Entity Details

Primary name EPHA5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP54756
EntryNameEPHA5_HUMAN
FullNameEphrin type-A receptor 5
TaxID9606
Evidenceevidence at protein level
Length1037
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesEPHA5

GO terms

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GOName
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005003 ephrin receptor activity
GO:0005004 GPI-linked ephrin receptor activity
GO:0005005 transmembrane-ephrin receptor activity
GO:0005524 ATP binding
GO:0005791 rough endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0007411 axon guidance
GO:0009897 external side of plasma membrane
GO:0019933 cAMP-mediated signaling
GO:0021766 hippocampus development
GO:0030424 axon
GO:0030425 dendrite
GO:0032793 positive regulation of CREB transcription factor activity
GO:0032956 regulation of actin cytoskeleton organization
GO:0033674 positive regulation of kinase activity
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043087 regulation of GTPase activity
GO:0043235 receptor complex
GO:0048013 ephrin receptor signaling pathway
GO:0048471 perinuclear region of cytoplasm
GO:0048666 neuron development
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001090 Ephrin receptor ligand binding domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001426 Tyrosine-protein kinase, receptor class V, conserved siteSiteConserved site
IPR001660 Sterile alpha motif domainDomainDomain
IPR003961 Fibronectin type IIIDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR008979 Galactose-binding-like domain superfamilyFamilyHomologous superfamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013761 Sterile alpha motif/pointed domain superfamilyFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR016257 Ephrin receptor type-A /type-BFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR027936 Ephrin receptor, transmembrane domainDomainDomain
IPR034277 Ephrin type-A receptor 5, ligand binding domainDomainDomain
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01254 DasatinibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule