Entity Details

Primary name TIE2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ02763
EntryNameTIE2_HUMAN
FullNameAngiopoietin-1 receptor
TaxID9606
Evidenceevidence at protein level
Length1124
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesTEK

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001525 angiogenesis
GO:0001666 response to hypoxia
GO:0001934 positive regulation of protein phosphorylation
GO:0001935 endothelial cell proliferation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0001958 endochondral ossification
GO:0002040 sprouting angiogenesis
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005902 microvillus
GO:0005911 cell-cell junction
GO:0005925 focal adhesion
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007267 cell-cell signaling
GO:0007275 multicellular organism development
GO:0007507 heart development
GO:0009925 basal plasma membrane
GO:0009986 cell surface
GO:0010595 positive regulation of endothelial cell migration
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0016525 negative regulation of angiogenesis
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019838 growth factor binding
GO:0032878 regulation of establishment or maintenance of cell polarity
GO:0033674 positive regulation of kinase activity
GO:0034446 substrate adhesion-dependent cell spreading
GO:0034451 centriolar satellite
GO:0038023 signaling receptor activity
GO:0042802 identical protein binding
GO:0043066 negative regulation of apoptotic process
GO:0043114 regulation of vascular permeability
GO:0043235 receptor complex
GO:0043410 positive regulation of MAPK cascade
GO:0043434 response to peptide hormone
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0043627 response to estrogen
GO:0045121 membrane raft
GO:0045766 positive regulation of angiogenesis
GO:0046777 protein autophosphorylation
GO:0048014 Tie signaling pathway
GO:0050728 negative regulation of inflammatory response
GO:0050900 leukocyte migration
GO:0051591 response to cAMP
GO:0051894 positive regulation of focal adhesion assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0060216 definitive hemopoiesis
GO:0060347 heart trabecula formation
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0072012 glomerulus vasculature development
GO:1902533 positive regulation of intracellular signal transduction
GO:2000251 positive regulation of actin cytoskeleton reorganization
GO:2000351 regulation of endothelial cell apoptotic process
GO:2000352 negative regulation of endothelial cell apoptotic process

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cytoplasm
Secreted

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000742 EGF-like domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR003961 Fibronectin type IIIDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR018941 Tyrosine-protein kinase, receptor Tie-2, Ig-like domain 1, N-terminalDomainDomain
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00415 AmpicillinDrugbanksmall molecule
DB05294 VandetanibDrugbanksmall molecule
DB08221 N-{4-METHYL-3-[(3-PYRIMIDIN-4-YLPYRIDIN-2-YL)AMINO]PHENYL}-3-(TRIFLUOROMETHYL)BENZAMIDEDrugbanksmall molecule
DB08896 RegorafenibDrugbanksmall molecule
DB08901 PonatinibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB14840 RipretinibDrugbanksmall molecule

Interactions

37 interactions

InteractorPartnerSourcesPublicationsLink
TIE2_HUMANPTPRC_HUMANIntAct19167335 details
TIE2_HUMANPTPRK_HUMANIntAct19167335 details
TIE2_HUMANPTPRG_HUMANIntAct19167335 details
TIE2_HUMANPTPRB_HUMANHPRD, IntAct10557082 19167335 details
TIE2_HUMANPTPRJ_HUMANIntAct19167335 details
TIE2_HUMANPTPRO_HUMANIntAct19167335 details
TIE2_HUMANPTN12_HUMANIntAct19167335 details
TIE2_HUMANANGP2_HUMANBioGRID, DIP, HPRD, IntAct12427764 15893672 16732286 20708158 25237190 9204896 9723709 details
TIE2_HUMANANGP1_HUMANBioGRID, HPRD, IntAct12427764 20708158 8980223 8980224 9204896 9723709 details
TIE2_HUMANANGP4_HUMANBioGRID, HPRD, IntAct10051567 20708158 details
TIE2_HUMANSHC1_HUMANBioGRID, HPRD, MINT14665640 details
TIE2_HUMANNEMO_HUMANBioGRID, IntAct20098747 details
TIE2_HUMANSTYX_HUMANBioGRID, MINT28065597 details
TIE2_HUMANDUS18_HUMANBioGRID, MINT28065597 details
TIE2_HUMANPTPRR_HUMANBioGRID, MINT28065597 details
TIE2_HUMANILKAP_HUMANBioGRID, MINT28065597 details
TIE2_HUMANPTN11_HUMANBioGRID, HPRD, MINT10521483 28065597 details
TIE2_HUMANDOK2_HUMANBioGRID, HPRD11689432 9764820 details
TIE2_HUMANTNIP2_HUMANBioGRID, HPRD12609966 details
TIE2_HUMANA4_HUMANBioGRID21832049 details
TIE2_HUMANTIE2_HUMANBioGRID, HPRD10521483 11080633 26285778 9632797 details
TIE2_HUMANCAV1_HUMANBioGRID28760776 details
TIE2_HUMANSOCS1_HUMANBioGRID, HPRD10022833 29991678 details
TIE2_HUMANP85A_HUMANHPRD10521483 details
TIE2_HUMANGRB2_HUMANHPRD10521483 7478529 details
TIE2_HUMANGRB7_HUMANHPRD10521483 details
TIE2_HUMANGRB14_HUMANHPRD10521483 details
TIE2_HUMANCP1B1_HUMANIntAct28620713 details
TIE2_HUMANTIE1_HUMANBioGRID, HPRD10995770 details
TIE2_HUMANCBL_HUMANBioGRID19689429 details
TIE2_HUMANFAK1_HUMANBioGRID25792870 details
TIE2_HUMANAKT1_HUMANBioGRID25792870 details
TIE2_HUMANERBB2_HUMANBioGRID30898150 details
TIE2_HUMANANGL1_HUMANHPRD10051567 details
TIE2_HUMANSTA5A_HUMANHPRD14726409 details
TIE2_HUMANSTA5B_HUMANHPRD14726409 details
TIE2_HUMANDOK4_HUMANHPRD11470823 details