Entity Details

Primary name PPP5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP53041
EntryNamePPP5_HUMAN
FullNameSerine/threonine-protein phosphatase 5
TaxID9606
Evidenceevidence at protein level
Length499
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesPPP5C

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000278 mitotic cell cycle
GO:0001933 negative regulation of protein phosphorylation
GO:0001965 G-protein alpha-subunit binding
GO:0003723 RNA binding
GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006302 double-strand break repair
GO:0006351 transcription, DNA-templated
GO:0006470 protein dephosphorylation
GO:0008017 microtubule binding
GO:0008289 lipid binding
GO:0010288 response to lead ion
GO:0016576 histone dephosphorylation
GO:0016791 phosphatase activity
GO:0032991 protein-containing complex
GO:0035970 peptidyl-threonine dephosphorylation
GO:0042802 identical protein binding
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043204 perikaryon
GO:0043231 intracellular membrane-bounded organelle
GO:0043278 response to morphine
GO:0043531 ADP binding
GO:0044877 protein-containing complex binding
GO:0046872 metal ion binding
GO:0048156 tau protein binding
GO:0051879 Hsp90 protein binding
GO:0070262 peptidyl-serine dephosphorylation
GO:0070301 cellular response to hydrogen peroxide
GO:0071276 cellular response to cadmium ion
GO:0101031 chaperone complex
GO:0106306 protein serine phosphatase activity
GO:0106307 protein threonine phosphatase activity
GO:1901215 negative regulation of neuron death
GO:1904550 response to arachidonic acid
GO:1990635 proximal dendrite
GO:2000324 positive regulation of glucocorticoid receptor signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001440 Tetratricopeptide repeat 1RepeatRepeat
IPR004843 Calcineurin-like phosphoesterase domain, ApaH typeDomainDomain
IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphataseDomainDomain
IPR011236 Serine/threonine protein phosphatase 5FamilyFamily
IPR011990 Tetratricopeptide-like helical domain superfamilyFamilyHomologous superfamily
IPR013235 PPP domainDomainDomain
IPR019734 Tetratricopeptide repeatRepeatRepeat
IPR029052 Metallo-dependent phosphatase-likeFamilyHomologous superfamily
IPR041753 PP5, C-terminal metallophosphatase domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00171 ATPDrugbanksmall molecule

Interactions

44 interactions

InteractorPartnerSourcesPublicationsLink
PPP5_HUMANXPO2_HUMANBioGRID, HPRD, IntAct16169070 details
PPP5_HUMANDISC1_HUMANBioGRID, IntAct17043677 31413325 details
PPP5_HUMANESR2_HUMANBioGRID, IntAct14764652 details
PPP5_HUMANESR1_HUMANBioGRID, IntAct14764652 details
PPP5_HUMANHS90A_HUMANBioGRID, HPRD, IntAct10400612 15383005 16531226 19740745 19875381 20661446 21235734 21360678 25036637 26496610 27353360 27880917 28330616 9195923 details
PPP5_HUMANCDC37_HUMANBioGRID, IntAct21360678 25036637 28330616 29141220 details
PPP5_HUMANHS90B_HUMANBioGRID, DIP, IntAct16531226 21360678 25036637 26496610 27880917 28330616 details
PPP5_HUMANEGFR_HUMANBioGRID, IntAct20029029 31980649 details
PPP5_HUMANM3K7_HUMANBioGRID, MINT21900206 details
PPP5_HUMAN2AAA_HUMANHPRD, MINT11504734 details
PPP5_HUMANCHRD1_HUMANBioGRID, HPRD, IntAct16083881 23414517 25036637 details
PPP5_HUMAN5HT2A_HUMANDIP, HPRD16537434 details
PPP5_HUMANCRY2_HUMANBioGRID, DIP, HPRD16790549 9383998 details
PPP5_HUMANCDC27_HUMANBioGRID, HPRD9405394 details
PPP5_HUMANGNA12_HUMANBioGRID, HPRD12176367 details
PPP5_HUMANGNA13_HUMANBioGRID, HPRD12176367 details
PPP5_HUMANM3K5_HUMANBioGRID, HPRD11689443 details
PPP5_HUMANCDK20_HUMANBioGRID16954377 details
PPP5_HUMANA4_HUMANBioGRID21832049 details
PPP5_HUMANTAU_HUMANBioGRID, HPRD12435421 1330687 15546861 16262633 details
PPP5_HUMANHUWE1_HUMANBioGRID23652204 details
PPP5_HUMANKC1D_HUMANBioGRID29141220 details
PPP5_HUMANVHL_HUMANBioGRID29141220 details
PPP5_HUMANTP53B_HUMANBioGRID19176521 details
PPP5_HUMANOGT1_HUMANBioGRID32994395 details
PPP5_HUMANCDC16_HUMANHPRD9405394 details
PPP5_HUMANCPNE1_HUMANHPRD12522145 details
PPP5_HUMANCPNE2_HUMANHPRD12522145 details
PPP5_HUMANSTIP1_HUMANBioGRID, IntAct21360678 28330616 details
PPP5_HUMANPPP5_HUMANHPRD, IntAct15155720 21360678 details
PPP5_HUMANP2R3A_HUMANHPRD, MINT11504734 details
PPP5_HUMANTEBP_HUMANBioGRID, IntAct20661446 25036637 28330616 details
PPP5_HUMANNOL9_HUMANBioGRID, IntAct28330616 details
PPP5_HUMANAGO1_HUMANBioGRID, IntAct28330616 details
PPP5_HUMANAGO3_HUMANBioGRID, IntAct28330616 details
PPP5_HUMANCDK9_HUMANBioGRID, IntAct28330616 details
PPP5_HUMANCLUS_HUMANIntAct31413325 details
PPP5_HUMANHSP74_HUMANBioGRID15383005 details
PPP5_HUMANGCR_HUMANBioGRID20661446 details
PPP5_HUMANMCR_HUMANBioGRID20661446 details
PPP5_HUMANPRGR_HUMANBioGRID20661446 details
PPP5_HUMANANDR_HUMANBioGRID20661446 details
PPP5_HUMANFLCN_HUMANBioGRID27353360 details
PPP5_HUMANCPNE4_HUMANHPRD12522145 details