Entity Details

Primary name SOX4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ06945
EntryNameSOX4_HUMAN
FullNameTranscription factor SOX-4
TaxID9606
Evidenceevidence at protein level
Length474
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesSOX4

GO terms

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GOName
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001501 skeletal system development
GO:0001841 neural tube formation
GO:0002328 pro-B cell differentiation
GO:0003183 mitral valve morphogenesis
GO:0003211 cardiac ventricle formation
GO:0003215 cardiac right ventricle morphogenesis
GO:0003289 atrial septum primum morphogenesis
GO:0003357 noradrenergic neuron differentiation
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0006355 regulation of transcription, DNA-templated
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007507 heart development
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0009653 anatomical structure morphogenesis
GO:0014009 glial cell proliferation
GO:0021510 spinal cord development
GO:0021522 spinal cord motor neuron differentiation
GO:0021782 glial cell development
GO:0030154 cell differentiation
GO:0030217 T cell differentiation
GO:0031018 endocrine pancreas development
GO:0031397 negative regulation of protein ubiquitination
GO:0031647 regulation of protein stability
GO:0032024 positive regulation of insulin secretion
GO:0035019 somatic stem cell population maintenance
GO:0035198 miRNA binding
GO:0035910 ascending aorta morphogenesis
GO:0042593 glucose homeostasis
GO:0042769 DNA damage response, detection of DNA damage
GO:0043065 positive regulation of apoptotic process
GO:0045588 positive regulation of gamma-delta T cell differentiation
GO:0045727 positive regulation of translation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048485 sympathetic nervous system development
GO:0050821 protein stabilization
GO:0060174 limb bud formation
GO:0060412 ventricular septum morphogenesis
GO:0060548 negative regulation of cell death
GO:0060563 neuroepithelial cell differentiation
GO:0060993 kidney morphogenesis
GO:0061484 hematopoietic stem cell homeostasis
GO:0071333 cellular response to glucose stimulus
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000761 positive regulation of N-terminal peptidyl-lysine acetylation

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR009071 High mobility group box domainDomainDomain
IPR017386 Transcription factor SOX-12/11/4FamilyFamily
IPR036910 High mobility group box domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

49 interactions

InteractorPartnerSourcesPublicationsLink
SOX4_HUMANP53_HUMANBioGRID, DIP19234109 details
SOX4_HUMANSDCB1_HUMANBioGRID, HPRD11498591 details
SOX4_HUMANUBC9_HUMANBioGRID, HPRD16631117 details
SOX4_HUMANTNNI3_HUMANBioGRID25969425 details
SOX4_HUMANSCNNG_HUMANBioGRID25969425 details
SOX4_HUMANMINP1_HUMANBioGRID25969425 details
SOX4_HUMANIGF1_HUMANBioGRID25969425 details
SOX4_HUMANPLD3_HUMANBioGRID25969425 details
SOX4_HUMANCAN15_HUMANBioGRID25969425 details
SOX4_HUMANFOXH1_HUMANBioGRID25969425 details
SOX4_HUMANRGSL_HUMANBioGRID25969425 details
SOX4_HUMANLMNB2_HUMANBioGRID25969425 details
SOX4_HUMANCTR9_HUMANBioGRID25969425 details
SOX4_HUMANITIH1_HUMANBioGRID25969425 details
SOX4_HUMANAPOC3_HUMANBioGRID25969425 details
SOX4_HUMANEDF1_HUMANBioGRID25969425 details
SOX4_HUMANNANGN_HUMANBioGRID25969425 details
SOX4_HUMANMNT_HUMANBioGRID25969425 details
SOX4_HUMANPLXB1_HUMANBioGRID25969425 details
SOX4_HUMANRP1L1_HUMANBioGRID25969425 details
SOX4_HUMANBAF_HUMANBioGRID25969425 details
SOX4_HUMANRHOU_HUMANBioGRID26598620 details
SOX4_HUMANAURKA_HUMANBioGRID28205554 details
SOX4_HUMANCDN2A_HUMANBioGRID28205554 details
SOX4_HUMANARF_HUMANBioGRID28205554 details
SOX4_HUMANDACH1_HUMANBioGRID28205554 details
SOX4_HUMANNSD3_HUMANBioGRID28205554 details
SOX4_HUMANAKT1_HUMANBioGRID28205554 details
SOX4_HUMANFZR1_HUMANBioGRID28205554 details
SOX4_HUMANRASK_HUMANBioGRID28205554 details
SOX4_HUMANMYC_HUMANBioGRID28205554 details
SOX4_HUMANNF1_HUMANBioGRID28205554 details
SOX4_HUMANMERL_HUMANBioGRID28205554 details
SOX4_HUMANSMCA4_HUMANBioGRID28205554 details
SOX4_HUMANSTK11_HUMANBioGRID28205554 details
SOX4_HUMANTERT_HUMANBioGRID28205554 details
SOX4_HUMANTSC1_HUMANBioGRID28205554 details
SOX4_HUMANWT1_HUMANBioGRID28205554 details
SOX4_HUMANGATA3_HUMANInnateDB22751141 details
SOX4_HUMANEP15R_HUMANBioGRID, IntAct27173435 unassigned1312 details
SOX4_HUMANUBP15_HUMANBioGRID, IntAct27173435 unassigned1312 details
SOX4_HUMANMCM2_HUMANBioGRID, IntAct27173435 unassigned1312 details
SOX4_HUMANMCM4_HUMANBioGRID, IntAct27173435 unassigned1312 details
SOX4_HUMANJIP4_HUMANBioGRID, IntAct27173435 unassigned1312 details
SOX4_HUMANMCM6_HUMANBioGRID, IntAct27173435 unassigned1312 details
SOX4_HUMANEP300_HUMANBioGRID, DIP19234109 details
SOX4_HUMANCBP_HUMANDIP19234109 details
SOX4_HUMANMDM2_HUMANBioGRID19234109 details
SOX4_HUMANTAF5_HUMANBioGRID23884650 details