Entity Details

Primary name PO5F1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ01860
EntryNamePO5F1_HUMAN
FullNamePOU domain, class 5, transcription factor 1
TaxID9606
Evidenceevidence at protein level
Length360
SequenceStatuscomplete
DateCreated1993-07-01
DateModified2021-06-02

Ontological Relatives

GenesPOU5F1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001714 endodermal cell fate specification
GO:0001824 blastocyst development
GO:0003130 BMP signaling pathway involved in heart induction
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0003723 RNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0008134 transcription factor binding
GO:0009611 response to wounding
GO:0009653 anatomical structure morphogenesis
GO:0009786 regulation of asymmetric cell division
GO:0010468 regulation of gene expression
GO:0031625 ubiquitin protein ligase binding
GO:0035019 somatic stem cell population maintenance
GO:0035198 miRNA binding
GO:0043565 sequence-specific DNA binding
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0060391 positive regulation of SMAD protein signal transduction
GO:0060795 cell fate commitment involved in formation of primary germ layer
GO:0060913 cardiac cell fate determination
GO:0060965 negative regulation of gene silencing by miRNA
GO:0090081 regulation of heart induction by regulation of canonical Wnt signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0090308 regulation of DNA methylation-dependent heterochromatin assembly
GO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000327 POU-specific domainDomainDomain
IPR001356 Homeobox domainDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR010982 Lambda repressor-like, DNA-binding domain superfamilyFamilyHomologous superfamily
IPR013847 POU domainDomainDomain
IPR015585 POU domain-containing protein, class 5FamilyFamily
IPR017970 Homeobox, conserved siteSiteConserved site

Diseases

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Drugs

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DrugNameSourceType
DB00368 NorepinephrineDrugbanksmall molecule
DB00988 DopamineDrugbanksmall molecule

Interactions

36 interactions

InteractorPartnerSourcesPublicationsLink
PO5F1_HUMANFOXD3_HUMANBioGRID, HPRD, IntAct11891324 details
PO5F1_HUMANWWP2_HUMANbhf-ucl, BioGRID19274063 19997087 22387393 29393344 details
PO5F1_HUMANSOX2_HUMANbhf-ucl, BioGRID, HPRD, IntAct, MINT12923055 19736317 20505756 23539445 25702638 26687479 30442713 details
PO5F1_HUMANLRRK2_HUMANBioGRID, IntAct29513927 details
PO5F1_HUMANGEMI_HUMANIntAct22615398 details
PO5F1_HUMANMAT1_HUMANBioGRID, HPRD9368058 details
PO5F1_HUMANWDR5_HUMANBioGRID21477851 details
PO5F1_HUMANNR0B1_HUMANBioGRID19528230 details
PO5F1_HUMANITCH_HUMANBioGRID19997087 23255053 details
PO5F1_HUMANETS2_HUMANBioGRID, HPRD11689681 details
PO5F1_HUMANCHIP_HUMANBioGRID29511337 details
PO5F1_HUMANEWS_HUMANHPRD15917470 details
PO5F1_HUMANNUCL_HUMANBioGRID, IntAct21048921 21151833 details
PO5F1_HUMANCTCF_HUMANDIP19536159 details
PO5F1_HUMANKDM6A_HUMANDIP22801502 details
PO5F1_HUMANMBD3_HUMANBioGRID, DIP24048479 26687479 details
PO5F1_HUMANHMGB1_HUMANBioGRID, HPRD11099378 21151833 details
PO5F1_HUMANHMGB2_HUMANBioGRID, HPRD11099378 details
PO5F1_HUMANSETB1_HUMANBioGRID19884257 details
PO5F1_HUMANSALL4_HUMANBioGRID19060217 26687479 details
PO5F1_HUMANRING2_HUMANBioGRID18339675 details
PO5F1_HUMANTIF1B_HUMANBioGRID20508149 details
PO5F1_HUMANZN281_HUMANBioGRID18757296 details
PO5F1_HUMANZN143_HUMANBioGRID18687992 details
PO5F1_HUMANPSD10_HUMANBioGRID22387393 details
PO5F1_HUMANXPC_HUMANBioGRID21962512 26687479 details
PO5F1_HUMANRD23B_HUMANBioGRID21962512 26687479 details
PO5F1_HUMANCETN2_HUMANBioGRID21962512 details
PO5F1_HUMANCTNB1_HUMANBioGRID23539445 32803659 details
PO5F1_HUMANBACH1_HUMANBioGRID30891497 details
PO5F1_HUMANFBXW7_HUMANBioGRID31534970 details
PO5F1_HUMANMYC_HUMANBioGRID31534970 details
PO5F1_HUMANCDN1B_HUMANBioGRID31534970 details
PO5F1_HUMANANDR_HUMANHPRD11096094 details
PO5F1_HUMANSOX8_HUMANHPRD16582099 details
PO5F1_HUMANSOX10_HUMANHPRD16582099 details