Entity Details

Primary name BACE1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP56817
EntryNameBACE1_HUMAN
FullNameBeta-secretase 1
TaxID9606
Evidenceevidence at protein level
Length501
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesBACE1

GO terms

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GOName
GO:0004175 endopeptidase activity
GO:0005770 late endosome
GO:0005771 multivesicular body
GO:0005788 endoplasmic reticulum lumen
GO:0005802 trans-Golgi network
GO:0009314 response to radiation
GO:0042987 amyloid precursor protein catabolic process
GO:0045121 membrane raft
GO:0050966 detection of mechanical stimulus involved in sensory perception of pain
GO:0060134 prepulse inhibition
GO:0071280 cellular response to copper ion
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0016021 integral component of membrane
GO:0016485 protein processing
GO:0030424 axon
GO:0030659 cytoplasmic vesicle membrane
GO:0071287 cellular response to manganese ion
GO:1904646 cellular response to amyloid-beta
GO:1990000 amyloid fibril formation
GO:0001540 amyloid-beta binding
GO:0005764 lysosome
GO:0005768 endosome
GO:0005769 early endosome
GO:0005794 Golgi apparatus
GO:0006509 membrane protein ectodomain proteolysis
GO:0008021 synaptic vesicle
GO:0030425 dendrite
GO:0034205 amyloid-beta formation
GO:0043025 neuronal cell body
GO:0055037 recycling endosome
GO:2000300 regulation of synaptic vesicle exocytosis
GO:0004190 aspartic-type endopeptidase activity
GO:0005887 integral component of plasma membrane
GO:0006508 proteolysis
GO:0008233 peptidase activity
GO:0009986 cell surface
GO:0010288 response to lead ion
GO:0016020 membrane
GO:0019899 enzyme binding
GO:0043525 positive regulation of neuron apoptotic process
GO:0050435 amyloid-beta metabolic process
GO:0070931 Golgi-associated vesicle lumen
GO:0098686 hippocampal mossy fiber to CA3 synapse

Subcellular Location

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Subcellular Location
Early endosome
Endoplasmic reticulum
Golgi apparatus
Late endosome
Cell projection
Endosome
Lysosome
Cell membrane
Cell surface
Cytoplasmic vesicle membrane
Membrane raft
Recycling endosome

Domains

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DomainNameCategoryType
IPR001461 Aspartic peptidase A1 familyFamilyFamily
IPR001969 Aspartic peptidase, active siteSiteActive site
IPR009119 Beta-secretase BACEFamilyFamily
IPR009120 Beta-secretase BACE1FamilyFamily
IPR021109 Aspartic peptidase domain superfamilyFamilyHomologous superfamily
IPR033121 Peptidase family A1 domainDomainDomain
IPR033874 Memapsin-likeDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB02378 MMI-175Drugbanksmall molecule
DB06073 CTS-21166Drugbanksmall molecule
DB06930 N-[amino(imino)methyl]-2-(2,5-diphenyl-1H-pyrrol-1-yl)acetamideDrugbanksmall molecule
DB07019 N-[(5R,14R)-5-AMINO-5,14-DIMETHYL-4-OXO-3-OXA-18-AZATRICYCLO[15.3.1.1~7,11~]DOCOSA-1(21),7(22),8,10,17,19-HEXAEN-19-YL]-N-METHYLMETHANESULFONAMIDEDrugbanksmall molecule
DB07089 N-[amino(imino)methyl]-2-[2-(2-chlorophenyl)-4-(4-propoxyphenyl)-3-thienyl]acetamideDrugbanksmall molecule
DB07110 4-(4-FLUOROBENZYL)PIPERIDINEDrugbanksmall molecule
DB07175 N-{2-methyl-5-[(6-phenylpyrimidin-4-yl)amino]phenyl}methanesulfonamideDrugbanksmall molecule
DB07206 6-[2-(1H-INDOL-6-YL)ETHYL]PYRIDIN-2-AMINEDrugbanksmall molecule
DB07245 6-[2-(3'-METHOXYBIPHENYL-3-YL)ETHYL]PYRIDIN-2-AMINEDrugbanksmall molecule
DB07281 N~3~-BENZYLPYRIDINE-2,3-DIAMINEDrugbanksmall molecule
DB07284 N~3~-(3-PYRIDIN-3-YLBENZYL)PYRIDINE-2,3-DIAMINEDrugbanksmall molecule
DB07303 N~3~-[3-(5-METHOXYPYRIDIN-3-YL)BENZYL]PYRIDINE-2,3-DIAMINEDrugbanksmall molecule
DB07345 4-(2-aminoethyl)-2-cyclohexylphenolDrugbanksmall molecule
DB07346 4-(2-aminoethyl)-2-ethylphenolDrugbanksmall molecule
DB07415 4-[(1S)-1-(3-fluoro-4-methoxyphenyl)-2-(2-methoxy-5-nitrophenyl)ethyl]-1H-imidazol-2-amineDrugbanksmall molecule
DB07519 (6R)-2-amino-6-[2-(3'-methoxybiphenyl-3-yl)ethyl]-3,6-dimethyl-5,6-dihydropyrimidin-4(3H)-oneDrugbanksmall molecule
DB07535 2-amino-6-[2-(1H-indol-6-yl)ethyl]pyrimidin-4(3H)-oneDrugbanksmall molecule
DB07573 (2S)-1-(2,5-dimethylphenoxy)-3-morpholin-4-ylpropan-2-olDrugbanksmall molecule
DB07734 N-(1-benzylpiperidin-4-yl)-4-sulfanylbutanamideDrugbanksmall molecule
DB07735 N-[1-(2,6-dimethoxybenzyl)piperidin-4-yl]-4-sulfanylbutanamideDrugbanksmall molecule
DB07736 (2S)-4-(4-fluorobenzyl)-N-(2-sulfanylethyl)piperazine-2-carboxamideDrugbanksmall molecule
DB07737 (2S)-4-(4-fluorobenzyl)-N-(3-sulfanylpropyl)piperazine-2-carboxamideDrugbanksmall molecule
DB07738 N-[1-(5-bromo-2,3-dimethoxybenzyl)piperidin-4-yl]-4-sulfanylbutanamideDrugbanksmall molecule
DB07874 (6S)-2-amino-6-(3'-methoxybiphenyl-3-yl)-3,6-dimethyl-5,6-dihydropyrimidin-4(3H)-oneDrugbanksmall molecule
DB07993 N~3~-[3-(1H-INDOL-6-YL)BENZYL]PYRIDINE-2,3-DIAMINEDrugbanksmall molecule
DB07994 N~3~-[5-(1H-INDOL-6-YL)-2-(PYRIDIN-2-YLMETHOXY)BENZYL]PYRIDINE-2,3-DIAMINEDrugbanksmall molecule
DB08749 3-(2-AMINO-6-BENZOYLQUINAZOLIN-3(4H)-YL)-N-CYCLOHEXYL-N-METHYLPROPANAMIDEDrugbanksmall molecule
DB12285 VerubecestatDrugbanksmall molecule

Interactions

39 interactions

InteractorPartnerSourcesPublicationsLink
BACE1_HUMANA4_HUMANBioGRID, HPRD, IntAct, UniProt10531052 10677483 12901838 16407538 19251705 22801501 28869759 30538620 31996371 32814053 details
BACE1_HUMANADRB2_HUMANBioGRID, MINT28298427 details
BACE1_HUMANKCNC4_HUMANBioGRID, UniProt29507146 details
BACE1_HUMANPDIA3_HUMANHPRD, UniProt15606899 20354142 details
BACE1_HUMANIAPP_HUMANUniProt26840340 details
BACE1_HUMANGGA1_HUMANBioGRID, UniProt14567678 15117318 15466887 15886016 26053850 details
BACE1_HUMANGGA2_HUMANBioGRID, HPRD, UniProt12135764 14567678 26053850 details
BACE1_HUMANGGA3_HUMANBioGRID, UniProt14567678 26053850 details
BACE1_HUMANADA10_HUMANUniProt30538620 details
BACE1_HUMANPSN1_HUMANHPRD, UniProt12901838 details
BACE1_HUMANNICA_HUMANBioGRID, HPRD12054507 details
BACE1_HUMANFBX2_HUMANBioGRID20854419 details
BACE1_HUMANPCSK9_HUMANBioGRID18660751 details
BACE1_HUMANBRI3_HUMANBioGRID, HPRD15606899 details
BACE1_HUMANRANB9_HUMANBioGRID, HPRD15606899 19251705 details
BACE1_HUMANCHIP_HUMANBioGRID25773675 details
BACE1_HUMANUBP8_HUMANBioGRID27302062 details
BACE1_HUMANHYOU1_HUMANBioGRID29266373 details
BACE1_HUMANFUBP2_HUMANHPRD15606899 details
BACE1_HUMANKCY_HUMANHPRD15606899 details
BACE1_HUMANSAP_HUMANHPRD15606899 details
BACE1_HUMANAT1B1_HUMANHPRD15606899 details
BACE1_HUMANPLS1_HUMANHPRD12586838 details
BACE1_HUMANMMP2_HUMANBioGRID, HPRD, IntAct12586836 25241761 details
BACE1_HUMANKC1D_HUMANBioGRID, HPRD, IntAct11278841 25241761 details
BACE1_HUMANFLOT2_HUMANMINT24612608 details
BACE1_HUMANFLOT1_HUMANMINT24612608 details
BACE1_HUMANRTN4_HUMANBioGRID, UniProt16965550 details
BACE1_HUMANRTN3_HUMANBioGRID, UniProt16965550 details
BACE1_HUMANTMX1_HUMANBioGRID, UniProt20354142 29932915 details
BACE1_HUMANSNX6_HUMANUniProt20354142 details
BACE1_HUMANITM2B_HUMANUniProt23701002 details
BACE1_HUMANCSN5_HUMANBioGRID23926111 details
BACE1_HUMANSORT_HUMANBioGRID21245145 details
BACE1_HUMANKCNQ1_HUMANBioGRID26454161 details
BACE1_HUMANTNR16_HUMANBioGRID28869759 details
BACE1_HUMANITM2C_HUMANHPRD15606899 details
BACE1_HUMANLRP1_HUMANHPRD15749709 details
BACE1_HUMANFURIN_HUMANHPRD10887202 details