Entity Details

Primary name TOP2B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ02880
EntryNameTOP2B_HUMAN
FullNameDNA topoisomerase 2-beta
TaxID9606
Evidenceevidence at protein level
Length1626
SequenceStatuscomplete
DateCreated1993-07-01
DateModified2021-06-02

Ontological Relatives

GenesTOP2B

GO terms

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GOName
GO:0000712 resolution of meiotic recombination intermediates
GO:0000819 sister chromatid segregation
GO:0001764 neuron migration
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005080 protein kinase C binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0006265 DNA topological change
GO:0007409 axonogenesis
GO:0008022 protein C-terminus binding
GO:0019899 enzyme binding
GO:0030900 forebrain development
GO:0042826 histone deacetylase binding
GO:0045870 positive regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
GO:1990904 ribonucleoprotein complex

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001241 DNA topoisomerase, type IIAFamilyFamily
IPR002205 DNA topoisomerase, type IIA, subunit A/C-terminalDomainDomain
IPR003594 Histidine kinase/HSP90-like ATPaseDomainDomain
IPR006171 TOPRIM domainDomainDomain
IPR012542 DTHCTDomainDomain
IPR013506 DNA topoisomerase, type IIA, subunit B, domain 2DomainDomain
IPR013757 Type IIA DNA topoisomerase subunit A, alpha-helical domain superfamilyFamilyHomologous superfamily
IPR013758 DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-betaFamilyHomologous superfamily
IPR013759 DNA topoisomerase, type IIA, subunit B, C-terminalFamilyHomologous superfamily
IPR013760 DNA topoisomerase, type IIA-like domain superfamilyFamilyHomologous superfamily
IPR014721 Ribosomal protein S5 domain 2-type fold, subgroupFamilyHomologous superfamily
IPR018522 DNA topoisomerase, type IIA, conserved siteSiteConserved site
IPR020568 Ribosomal protein S5 domain 2-type foldFamilyHomologous superfamily
IPR028467 DNA topoisomerase II-betaFamilyFamily
IPR031660 C-terminal associated domain of TOPRIMDomainDomain
IPR034157 DNA topoisomerase 2, TOPRIM domainDomainDomain
IPR036890 Histidine kinase/HSP90-like ATPase superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00380 DexrazoxaneDrugbanksmall molecule
DB00694 DaunorubicinDrugbanksmall molecule
DB00773 EtoposideDrugbanksmall molecule
DB00970 DactinomycinDrugbanksmall molecule
DB04395 Phosphoaminophosphonic Acid-Adenylate EsterDrugbanksmall molecule
DB05022 AmonafideDrugbanksmall molecule
DB05488 Technetium Tc-99m ciprofloxacinDrugbanksmall molecule
DB06042 ZEN-012Drugbanksmall molecule
DB06362 BecatecarinDrugbanksmall molecule
DB06421 DeclopramideDrugbanksmall molecule
DB08651 3'-THIO-THYMIDINE-5'-PHOSPHATEDrugbanksmall molecule

Interactions

31 interactions

InteractorPartnerSourcesPublicationsLink
TOP2B_HUMANTOPB1_HUMANBioGRID, HPRD9461304 details
TOP2B_HUMANHDAC1_HUMANBioGRID, HPRD11062478 11136718 details
TOP2B_HUMANHDAC2_HUMANBioGRID11062478 details
TOP2B_HUMANTOP2A_HUMANBioGRID, HPRD22939629 8710863 details
TOP2B_HUMANP53_HUMANBioGRID, HPRD10666337 details
TOP2B_HUMANSUMO1_HUMANBioGRID, HPRD10862613 details
TOP2B_HUMANCD3E_HUMANBioGRID, HPRD8626450 details
TOP2B_HUMANCSK2B_HUMANBioGRID, HPRD11710515 details
TOP2B_HUMANRARA_HUMANBioGRID18212063 details
TOP2B_HUMANRBP2_HUMANBioGRID18394993 details
TOP2B_HUMANERG_HUMANBioGRID24591637 details
TOP2B_HUMANUBC9_HUMANBioGRID10862613 15561718 details
TOP2B_HUMANSUMO2_HUMANBioGRID19394292 details
TOP2B_HUMANLTOR5_HUMANBioGRID23241634 details
TOP2B_HUMANESR1_HUMANBioGRID, IntAct16794079 21182205 details
TOP2B_HUMANMTA2_HUMANBioGRID11062478 details
TOP2B_HUMANPARP1_HUMANBioGRID16794079 34079125 details
TOP2B_HUMANSRRM1_HUMANBioGRID16159877 details
TOP2B_HUMANPML_HUMANBioGRID18212063 details
TOP2B_HUMANCTCF_HUMANBioGRID19450526 details
TOP2B_HUMANRBX1_HUMANBioGRID30349055 32015321 details
TOP2B_HUMANBECN1_HUMANBioGRID28345663 details
TOP2B_HUMANPDCD4_HUMANBioGRID29395067 details
TOP2B_HUMANFBW1A_HUMANBioGRID32015321 details
TOP2B_HUMANATM_HUMANBioGRID32015321 details
TOP2B_HUMANKC1D_HUMANBioGRID32015321 details
TOP2B_HUMANISG15_HUMANBioGRID33024031 details
TOP2B_HUMANMK03_HUMANHPRD9155018 details
TOP2B_HUMANTOP2B_HUMANHPRD8626450 details
TOP2B_HUMANXPO1_HUMANHPRD12821127 details
TOP2B_HUMANXRCC5_HUMANHPRD12393188 details