Entity Details

Primary name EAA3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP43005
EntryNameEAA3_HUMAN
FullNameExcitatory amino acid transporter 3
TaxID9606
Evidenceevidence at protein level
Length524
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesSLC1A1

GO terms

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GOName
GO:0001662 behavioral fear response
GO:0001975 response to amphetamine
GO:0005253 anion channel activity
GO:0005313 L-glutamate transmembrane transporter activity
GO:0005314 high-affinity glutamate transmembrane transporter activity
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006750 glutathione biosynthetic process
GO:0006801 superoxide metabolic process
GO:0006811 ion transport
GO:0006836 neurotransmitter transport
GO:0006882 cellular zinc ion homeostasis
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007212 dopamine receptor signaling pathway
GO:0007215 glutamate receptor signaling pathway
GO:0007268 chemical synaptic transmission
GO:0007420 brain development
GO:0007613 memory
GO:0007625 grooming behavior
GO:0007626 locomotory behavior
GO:0009986 cell surface
GO:0010460 positive regulation of heart rate
GO:0010467 gene expression
GO:0010842 retina layer formation
GO:0015108 chloride transmembrane transporter activity
GO:0015183 L-aspartate transmembrane transporter activity
GO:0015501 glutamate:sodium symporter activity
GO:0015813 L-glutamate transmembrane transport
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0016595 glutamate binding
GO:0018105 peptidyl-serine phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0022008 neurogenesis
GO:0030424 axon
GO:0030425 dendrite
GO:0030534 adult behavior
GO:0031901 early endosome membrane
GO:0031902 late endosome membrane
GO:0032148 activation of protein kinase B activity
GO:0032279 asymmetric synapse
GO:0033229 cysteine transmembrane transporter activity
GO:0035633 maintenance of blood-brain barrier
GO:0036293 response to decreased oxygen levels
GO:0036475 neuron death in response to oxidative stress
GO:0042417 dopamine metabolic process
GO:0042802 identical protein binding
GO:0042883 cysteine transport
GO:0043025 neuronal cell body
GO:0043083 synaptic cleft
GO:0043197 dendritic spine
GO:0043198 dendritic shaft
GO:0043204 perikaryon
GO:0043278 response to morphine
GO:0043524 negative regulation of neuron apoptotic process
GO:0043679 axon terminus
GO:0045121 membrane raft
GO:0046872 metal ion binding
GO:0048514 blood vessel morphogenesis
GO:0048678 response to axon injury
GO:0050808 synapse organization
GO:0051938 L-glutamate import
GO:0055038 recycling endosome membrane
GO:0060013 righting reflex
GO:0060047 heart contraction
GO:0060291 long-term synaptic potentiation
GO:0061744 motor behavior
GO:0070062 extracellular exosome
GO:0070633 transepithelial transport
GO:0070777 D-aspartate transport
GO:0070778 L-aspartate transmembrane transport
GO:0070779 D-aspartate import across plasma membrane
GO:0071242 cellular response to ammonium ion
GO:0071288 cellular response to mercury ion
GO:0071314 cellular response to cocaine
GO:0071407 cellular response to organic cyclic compound
GO:0071577 zinc ion transmembrane transport
GO:0071944 cell periphery
GO:0072347 response to anesthetic
GO:0090313 regulation of protein targeting to membrane
GO:0090461 glutamate homeostasis
GO:0097049 motor neuron apoptotic process
GO:0097386 glial cell projection
GO:0097440 apical dendrite
GO:0098712 L-glutamate import across plasma membrane
GO:0098793 presynapse
GO:0098877 neurotransmitter receptor transport to plasma membrane
GO:0099544 perisynaptic space
GO:0140009 L-aspartate import across plasma membrane
GO:0140010 D-aspartate transmembrane transporter activity
GO:0150002 distal dendrite
GO:0150104 transport across blood-brain barrier
GO:1902476 chloride transmembrane transport
GO:1990635 proximal dendrite
GO:1990708 conditioned place preference

Subcellular Location

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Subcellular Location
Apical cell membrane
Cell junction
Cell membrane
Early endosome membrane
Late endosome membrane
Recycling endosome membrane

Domains

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DomainNameCategoryType
IPR001991 Sodium:dicarboxylate symporterFamilyFamily
IPR018107 Sodium:dicarboxylate symporter, conserved siteSiteConserved site
IPR036458 Sodium:dicarboxylate symporter superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00128 Aspartic acidDrugbanksmall molecule
DB00142 Glutamic acidDrugbanksmall molecule
DB00230 PregabalinDrugbanksmall molecule