Entity Details

Primary name UPAR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ03405
EntryNameUPAR_HUMAN
FullNameUrokinase plasminogen activator surface receptor
TaxID9606
Evidenceevidence at protein level
Length335
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesPLAUR

GO terms

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GOName
GO:0001934 positive regulation of protein phosphorylation
GO:0005102 signaling receptor binding
GO:0005576 extracellular region
GO:0005788 endoplasmic reticulum lumen
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005925 focal adhesion
GO:0006935 chemotaxis
GO:0007165 signal transduction
GO:0007596 blood coagulation
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0019898 extrinsic component of membrane
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0030162 regulation of proteolysis
GO:0030377 urokinase plasminogen activator receptor activity
GO:0031225 anchored component of membrane
GO:0034112 positive regulation of homotypic cell-cell adhesion
GO:0035579 specific granule membrane
GO:0038023 signaling receptor activity
GO:0042730 fibrinolysis
GO:0042995 cell projection
GO:0043066 negative regulation of apoptotic process
GO:0043312 neutrophil degranulation
GO:0043388 positive regulation of DNA binding
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
GO:2001268 negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Secreted

Domains

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DomainNameCategoryType
IPR016054 Ly-6 antigen/uPA receptor-likeDomainDomain
IPR018363 CD59 antigen, conserved siteSiteConserved site
IPR033084 Urokinase plasminogen activator surface receptorFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB00009 AlteplaseDrugbankbiotech
DB00013 UrokinaseDrugbankbiotech
DB00031 TenecteplaseDrugbankbiotech
DB05476 WX-UK1Drugbanksmall molecule
DB06245 LanoteplaseDrugbankbiotech