Entity Details

Primary name FNTB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP49356
EntryNameFNTB_HUMAN
FullNameProtein farnesyltransferase subunit beta
TaxID9606
Evidenceevidence at protein level
Length437
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GO terms

Show/Hide Table
GOName
GO:0000165 MAPK cascade
GO:0004660 protein farnesyltransferase activity
GO:0005829 cytosol
GO:0005875 microtubule associated complex
GO:0005965 protein farnesyltransferase complex
GO:0008270 zinc ion binding
GO:0018342 protein prenylation
GO:0018343 protein farnesylation
GO:0022400 regulation of rhodopsin mediated signaling pathway

Subcellular Location

Show/Hide Table

Domains

Show/Hide Table
DomainNameCategoryType
IPR001330 PFTB repeatRepeatRepeat
IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroidFamilyHomologous superfamily
IPR026872 Protein farnesyltransferase subunit betaFamilyFamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB04893 AZD3409Drugbanksmall molecule
DB04960 TipifarnibDrugbanksmall molecule
DB06448 LonafarnibDrugbanksmall molecule
DB06953 2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)- METHOXYMETHYL]-NICOTINONITRILEDrugbanksmall molecule
DB07216 (11S)-8-CHLORO-11-[1-(METHYLSULFONYL)PIPERIDIN-4-YL]-6-PIPERAZIN-1-YL-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINEDrugbanksmall molecule
DB07227 L-778123Drugbanksmall molecule
DB07771 [(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACIDDrugbanksmall molecule
DB07780 Farnesyl diphosphateDrugbanksmall molecule
DB07841 Geranylgeranyl diphosphateDrugbanksmall molecule
DB07895 ALPHA-HYDROXYFARNESYLPHOSPHONIC ACIDDrugbanksmall molecule
DB08674 (20S)-19,20,21,22-TETRAHYDRO-19-OXO-5H-18,20-ETHANO-12,14-ETHENO-6,10-METHENO-18H-BENZ[D]IMIDAZO[4,3-K][1,6,9,12]OXATRIAZA-CYCLOOCTADECOSINE-9-CARBONITRILEDrugbanksmall molecule
DB08676 (20S)-19,20,22,23-TETRAHYDRO-19-OXO-5H,21H-18,20-ETHANO-12,14-ETHENO-6,10-METHENOBENZ[D]IMIDAZO[4,3-L][1,6,9,13]OXATRIAZACYCLONOADECOSINE-9-CARBONITRILEDrugbanksmall molecule