Entity Details

Primary name CDK4
Entity type gene
Source Source Link

Details

PrimaryID1019
RefseqGeneNG_007484
SymbolCDK4
Namecyclin dependent kinase 4
Chromosome12
Location12q14.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-05
ModificationDate2021-06-13

Ontological Relatives

UniProt IDsCDK4_HUMAN

GO terms

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GOName
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000307 cyclin-dependent protein kinase holoenzyme complex
GO:0000785 chromatin
GO:0002088 lens development in camera-type eye
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0005923 bicellular tight junction
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007623 circadian rhythm
GO:0008284 positive regulation of cell population proliferation
GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity
GO:0009636 response to toxic substance
GO:0010288 response to lead ion
GO:0010468 regulation of gene expression
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
GO:0016592 mediator complex
GO:0030332 cyclin binding
GO:0030851 granulocyte differentiation
GO:0031100 animal organ regeneration
GO:0031965 nuclear membrane
GO:0032869 cellular response to insulin stimulus
GO:0033574 response to testosterone
GO:0040014 regulation of multicellular organism growth
GO:0042493 response to drug
GO:0043065 positive regulation of apoptotic process
GO:0044877 protein-containing complex binding
GO:0045727 positive regulation of translation
GO:0045787 positive regulation of cell cycle
GO:0045793 positive regulation of cell size
GO:0046626 regulation of insulin receptor signaling pathway
GO:0046890 regulation of lipid biosynthetic process
GO:0048146 positive regulation of fibroblast proliferation
GO:0048471 perinuclear region of cytoplasm
GO:0050994 regulation of lipid catabolic process
GO:0051301 cell division
GO:0051726 regulation of cell cycle
GO:0055093 response to hyperoxia
GO:0060260 regulation of transcription initiation from RNA polymerase II promoter
GO:0060612 adipose tissue development
GO:0071222 cellular response to lipopolysaccharide
GO:0071353 cellular response to interleukin-4
GO:0097129 cyclin D2-CDK4 complex
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1904628 cellular response to phorbol 13-acetate 12-myristate
GO:1904637 cellular response to ionomycin
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle

Diseases

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Interactions

256 interactions

InteractorPartnerSourcesPublicationsLink
CDK4CDC37BioGRID, DIP, HPRD, IntAct, MINT, Molecular Connections11867521 17353931 21675959 21871133 24189400 24292678 24981860 25036637 26186194 27339980 28514442 8666233 8703009 9150368 details
CDK4CCND1BioGRID, DIP, HPRD, I2D, IntAct10022865 10580009 10908655 11160398 11360184 11463845 12036906 12519773 15232106 16431923 16985050 17205132 17420273 18537972 19075005 19237565 19470470 19767775 20837141 21242975 21306487 21654808 23007395 23707388 23718855 24218572 24292678 24855949 25241761 25416956 25502805 25910212 26203195 27107012 27130439 28514442 29142209 31217276 31515488 33854235 7568034 8259215 8662825 8756624 8867812 8978686 9106657 9150368 9178893 9228064 9372967 9837900 details
CDK4CDKN1ABioGRID, HPRD, IntAct, MINT10022865 11463845 12383116 15169570 15232106 15695403 16962592 17556661 18850315 20102411 23007395 23443559 28514442 30833792 8622677 8756624 9106657 9464540 9632134 9658399 details
CDK4CDKN1BBioGRID, DIP, HPRD, IntAct, MINT10022865 10198259 10908655 11360184 11940657 15695403 16326706 16782892 17053782 18285702 18615582 18850315 19470470 20837141 21439954 23602568 23707388 25241761 26186194 28514442 8978686 9106657 9311993 9464540 9632134 9658399 details
CDK4CAPNS1BioGRID, HPRD, IntAct16169070 details
CDK4VTA1BioGRID, HPRD, IntAct16189514 details
CDK4CDKN2CBioGRID, HPRD, IntAct, MINT10022865 11900540 17353931 21988832 23455922 23602568 24981860 25416956 25910212 26186194 27107012 28205554 28514442 31515488 32296183 8001816 details
CDK4SHOX2BioGRID, IntAct22094256 details
CDK4ZNF335BioGRID, IntAct22094256 details
CDK4WDR33BioGRID, IntAct22094256 details
CDK4CEBPABioGRID, HPRD11684017 11867521 15107404 details
CDK4RB1BioGRID, HPRD10198259 10202152 10486249 11254678 11287611 11306463 11900540 11971966 12190313 12509456 12519773 12676926 12949733 15003538 15147269 15169570 15241418 15695403 15922743 15998794 16205633 16326706 16878158 16962592 16985050 17015477 17053782 17873913 19225156 19556892 19767775 22094256 23543736 24292678 30833542 8449399 8626527 8647086 8756624 8867812 9003781 9139732 9190208 9199321 9315635 9464540 details
CDK4BECN1BioGRID28205554 details
CDK4TERTBioGRID28205554 details
CDK4ERBB2BioGRID28205554 details
CDK4GRM1BioGRID28205554 details
CDK4CDKN2ABioGRID, DIP, HPRD, IntAct, MINT10022865 10491434 10580009 10585280 10719365 11556834 11900540 12529334 15065884 15232106 17353931 17517622 17881001 17909018 17955473 23455922 23602568 24855949 24981860 26186194 26496610 28042499 28205554 28218424 28514442 8259215 8805225 9228064 9529249 details
CDK4CCND3BioGRID, DIP, HPRD, IntAct, MINT, UniProt10342870 11360184 11896535 14641107 15232106 16189514 16782892 16985050 19237555 21516116 21988832 23880157 25416956 25910212 26186194 26496610 27107012 28514442 30217970 31515488 32296183 33854235 9106657 9716181 details
CDK4CDC7BioGRID, HPRD, IntAct15232106 details
CDK4CDKN2BBioGRID, HPRD, IntAct, MINT10022865 16169070 16189514 19447967 21900206 23455922 23602568 24981860 25910212 26186194 26496610 28205554 28514442 31515488 32296183 7478582 9111314 9163429 details
CDK4BAG6BioGRID, HPRD, IntAct16169070 17353931 details
CDK4CDKN2DBioGRID, HPRD, IntAct, MINT10022865 16189514 23602568 23718855 24981860 25416956 25910212 26186194 27107012 28514442 31515488 32296183 7739548 details
CDK4MYCBioGRID, IntAct21988832 22094256 24951594 28205554 details
CDK4SKP1BioGRID, IntAct21988832 details
CDK4DDAH2BioGRID, MINT21900206 details
CDK4TK1BioGRID, MINT21900206 details
CDK4OTX2BioGRID, IntAct22094256 details
CDK4GLI1BioGRID, IntAct22094256 26603838 details
CDK4HSP90AA1BioGRID, IntAct11867521 16611982 22315411 22939624 23455922 24292678 26186194 26804907 28514442 28537252 details
CDK4SMAD3BioGRID, HPRD, IntAct15241418 25241761 details
CDK4HOOK1BioGRID, IntAct25416956 25910212 31515488 32296183 details
CDK4CDK7DIP16327805 details
CDK4SPOPBioGRID29160310 details
CDK4MAPK14BioGRID28205554 details
CDK4ZNF655BioGRID, HPRD, IntAct15558030 32296183 details
CDK4CCND2BioGRID, HPRD, IntAct10022865 11360184 11896535 11971966 15169570 17873913 25910212 26186194 27107012 28205554 28514442 30217970 31515488 32296183 9178893 details
CDK4LUC7L2BioGRID, MINT21900206 details
CDK4ANKRD12BioGRID, IntAct22094256 details
CDK4CNOT7BioGRID, HPRD10602502 30217970 details
CDK4BRCA1BioGRID, HPRD12509456 17334399 9244350 details
CDK4PIAS1BioGRID30217970 details
CDK4STUB1BioGRID29326975 details
CDK4SENP3BioGRID, IntAct22094256 details
CDK4MYOD1BioGRID, HPRD10022835 10601020 details
CDK4MARCKSBioGRID10359664 details
CDK4CD44BioGRID28205554 details
CDK4MCM2BioGRID, HPRD, IntAct15232106 details
CDK4DUSP9BioGRID, IntAct21988832 details
CDK4QARS1BioGRID, MINT21900206 details
CDK4RBL2BioGRID, IntAct22094256 details
CDK4IKZF3BioGRID, IntAct32296183 details
CDK4NCOA2BioGRID, HPRD12130539 details
CDK4H1-3BioGRID18850315 details
CDK4CCNE1BioGRID28205554 9716181 details
CDK4PKMBioGRID, MINT21900206 details
CDK4ZNF101BioGRID, IntAct22094256 details
CDK4CDK4BioGRID28205554 details
CDK4SETDB1BioGRID, HPRD, IntAct, MINT16169070 21900206 details
CDK4RBL1BioGRID, HPRD, IntAct12006580 22094256 details
CDK4OGDHLBioGRID, IntAct32296183 details
CDK4H1-1BioGRID10447003 11132966 16431923 16878158 9464540 details
CDK4PSMD10BioGRID, HPRD11779854 11900540 17881001 details
CDK4AKT1BioGRID28205554 details
CDK4MAP2K5BioGRID28205554 details
CDK4TSC1BioGRID28205554 details
CDK4KDELR2BioGRID28205554 details
CDK4PGDBioGRID, IntAct21988832 details
CDK4DAZAP2BioGRID, MINT21900206 details
CDK4LNX2BioGRID, IntAct27107012 details
CDK4INCA1BioGRID, IntAct32296183 details
CDK4FZR1BioGRID28205554 details
CDK4AGAP2BioGRID30833542 details
CDK4TRMT2ABioGRID, MINT21900206 details
CDK4NF2BioGRID28205554 details
CDK4FBXO8BioGRID32796813 details
CDK4CIB1BioGRID, IntAct21988832 details
CDK4BCL11ABioGRID, IntAct22094256 details
CDK4MZF1BioGRID, IntAct22094256 details
CDK4CDK6BioGRID, IntAct23455922 28205554 details
CDK4TSPYL2BioGRID11395479 details
CDK4MAP2K3BioGRID28205554 details
CDK4IL15RABioGRID, IntAct21988832 details
CDK4FOXM1BioGRID, IntAct22094256 details
CDK4UHRF2BioGRID, UniProt21952639 details
CDK4RPL34BioGRID10049762 details
CDK4UBE3ABioGRID29263404 details
CDK4EPHA2BioGRID28205554 details
CDK4STK11BioGRID28205554 details
CDK4MAP3K5BioGRID28205554 details
CDK4HMGXB3BioGRID, MINT21900206 details
CDK4SERTAD1BioGRID, HPRD10580009 15065884 details
CDK4H1-0BioGRID12383116 details
CDK4FGFR4BioGRID28205554 details
CDK4GLIS2BioGRID28205554 details
CDK4NOL12HPRD, IntAct16169070 details
CDK4PPP1CABioGRID, IntAct17274640 22939629 details
CDK4PPP1CCIntAct17274640 details
CDK4MAPRE2BioGRID, IntAct21988832 details
CDK4APOBEC3BIntAct31217276 details
CDK4APLP1BioGRID, MINT21900206 details
CDK4SMAD2BioGRID, HPRD15241418 details
CDK4ATP5F1BBioGRID, MINT21900206 details
CDK4CDC6BioGRID, IntAct22094256 details
CDK4ARAFBioGRID28205554 details
CDK4ARNTBioGRID28205554 details
CDK4CDKN1CBioGRID, HPRD, IntAct10713702 9106657 details
CDK4ANXA7BioGRID, MINT21900206 details
CDK4SNCABioGRID, MINT21900206 details
CDK4ZNF219BioGRID, IntAct22094256 details
CDK4USP17L2BioGRID28067227 details
CDK4PDGFRABioGRID28205554 details
CDK4TP53BioGRID28205554 28218424 details
CDK4TEAD2BioGRID28205554 details
CDK4MDM4BioGRID28205554 details
CDK4APPBioGRID21832049 details
CDK4EIF4EBP2BioGRID30217970 details
CDK4SLBPBioGRID, IntAct22094256 details
CDK4RAF1BioGRID28205554 details
CDK4ZBTB16BioGRID, MINT21900206 details
CDK4YBX3BioGRID10100871 details
CDK4IGF1RBioGRID28205554 details
CDK4HGFBioGRID28205554 details
CDK4HIF1ABioGRID28205554 details
CDK4POLD1BioGRID9545286 details
CDK4LATS2BioGRID28205554 details
CDK4METBioGRID28205554 details
CDK4RASSF1BioGRID28205554 details
CDK4UBTFBioGRID10202152 details
CDK4ARID4ABioGRID21148318 details
CDK4CAMK1BioGRID23707388 details
CDK4CNTN2BioGRID12779347 details
CDK4USP51BioGRID32296027 details
CDK4GATA2BioGRID17255359 details
CDK4TGFBR1HPRD15761153 details
CDK4CDK5R1BioGRID22654103 details
CDK4HSP90AB1BioGRID, IntAct22939624 23455922 26186194 28514442 details
CDK4KAT2ADIP24870244 details
CDK4E2F4BioGRID, IntAct27173435 unassigned1312 details
CDK4DNAJC9BioGRID, IntAct27173435 unassigned1312 details
CDK4PSMD9BioGRID12684681 details
CDK4PAQR4BioGRID28992327 details
CDK4RELABioGRID25331947 details
CDK4FNIP1BioGRID27353360 details
CDK4MCCIntAct17353931 details
CDK4PCNABioGRID11254741 8101826 8259215 details
CDK4PTMABioGRID, HPRD11310559 details
CDK4FBXL6BioGRID31181401 details
CDK4ORC3HPRD15232106 details
CDK4TSC2IntAct26977878 details
CDK4CCNA2BioGRID24302728 9716181 details
CDK4PRKAA1BioGRID30833542 details
CDK4BIRC5BioGRID, HPRD10713676 details
CDK4NUP155IntAct17353931 details
CDK4RFC1BioGRID, HPRD10353443 details
CDK4UCHL1BioGRID23543736 details
CDK4PRMT5BioGRID20951943 details
CDK4BMPR1BHPRD15761153 details
CDK4ASPMBioGRID, IntAct17353931 26496610 details
CDK4CSTF3IntAct17353931 details
CDK4RPA2BioGRID20679368 details
CDK4CDC45HPRD15232106 details
CDK4COPB2IntAct17353931 details
CDK4SKP2BioGRID28992327 details
CDK4FNIP2BioGRID27353360 details
CDK4MMS19IntAct17353931 details
CDK4HSPA8BioGRID18537972 details
CDK4PSMA6BioGRID22158041 details
CDK4FBXO4BioGRID28992327 details
CDK4RFC4HPRD10353443 details
CDK4RPA1BioGRID20679368 details
CDK4PRKAR1AHPRD16582606 details
CDK4SP1BioGRID18769160 details
CDK4MTFP1IntAct17353931 details
CDK4CDT1BioGRID15004027 details
CDK4EGLN2BioGRID26644182 details
CDK4IFI27HPRD9837900 details
CDK4UBXN1BioGRID, IntAct17353931 details
CDK4ARRB2BioGRID, IntAct17620599 details
CDK4CUL3BioGRID, IntAct21145461 details
CDK4GFERBioGRID, IntAct26186194 28514442 details
CDK4MRPS34BioGRID, MINT24981860 details
CDK4SAP25BioGRID16449650 details
CDK4NTRK1BioGRID25921289 details
CDK4HEXIM1BioGRID29845934 details
CDK4PHBBioGRID27025967 details
CDK4CDK13BioGRID, IntAct23602568 26496610 details
CDK4CUL1BioGRID, IntAct21145461 details
CDK4CUL4BBioGRID, IntAct21145461 details
CDK4SORBS1BioGRID, IntAct26496610 details
CDK4ZC3H14BioGRID, IntAct26496610 details
CDK4VTNBioGRID, IntAct28514442 details
CDK4RCAN3BioGRID, IntAct26186194 28514442 details
CDK4OGFRL1BioGRID, IntAct26186194 28514442 details
CDK4PPP2R1BBioGRID, HPRD, IntAct17540176 details
CDK4IRF8BioGRID, IntAct21903422 details
CDK4SMTNBioGRID, IntAct26496610 details
CDK4IKBKGBioGRID, IntAct30561431 details
CDK4SLC25A1BioGRID, MINT24981860 details
CDK4TUBBBioGRID34079125 details
CDK4SMC3BioGRID, IntAct17353931 details
CDK4FKBP5BioGRID, IntAct25036637 26186194 28514442 details
CDK4HRASBioGRID30194290 details
CDK4SMC1ABioGRID, IntAct17353931 details
CDK4PPP2R1ABioGRID, IntAct17540176 details
CDK4JAK3BioGRID, IntAct26186194 28514442 details
CDK4LYNBioGRID, IntAct17353931 details
CDK4COPS6BioGRID, IntAct21145461 details
CDK4CEP135BioGRID, IntAct26638075 details
CDK4TRIM28BioGRID29955894 details
CDK4TRAP1BioGRID, IntAct23455922 details
CDK4NUP133BioGRID, IntAct26496610 details
CDK4AK2BioGRID, MINT24981860 details
CDK4ACTR3BBioGRID, IntAct17353931 details
CDK4IQGAP1BioGRID, IntAct26496610 details
CDK4OGFRBioGRID, IntAct26186194 28514442 details
CDK4EGLN3BioGRID26972000 details
CDK4CCAR2BioGRID32152128 details
CDK4GEMIN4BioGRID, IntAct17353931 details
CDK4PGRMC1BioGRID31067491 details
CDK4DBNLBioGRID, IntAct17353931 details
CDK4KSR1IntAct27086506 details
CDK4KLHL32BioGRID23718855 details
CDK4BIRC3BioGRID30948266 details
CDK4TMEM126ABioGRID, IntAct26496610 details
CDK4GUSBBioGRID, IntAct26186194 28514442 details
CDK4MTMR8BioGRID27432908 details
CDK4CLUAP1BioGRID29615496 details
CDK4MAPK1BioGRID, MINT24981860 details
CDK4ZNFX1BioGRID, IntAct26496610 details
CDK4LARP7BioGRID29845934 details
CDK4SOX2BioGRID28794006 details
CDK4PLK1BioGRID31730000 details
CDK4PTPN1BioGRID27432908 details
CDK4WDR77BioGRID, IntAct20951943 details
CDK4MTMR14BioGRID27432908 details
CDK4ANKRA2BioGRID, UniProt25752541 details
CDK4LMBR1LBioGRID31073040 details
CDK4COPS5BioGRID, IntAct21145461 details
CDK4LIMK2BioGRID, IntAct25852190 details
CDK4LRRK2IntAct31046837 details
CDK4TARDBPBioGRID20020773 details
CDK4VSIG8BioGRID26186194 details
CDK4CUL4ABioGRID30945288 details
CDK4UFL1BioGRID32807901 details
CDK4RPRMBioGRID, IntAct17353931 details
CDK4UBXN10BioGRID26389662 details
CDK4PTPN21BioGRID27432908 details
CDK4SSR1BioGRID, MINT24981860 details
CDK4RIN3BioGRID, IntAct32552912 details
CDK4VCPBioGRID23383273 details
CDK4GABARAPL1IntAct20562859 details
CDK4EIF1AXBioGRID26186194 details
CDK4ATXN3BioGRID29111377 details
CDK4RECQL4BioGRID29229926 details
CDK4DDX58BioGRID32513696 details
CDK4SIN3BIntAct24951594 details