Entity Details

Primary name KCNA1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ09470
EntryNameKCNA1_HUMAN
FullNamePotassium voltage-gated channel subfamily A member 1
TaxID9606
Evidenceevidence at protein level
Length495
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesKCNA1

GO terms

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GOName
GO:0001964 startle response
GO:0005249 voltage-gated potassium channel activity
GO:0005251 delayed rectifier potassium channel activity
GO:0005267 potassium channel activity
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006813 potassium ion transport
GO:0006937 regulation of muscle contraction
GO:0007268 chemical synaptic transmission
GO:0007405 neuroblast proliferation
GO:0008076 voltage-gated potassium channel complex
GO:0009986 cell surface
GO:0010644 cell communication by electrical coupling
GO:0010960 magnesium ion homeostasis
GO:0015079 potassium ion transmembrane transporter activity
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0019228 neuronal action potential
GO:0021766 hippocampus development
GO:0023041 neuronal signal transduction
GO:0030054 cell junction
GO:0030425 dendrite
GO:0031410 cytoplasmic vesicle
GO:0033270 paranode region of axon
GO:0034613 cellular protein localization
GO:0042391 regulation of membrane potential
GO:0042734 presynaptic membrane
GO:0043025 neuronal cell body
GO:0043204 perikaryon
GO:0043679 axon terminus
GO:0044224 juxtaparanode region of axon
GO:0044305 calyx of Held
GO:0045202 synapse
GO:0050905 neuromuscular process
GO:0050966 detection of mechanical stimulus involved in sensory perception of pain
GO:0050976 detection of mechanical stimulus involved in sensory perception of touch
GO:0051260 protein homooligomerization
GO:0071286 cellular response to magnesium ion
GO:0071805 potassium ion transmembrane transport
GO:0097718 disordered domain specific binding
GO:0098978 glutamatergic synapse
GO:0099055 integral component of postsynaptic membrane
GO:0099056 integral component of presynaptic membrane
GO:0099508 voltage-gated ion channel activity involved in regulation of presynaptic membrane potential
GO:1903818 positive regulation of voltage-gated potassium channel activity
GO:1905030 voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cell projection
Cytoplasmic vesicle
Endoplasmic reticulum
Membrane
Perikaryon

Domains

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DomainNameCategoryType
IPR000210 BTB/POZ domainDomainDomain
IPR003131 Potassium channel tetramerisation-type BTB domainDomainDomain
IPR003968 Potassium channel, voltage dependent, KvFamilyFamily
IPR003972 Potassium channel, voltage dependent, Kv1FamilyFamily
IPR004048 Potassium channel, voltage dependent, Kv1.1FamilyFamily
IPR005821 Ion transport domainDomainDomain
IPR011333 SKP1/BTB/POZ domain superfamilyFamilyHomologous superfamily
IPR027359 Voltage-dependent channel domain superfamilyFamilyHomologous superfamily
IPR028325 Voltage-gated potassium channelFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB00228 EnfluraneDrugbanksmall molecule
DB00321 AmitriptylineDrugbanksmall molecule
DB00753 IsofluraneDrugbanksmall molecule
DB01028 MethoxyfluraneDrugbanksmall molecule
DB01069 PromethazineDrugbanksmall molecule
DB01110 MiconazoleDrugbanksmall molecule
DB01189 DesfluraneDrugbanksmall molecule
DB06637 DalfampridineDrugbanksmall molecule
DB08837 TetraethylammoniumDrugbanksmall molecule
DB11640 AmifampridineDrugbanksmall molecule