Entity Details

Primary name HEPC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP81172
EntryNameHEPC_HUMAN
FullNameHepcidin
TaxID9606
Evidenceevidence at protein level
Length84
SequenceStatuscomplete
DateCreated1998-12-15
DateModified2021-06-02

Ontological Relatives

GenesHAMP

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0002092 positive regulation of receptor internalization
GO:0002262 myeloid cell homeostasis
GO:0005102 signaling receptor binding
GO:0005179 hormone activity
GO:0005507 copper ion binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0006879 cellular iron ion homeostasis
GO:0006953 acute-phase response
GO:0006955 immune response
GO:0007259 receptor signaling pathway via JAK-STAT
GO:0007568 aging
GO:0010039 response to iron ion
GO:0010043 response to zinc ion
GO:0014704 intercalated disc
GO:0031640 killing of cells of other organism
GO:0032413 negative regulation of ion transmembrane transporter activity
GO:0033189 response to vitamin A
GO:0034760 negative regulation of iron ion transmembrane transport
GO:0036017 response to erythropoietin
GO:0042742 defense response to bacterium
GO:0043032 positive regulation of macrophage activation
GO:0045179 apical cortex
GO:0045471 response to ethanol
GO:0045779 negative regulation of bone resorption
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050728 negative regulation of inflammatory response
GO:0050829 defense response to Gram-negative bacterium
GO:0050830 defense response to Gram-positive bacterium
GO:0050832 defense response to fungus
GO:0060586 multicellular organismal iron ion homeostasis
GO:0061051 positive regulation of cell growth involved in cardiac muscle cell development
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
GO:0071222 cellular response to lipopolysaccharide
GO:0071354 cellular response to interleukin-6
GO:0071356 cellular response to tumor necrosis factor
GO:0071481 cellular response to X-ray
GO:0097421 liver regeneration
GO:0097690 iron ion transmembrane transporter inhibitor activity
GO:1902916 positive regulation of protein polyubiquitination
GO:1903364 positive regulation of cellular protein catabolic process
GO:1903413 cellular response to bile acid
GO:1904039 negative regulation of iron export across plasma membrane
GO:1904255 negative regulation of iron ion transmembrane transporter activity
GO:1904479 negative regulation of intestinal absorption
GO:1990641 response to iron ion starvation
GO:2000646 positive regulation of receptor catabolic process

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR010500 HepcidinFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB13257 Ferrous sulfate anhydrousDrugbanksmall molecule

Interactions

4 interactions