Entity Details

Primary name TIE2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ02763
EntryNameTIE2_HUMAN
FullNameAngiopoietin-1 receptor
TaxID9606
Evidenceevidence at protein level
Length1124
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesTEK

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001525 angiogenesis
GO:0001666 response to hypoxia
GO:0001934 positive regulation of protein phosphorylation
GO:0001935 endothelial cell proliferation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0001958 endochondral ossification
GO:0002040 sprouting angiogenesis
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005902 microvillus
GO:0005911 cell-cell junction
GO:0005925 focal adhesion
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007267 cell-cell signaling
GO:0007275 multicellular organism development
GO:0007507 heart development
GO:0009925 basal plasma membrane
GO:0009986 cell surface
GO:0010595 positive regulation of endothelial cell migration
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0016525 negative regulation of angiogenesis
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019838 growth factor binding
GO:0032878 regulation of establishment or maintenance of cell polarity
GO:0033674 positive regulation of kinase activity
GO:0034446 substrate adhesion-dependent cell spreading
GO:0034451 centriolar satellite
GO:0038023 signaling receptor activity
GO:0042802 identical protein binding
GO:0043066 negative regulation of apoptotic process
GO:0043114 regulation of vascular permeability
GO:0043235 receptor complex
GO:0043410 positive regulation of MAPK cascade
GO:0043434 response to peptide hormone
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0043627 response to estrogen
GO:0045121 membrane raft
GO:0045766 positive regulation of angiogenesis
GO:0046777 protein autophosphorylation
GO:0048014 Tie signaling pathway
GO:0050728 negative regulation of inflammatory response
GO:0050900 leukocyte migration
GO:0051591 response to cAMP
GO:0051894 positive regulation of focal adhesion assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0060216 definitive hemopoiesis
GO:0060347 heart trabecula formation
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0072012 glomerulus vasculature development
GO:1902533 positive regulation of intracellular signal transduction
GO:2000251 positive regulation of actin cytoskeleton reorganization
GO:2000351 regulation of endothelial cell apoptotic process
GO:2000352 negative regulation of endothelial cell apoptotic process

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cytoplasm
Secreted

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000742 EGF-like domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR003961 Fibronectin type IIIDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR018941 Tyrosine-protein kinase, receptor Tie-2, Ig-like domain 1, N-terminalDomainDomain
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
617272 OMIMGlaucoma 3, primary congenital, E (GLC3E)An autosomal dominant form of primary congenital glaucoma (PCG). PCG is characterized by marked increase of intraocular pressure at birth or early childhood, large ocular globes (buphthalmos) and corneal edema. It results from developmental defects of the trabecular meshwork and anterior chamber angle of the eye that prevent adequate drainage of aqueous humor. The disease is caused by variants affecting the gene represented in this entry.
600195 OMIMDominantly inherited venous malformations (VMCM)An error of vascular morphogenesis characterized by dilated, serpiginous channels. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00415 AmpicillinDrugbanksmall molecule
DB05294 VandetanibDrugbanksmall molecule
DB08221 N-{4-METHYL-3-[(3-PYRIMIDIN-4-YLPYRIDIN-2-YL)AMINO]PHENYL}-3-(TRIFLUOROMETHYL)BENZAMIDEDrugbanksmall molecule
DB08896 RegorafenibDrugbanksmall molecule
DB08901 PonatinibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB14840 RipretinibDrugbanksmall molecule

Interactions

37 interactions

InteractorPartnerSourcesPublicationsLink
TIE2_HUMANPTPRC_HUMANIntAct19167335 details
TIE2_HUMANPTPRK_HUMANIntAct19167335 details
TIE2_HUMANPTPRG_HUMANIntAct19167335 details
TIE2_HUMANPTPRB_HUMANHPRD, IntAct10557082 19167335 details
TIE2_HUMANPTPRJ_HUMANIntAct19167335 details
TIE2_HUMANPTPRO_HUMANIntAct19167335 details
TIE2_HUMANPTN12_HUMANIntAct19167335 details
TIE2_HUMANANGP2_HUMANBioGRID, DIP, HPRD, IntAct12427764 15893672 16732286 20708158 25237190 9204896 9723709 details
TIE2_HUMANANGP1_HUMANBioGRID, HPRD, IntAct12427764 20708158 8980223 8980224 9204896 9723709 details
TIE2_HUMANANGP4_HUMANBioGRID, HPRD, IntAct10051567 20708158 details
TIE2_HUMANSHC1_HUMANBioGRID, HPRD, MINT14665640 details
TIE2_HUMANNEMO_HUMANBioGRID, IntAct20098747 details
TIE2_HUMANSTYX_HUMANBioGRID, MINT28065597 details
TIE2_HUMANDUS18_HUMANBioGRID, MINT28065597 details
TIE2_HUMANPTPRR_HUMANBioGRID, MINT28065597 details
TIE2_HUMANILKAP_HUMANBioGRID, MINT28065597 details
TIE2_HUMANPTN11_HUMANBioGRID, HPRD, MINT10521483 28065597 details
TIE2_HUMANDOK2_HUMANBioGRID, HPRD11689432 9764820 details
TIE2_HUMANTNIP2_HUMANBioGRID, HPRD12609966 details
TIE2_HUMANA4_HUMANBioGRID21832049 details
TIE2_HUMANTIE2_HUMANBioGRID, HPRD10521483 11080633 26285778 9632797 details
TIE2_HUMANCAV1_HUMANBioGRID28760776 details
TIE2_HUMANSOCS1_HUMANBioGRID, HPRD10022833 29991678 details
TIE2_HUMANP85A_HUMANHPRD10521483 details
TIE2_HUMANGRB2_HUMANHPRD10521483 7478529 details
TIE2_HUMANGRB7_HUMANHPRD10521483 details
TIE2_HUMANGRB14_HUMANHPRD10521483 details
TIE2_HUMANCP1B1_HUMANIntAct28620713 details
TIE2_HUMANTIE1_HUMANBioGRID, HPRD10995770 details
TIE2_HUMANCBL_HUMANBioGRID19689429 details
TIE2_HUMANFAK1_HUMANBioGRID25792870 details
TIE2_HUMANAKT1_HUMANBioGRID25792870 details
TIE2_HUMANERBB2_HUMANBioGRID30898150 details
TIE2_HUMANANGL1_HUMANHPRD10051567 details
TIE2_HUMANSTA5A_HUMANHPRD14726409 details
TIE2_HUMANSTA5B_HUMANHPRD14726409 details
TIE2_HUMANDOK4_HUMANHPRD11470823 details