Entity Details

Primary name BID_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP55957
EntryNameBID_HUMAN
FullNameBH3-interacting domain death agonist
TaxID9606
Evidenceevidence at protein level
Length195
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesBID

GO terms

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GOName
GO:0001836 release of cytochrome c from mitochondria
GO:0005123 death receptor binding
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005829 cytosol
GO:0006626 protein targeting to mitochondrion
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0008637 apoptotic mitochondrial changes
GO:0010918 positive regulation of mitochondrial membrane potential
GO:0016020 membrane
GO:0031334 positive regulation of protein-containing complex assembly
GO:0031625 ubiquitin protein ligase binding
GO:0032592 integral component of mitochondrial membrane
GO:0042127 regulation of cell population proliferation
GO:0042770 signal transduction in response to DNA damage
GO:0042775 mitochondrial ATP synthesis coupled electron transport
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0051402 neuron apoptotic process
GO:0065003 protein-containing complex assembly
GO:0090150 establishment of protein localization to membrane
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:0097284 hepatocyte apoptotic process
GO:0097345 mitochondrial outer membrane permeabilization
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:2000045 regulation of G1/S transition of mitotic cell cycle
GO:2000271 positive regulation of fibroblast apoptotic process
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion membrane
Mitochondrion outer membrane

Domains

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DomainNameCategoryType
IPR010479 BH3-interacting domain death agonistFamilyFamily
IPR020728 Apoptosis regulator, Bcl-2, BH3 motif, conserved siteSiteConserved site
IPR036834 Bcl-2-like superfamilyFamilyHomologous superfamily

Diseases

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Interactions

52 interactions

InteractorPartnerSourcesPublicationsLink
BID_HUMANBCL2_HUMANBioGRID, DIP, HPRD, IntAct11583631 12624108 15520201 15694340 16697956 17289999 18835031 19074266 9463381 9727491 details
BID_HUMANBAK_HUMANBioGRID, DIP, HPRD, IntAct, Molecular Connections10950869 12624108 23604079 23782464 25408501 details
BID_HUMANB2CL1_HUMANBioGRID, DIP, HPRD, IntAct14963330 15574335 15694340 15721256 16697956 17289999 19074440 24814347 25241761 details
BID_HUMANB2CL2_HUMANBioGRID, HPRD, IntAct15694340 16697956 17289999 28514442 details
BID_HUMANMCL1_HUMANBioGRID, DIP, HPRD, IntAct15637055 15694340 16697956 19074266 21613222 details
BID_HUMANB2LA1_HUMANBioGRID, HPRD, IntAct11929871 16697956 details
BID_HUMANERG28_HUMANBioGRID, MINT21900206 details
BID_HUMANRBM48_HUMANBioGRID, MINT21900206 details
BID_HUMANDPYL1_HUMANBioGRID, MINT21900206 details
BID_HUMANCRNL1_HUMANBioGRID, MINT21900206 details
BID_HUMANFBN3_HUMANBioGRID, MINT21900206 details
BID_HUMANG3P_HUMANBioGRID, MINT21900206 details
BID_HUMANGBP2_HUMANBioGRID, MINT21900206 details
BID_HUMANPKHM1_HUMANBioGRID, MINT21900206 details
BID_HUMANSETB1_HUMANBioGRID, MINT21900206 details
BID_HUMANTLE1_HUMANBioGRID, MINT21900206 details
BID_HUMANTBB2B_HUMANBioGRID, MINT21900206 details
BID_HUMANZHX1_HUMANBioGRID, MINT21900206 details
BID_HUMANBAX_HUMANBioGRID, DIP, HPRD, IntAct15574335 17289999 20956295 23374347 25241761 details
BID_HUMANSAHH2_HUMANBioGRID, IntAct25416956 details
BID_HUMANREL_HUMANBioGRID, IntAct25416956 details
BID_HUMANDDT4L_HUMANBioGRID, IntAct32296183 details
BID_HUMANCASP3_HUMANBioGRID, DIP, HPRD10364179 11399776 18723680 details
BID_HUMANCASP8_HUMANBioGRID, HPRD11085743 11832478 12097160 12196516 15659383 9727491 9727492 details
BID_HUMANCAN2_HUMANBioGRID12000759 details
BID_HUMANCASP2_HUMANBioGRID, HPRD11399776 11832478 details
BID_HUMANRFA1_HUMANBioGRID21859891 details
BID_HUMANGRAB_HUMANBioGRID, HPRD11085743 17283187 9727491 details
BID_HUMAN1433B_HUMANHPRD, MINT12871587 details
BID_HUMANCAV1_HUMANBioGRID, IntAct21382479 details
BID_HUMANBID_HUMANBioGRID, HPRD, IntAct11805084 17289999 details
BID_HUMANRHOA_HUMANBioGRID, IntAct15659383 25241761 details
BID_HUMANFADD_HUMANBioGRID, IntAct15659383 25241761 details
BID_HUMANTNR6_HUMANBioGRID, IntAct15659383 25241761 details
BID_HUMANTNFL6_HUMANBioGRID, IntAct15659383 25241761 details
BID_HUMANKC1E_HUMANBioGRID, HPRD, IntAct11583622 25241761 details
BID_HUMANEZRI_HUMANBioGRID15659383 details
BID_HUMANMOES_HUMANBioGRID15659383 details
BID_HUMANGDIR1_HUMANBioGRID15659383 details
BID_HUMANTR10B_HUMANBioGRID15659383 details
BID_HUMANMK08_HUMANBioGRID15659383 details
BID_HUMANCASPA_HUMANBioGRID, HPRD15659383 15772077 details
BID_HUMANTNR1A_HUMANBioGRID15659383 details
BID_HUMANITCH_HUMANBioGRID20392206 details
BID_HUMANRFA2_HUMANBioGRID21859891 details
BID_HUMANSQSTM_HUMANBioGRID23333919 details
BID_HUMANKC1A_HUMANHPRD11583622 details
BID_HUMANCAN1_HUMANHPRD12000759 details
BID_HUMANCSK21_HUMANHPRD11583622 details
BID_HUMANCSK2B_HUMANHPRD11583622 details
BID_HUMANCSK22_HUMANHPRD11583622 details
BID_HUMANCASP1_HUMANHPRD11085743 9727491 details