HUMANFYN_HUMANHPRD11353545 details