Entity Details

Primary name EXOS9_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ06265
EntryNameEXOS9_HUMAN
FullNameExosome complex component RRP45
TaxID9606
Evidenceevidence at protein level
Length439
SequenceStatuscomplete
DateCreated2001-06-01
DateModified2021-06-02

Ontological Relatives

GenesEXOSC9

GO terms

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GOName
GO:0000175 3'-5'-exoribonuclease activity
GO:0000176 nuclear exosome (RNase complex)
GO:0000177 cytoplasmic exosome (RNase complex)
GO:0000178 exosome (RNase complex)
GO:0000228 nuclear chromosome
GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000956 nuclear-transcribed mRNA catabolic process
GO:0003723 RNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006364 rRNA processing
GO:0006955 immune response
GO:0016075 rRNA catabolic process
GO:0030307 positive regulation of cell growth
GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
GO:0034473 U1 snRNA 3'-end processing
GO:0034475 U4 snRNA 3'-end processing
GO:0034476 U5 snRNA 3'-end processing
GO:0035925 mRNA 3'-UTR AU-rich region binding
GO:0043488 regulation of mRNA stability
GO:0043928 exonucleolytic catabolism of deadenylated mRNA
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0070062 extracellular exosome
GO:0071028 nuclear mRNA surveillance
GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process
GO:0071038 nuclear polyadenylation-dependent tRNA catabolic process
GO:0071042 nuclear polyadenylation-dependent mRNA catabolic process

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001247 Exoribonuclease, phosphorolytic domain 1DomainDomain
IPR015847 Exoribonuclease, phosphorolytic domain 2DomainDomain
IPR020568 Ribosomal protein S5 domain 2-type foldFamilyHomologous superfamily
IPR027408 PNPase/RNase PH domain superfamilyFamilyHomologous superfamily
IPR033100 Exosome complex component RRP45FamilyFamily
IPR036345 Exoribonuclease, PH domain 2 superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
618065 OMIMPontocerebellar hypoplasia 1D (PCH1D)An autosomal recessive neurologic disorder with onset at birth or in infancy, and characterized by progressive axonal motor neuronopathy, severe generalized hypotonia, respiratory insufficiency, and cerebellar atrophy. Death in childhood may occur. The disease is caused by variants affecting the gene represented in this entry.

Interactions

31 interactions

InteractorPartnerSourcesPublicationsLink
EXOS9_HUMANDX39B_HUMANHPRD, IntAct14667819 details
EXOS9_HUMANEXOS4_HUMANBioGRID, HPRD, IntAct, MINT, UniProt11719186 12788944 15231747 20531386 22939629 24981860 26344197 26496610 27173435 30021884 unassigned1312 details
EXOS9_HUMANUBC9_HUMANBioGRID, IntAct19549727 20936779 details
EXOS9_HUMANEXOS3_HUMANBioGRID, HPRD, IntAct, MINT12788944 20531389 22939629 24981860 26186194 26344197 26496610 28514442 details
EXOS9_HUMANRRP44_HUMANBioGRID, HPRD, MINT11719186 12788944 20531386 26344197 details
EXOS9_HUMANEXOS2_HUMANBioGRID, HPRD, IntAct, UniProt11719186 12788944 17412707 17545563 22939629 24981860 26344197 26496610 27173435 unassigned1312 details
EXOS9_HUMANEXOS7_HUMANBioGRID, HPRD, IntAct, UniProt11719186 12788944 24981860 26186194 26344197 26496610 27173435 28514442 unassigned1312 details
EXOS9_HUMANCSK21_HUMANBioGRID, IntAct22113938 details
EXOS9_HUMANZDH17_HUMANBioGRID, IntAct24705354 details
EXOS9_HUMANSETX_HUMANUniProt24244371 details
EXOS9_HUMANEXOS1_HUMANBioGRID, DIP, HPRD, IntAct11719186 12419256 12788944 24981860 25043052 26344197 26496610 28514442 details
EXOS9_HUMANEXOS5_HUMANBioGRID, HPRD, IntAct, MINT11719186 12788944 22939629 24981860 26344197 26496610 details
EXOS9_HUMANEXOS8_HUMANBioGRID, HPRD, IntAct11719186 12788944 24981860 26186194 26496610 28514442 details
EXOS9_HUMANEXOS6_HUMANBioGRID, HPRD, IntAct11719186 12788944 24981860 26344197 26496610 details
EXOS9_HUMANHBS1L_HUMANBioGRID, IntAct24981860 26496610 27345150 details
EXOS9_HUMANCHM4B_HUMANBioGRID, HPRD, IntAct16730941 details
EXOS9_HUMANCHM1A_HUMANIntAct16730941 details
EXOS9_HUMANCHMP5_HUMANIntAct16730941 details
EXOS9_HUMANSUMO2_HUMANBioGRID19394292 32786267 details
EXOS9_HUMANMPH6_HUMANBioGRID24981860 26344197 26496610 28877463 details
EXOS9_HUMANEXOS9_HUMANHPRD14667819 details
EXOS9_HUMANDX39A_HUMANHPRD14667819 details
EXOS9_HUMANLUM_HUMANBioGRID, IntAct27173435 unassigned1312 details
EXOS9_HUMANLRC47_HUMANBioGRID, IntAct27173435 unassigned1312 details
EXOS9_HUMANSLIT2_HUMANBioGRID, IntAct27173435 unassigned1312 details
EXOS9_HUMANRSRC1_HUMANBioGRID, IntAct27173435 unassigned1312 details
EXOS9_HUMANAICDA_HUMANBioGRID21255825 details
EXOS9_HUMAN3MG_HUMANBioGRID23537643 details
EXOS9_HUMANYBOX1_HUMANBioGRID26343856 details
EXOS9_HUMANMTREX_HUMANBioGRID, HPRD11719186 24981860 details
EXOS9_HUMANPALS2_HUMANHPRD11719186 details