Entity Details

Primary name NLRP6_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP59044
EntryNameNLRP6_HUMAN
FullNameNACHT, LRR and PYD domains-containing protein 6
TaxID9606
Evidenceevidence at protein level
Length892
SequenceStatuscomplete
DateCreated2002-10-19
DateModified2021-06-02

Ontological Relatives

GenesNLRP6

GO terms

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GOName
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0005000 vasopressin receptor activity
GO:0005524 ATP binding
GO:0005886 plasma membrane
GO:0006954 inflammatory response
GO:0009617 response to bacterium
GO:0010506 regulation of autophagy
GO:0031965 nuclear membrane
GO:0034122 negative regulation of toll-like receptor signaling pathway
GO:0042060 wound healing
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response
GO:0050727 regulation of inflammatory response
GO:0061702 inflammasome complex
GO:0070255 regulation of mucus secretion
GO:0070373 negative regulation of ERK1 and ERK2 cascade

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Inflammasome
Nucleus membrane

Domains

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DomainNameCategoryType
IPR004020 DAPIN domainDomainDomain
IPR007111 NACHT nucleoside triphosphataseDomainDomain
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR032675 Leucine-rich repeat domain superfamilyFamilyHomologous superfamily
IPR041075 NOD2, winged helix domainDomainDomain
IPR041267 NACHT, LRR and PYD domains-containing protein, helical domain HD2DomainDomain

Diseases

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Interactions

3 interactions