Entity Details

Primary name NEK2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP51955
EntryNameNEK2_HUMAN
FullNameSerine/threonine-protein kinase Nek2
TaxID9606
Evidenceevidence at protein level
Length445
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesNEK2

GO terms

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GOName
GO:0000070 mitotic sister chromatid segregation
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0000776 kinetochore
GO:0000794 condensed nuclear chromosome
GO:0000922 spindle pole
GO:0001824 blastocyst development
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005874 microtubule
GO:0006468 protein phosphorylation
GO:0007059 chromosome segregation
GO:0007088 regulation of mitotic nuclear division
GO:0007096 regulation of exit from mitosis
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0019903 protein phosphatase binding
GO:0030496 midbody
GO:0032212 positive regulation of telomere maintenance via telomerase
GO:0032991 protein-containing complex
GO:0043392 negative regulation of DNA binding
GO:0046602 regulation of mitotic centrosome separation
GO:0046777 protein autophosphorylation
GO:0046872 metal ion binding
GO:0051225 spindle assembly
GO:0051299 centrosome separation
GO:0051301 cell division
GO:0051321 meiotic cell cycle
GO:0051973 positive regulation of telomerase activity
GO:0051988 regulation of attachment of spindle microtubules to kinetochore
GO:0090307 mitotic spindle assembly
GO:0097711 ciliary basal body-plasma membrane docking
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1903126 negative regulation of centriole-centriole cohesion
GO:1904355 positive regulation of telomere capping

Subcellular Location

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Subcellular Location
Chromosome
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB07180 5-[(Z)-(5-Chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N,2,4-trimethyl-1H-pyrrole-3-carboxamideDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

42 interactions

InteractorPartnerSourcesPublicationsLink
NEK2_HUMANNEK11_HUMANHPRD, IntAct15161910 details
NEK2_HUMANRHOB_HUMANIntAct19637314 details
NEK2_HUMANPP1G_HUMANBioGRID, IntAct21382349 23080069 24116158 24902662 details
NEK2_HUMANEDRF1_HUMANBioGRID, MINT21900206 details
NEK2_HUMANCC85A_HUMANBioGRID, MINT21900206 details
NEK2_HUMANCMGA_HUMANBioGRID, MINT21900206 details
NEK2_HUMANDCTN1_HUMANBioGRID, MINT21900206 details
NEK2_HUMANIF4A2_HUMANBioGRID, MINT21900206 details
NEK2_HUMANGIT1_HUMANBioGRID, MINT21900206 details
NEK2_HUMANIF140_HUMANBioGRID, MINT21900206 details
NEK2_HUMANMIC60_HUMANBioGRID, MINT21900206 details
NEK2_HUMANCRCM_HUMANBioGRID, MINT21900206 details
NEK2_HUMANNDC80_HUMANBioGRID, HPRD, MINT12386167 21900206 9295362 details
NEK2_HUMANMYOME_HUMANBioGRID, MINT21900206 details
NEK2_HUMANSPTN4_HUMANBioGRID, MINT21900206 details
NEK2_HUMANTCF25_HUMANBioGRID, MINT21900206 details
NEK2_HUMANTPM3_HUMANBioGRID, MINT21900206 details
NEK2_HUMANPP1A_HUMANBioGRID, HPRD, IntAct10880350 12221103 22321011 details
NEK2_HUMANNEK2_HUMANBioGRID, HPRD, MINT10347187 23288039 details
NEK2_HUMANKIF24_HUMANUniProt26290419 details
NEK2_HUMANPTPRD_HUMANBioGRID, MINT22305495 details
NEK2_HUMANMK01_HUMANBioGRID, HPRD15358203 details
NEK2_HUMANCP250_HUMANBioGRID, HPRD23443559 9647649 details
NEK2_HUMANCLC4C_HUMANBioGRID12386167 details
NEK2_HUMANIPP2_HUMANBioGRID, HPRD12221103 details
NEK2_HUMANCASB_HUMANBioGRID15147269 details
NEK2_HUMANCDC20_HUMANBioGRID23160376 25306918 25673878 32307883 details
NEK2_HUMANCTNB1_HUMANBioGRID24501426 details
NEK2_HUMANFZR1_HUMANBioGRID23160376 25673878 26387737 details
NEK2_HUMANPRKN_HUMANBioGRID26387737 details
NEK2_HUMANSMUF1_HUMANBioGRID20804422 details
NEK2_HUMANFANCA_HUMANBioGRID23806870 details
NEK2_HUMANMD1L1_HUMANHPRD14978040 details
NEK2_HUMANCDC27_HUMANBioGRID, IntAct16648845 25673878 29863498 32076268 details
NEK2_HUMANRITA1_HUMANMINT21102556 details
NEK2_HUMANAPC4_HUMANBioGRID, MINT23288039 25673878 25750436 29863498 details
NEK2_HUMANCHK1_HUMANBioGRID15311285 details
NEK2_HUMANMD2L1_HUMANBioGRID25673878 details
NEK2_HUMANBUB1B_HUMANBioGRID25673878 details
NEK2_HUMANUBP7_HUMANBioGRID29863498 details
NEK2_HUMANANC2_HUMANBioGRID29863498 32307883 details
NEK2_HUMANBECN1_HUMANBioGRID31955515 details