Entity Details

Primary name IL2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP60568
EntryNameIL2_HUMAN
FullNameInterleukin-2
TaxID9606
Evidenceevidence at protein level
Length153
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesIL2

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001933 negative regulation of protein phosphorylation
GO:0002250 adaptive immune response
GO:0002366 leukocyte activation involved in immune response
GO:0002639 positive regulation of immunoglobulin production
GO:0002903 negative regulation of B cell apoptotic process
GO:0005125 cytokine activity
GO:0005134 interleukin-2 receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0006955 immune response
GO:0007155 cell adhesion
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0008083 growth factor activity
GO:0008284 positive regulation of cell population proliferation
GO:0010467 gene expression
GO:0019209 kinase activator activity
GO:0019221 cytokine-mediated signaling pathway
GO:0030101 natural killer cell activation
GO:0030217 T cell differentiation
GO:0030246 carbohydrate binding
GO:0030307 positive regulation of cell growth
GO:0030890 positive regulation of B cell proliferation
GO:0031851 kappa-type opioid receptor binding
GO:0032729 positive regulation of interferon-gamma production
GO:0032740 positive regulation of interleukin-17 production
GO:0034105 positive regulation of tissue remodeling
GO:0038110 interleukin-2-mediated signaling pathway
GO:0042104 positive regulation of activated T cell proliferation
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0043066 negative regulation of apoptotic process
GO:0043208 glycosphingolipid binding
GO:0045471 response to ethanol
GO:0045589 regulation of regulatory T cell differentiation
GO:0045591 positive regulation of regulatory T cell differentiation
GO:0045822 negative regulation of heart contraction
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046013 regulation of T cell homeostatic proliferation
GO:0048304 positive regulation of isotype switching to IgG isotypes
GO:0050672 negative regulation of lymphocyte proliferation
GO:0050728 negative regulation of inflammatory response
GO:0050729 positive regulation of inflammatory response
GO:0060999 positive regulation of dendritic spine development
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:1900100 positive regulation of plasma cell differentiation
GO:2000320 negative regulation of T-helper 17 cell differentiation

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000779 Interleukin-2FamilyFamily
IPR009079 Four-helical cytokine-like, coreFamilyHomologous superfamily
IPR030477 Interleukin-2, conserved siteSiteConserved site

Diseases

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Drugs

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DrugNameSourceType
DB00852 PseudoephedrineDrugbanksmall molecule
DB01327 CefazolinDrugbanksmall molecule
DB02555 SP4160Drugbanksmall molecule
DB02581 N(2)-carbamimidoyl-N-{2-[4-(3-{4-[(5-carboxyfuran-2-yl)methoxy]-2,3-dichlorophenyl}-1-methyl-1H-pyrazol-5-yl)piperidin-1-yl]-2-oxoethyl}-D-leucinamideDrugbanksmall molecule
DB03372 3-Mercapto-1-(1,3,4,9-Tetrahydro-B-Carbolin-2-Yl)-Propan-1-OneDrugbanksmall molecule
DB03453 Methyl (2S)-2-[[2-[(3R)-1-carbamimidoylpiperidin-3-yl]acetyl]amino]-3-[4-(2-phenylethynyl)phenyl]propanoateDrugbanksmall molecule
DB03455 (1H-indol-3-yl)-(2-mercapto-ethoxyimino)-acetic acidDrugbanksmall molecule
DB03957 SP2456Drugbanksmall molecule
DB04278 2-[2-(2-Cyclohexyl-2-guanidino-acetylamino)-acetylamino]-N-(3-mercapto-propyl)-propionamideDrugbanksmall molecule
DB05299 keyhole limpet hemocyaninDrugbankbiotech
DB05304 GirentuximabDrugbankbiotech
DB06083 TapinarofDrugbanksmall molecule
DB06584 TG4010Drugbankbiotech