Entity Details

Primary name TOPORS
Entity type gene
Source Source Link

Details

PrimaryID10210
RefseqGeneNG_017050
SymbolTOPORS
NameTOP1 binding arginine/serine rich protein, E3 ubiquitin ligase
Chromosome9
Location9p21.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-06-03
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsTOPRS_HUMAN

GO terms

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GOName
GO:0000151 ubiquitin ligase complex
GO:0000209 protein polyubiquitination
GO:0000922 spindle pole
GO:0000930 gamma-tubulin complex
GO:0003677 DNA binding
GO:0003823 antigen binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005814 centriole
GO:0006351 transcription, DNA-templated
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006513 protein monoubiquitination
GO:0006974 cellular response to DNA damage stimulus
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010842 retina layer formation
GO:0016605 PML body
GO:0016607 nuclear speck
GO:0016925 protein sumoylation
GO:0019789 SUMO transferase activity
GO:0030496 midbody
GO:0032391 photoreceptor connecting cilium
GO:0034504 protein localization to nucleus
GO:0035845 photoreceptor cell outer segment organization
GO:0036064 ciliary basal body
GO:0042127 regulation of cell population proliferation
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043066 negative regulation of apoptotic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0044547 DNA topoisomerase binding
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046548 retinal rod cell development
GO:0046549 retinal cone cell development
GO:0046872 metal ion binding
GO:0051443 positive regulation of ubiquitin-protein transferase activity
GO:0051457 maintenance of protein location in nucleus
GO:0061630 ubiquitin protein ligase activity
GO:0070936 protein K48-linked ubiquitination

Diseases

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Interactions

73 interactions

InteractorPartnerSourcesPublicationsLink
TOPORSSNIP1HPRD, MINT15231748 details
TOPORSTP53BioGRID, HPRD, MINT10415337 11842245 15247280 16122737 17290218 17803295 details
TOPORSCASP8BioGRID, HPRD, MINT17290218 details
TOPORSUBE2D1BioGRID, IntAct15247280 18077445 19053840 19690564 details
TOPORSUBE2D2BioGRID, IntAct19690564 details
TOPORSUBE2D3BioGRID, IntAct15247280 19690564 details
TOPORSUBE2D4BioGRID, IntAct19690564 details
TOPORSUBE2J1BioGRID, IntAct19690564 details
TOPORSUBE2L6BioGRID, IntAct19690564 details
TOPORSUBE2NBioGRID, IntAct19690564 details
TOPORSUBE2WBioGRID, IntAct19690564 details
TOPORSSATB1BioGRID, IntAct18408014 20351170 details
TOPORSSETXUniProt24244371 details
TOPORSUBE2IBioGRID, HPRD14516784 16122737 details
TOPORSSUMO1BioGRID, HPRD11842245 14516784 16524884 details
TOPORSTOP1BioGRID, HPRD10352183 17976381 20805487 details
TOPORSHABP4BioGRID, HPRD16455055 details
TOPORSSIN3ABioGRID17803295 details
TOPORSPLK1BioGRID19473992 19821153 22972498 details
TOPORSNKX3-1BioGRID18077445 details
TOPORSSERBP1BioGRID, HPRD16679534 details
TOPORSH2AXBioGRID22972498 details
TOPORSUBE2E1BioGRID15247280 details
TOPORSSUMO2BioGRID16524884 details
TOPORSMTDHBioGRID24529480 details
TOPORSUBCBioGRID15247280 details
TOPORSEPM2ABioGRID26493215 details
TOPORSPSMC1BioGRID26872363 details
TOPORSSPOPBioGRID29996942 details
TOPORSXRCC1BioGRID29668892 details
TOPORSCREBBPBioGRID28680062 details
TOPORSTOPORSHPRD11842245 details
TOPORSAPOEIntAct31413325 details
TOPORSGTF2IBioGRID17803295 details
TOPORSNONOBioGRID17803295 details
TOPORSSFPQBioGRID17803295 details
TOPORSPARP1BioGRID17803295 details
TOPORSSAFB2BioGRID17803295 details
TOPORSDDB2BioGRID17803295 details
TOPORSRBBP7BioGRID17803295 details
TOPORSTRIM28BioGRID17803295 details
TOPORSRBBP4BioGRID17803295 details
TOPORSSMARCC2BioGRID17803295 details
TOPORSDHX15BioGRID17803295 details
TOPORSHNRNPLBioGRID17803295 details
TOPORSRANGAP1BioGRID17803295 details
TOPORSUPF3ABioGRID17803295 details
TOPORSHNRNPMBioGRID17803295 details
TOPORSHNRNPA1BioGRID17803295 details
TOPORSSF3B1BioGRID17803295 details
TOPORSEEF1A1BioGRID17803295 details
TOPORSS100A9BioGRID17803295 details
TOPORSIKBKEBioGRID20188669 details
TOPORSPMLBioGRID20188669 details
TOPORSUBXN7BioGRID, IntAct18775313 26389662 details
TOPORSNKAPBioGRID, IntAct28514442 details
TOPORSZNF324BBioGRID, IntAct28514442 details
TOPORSCLK3BioGRID, IntAct28514442 details
TOPORSZNF263BioGRID, IntAct28514442 details
TOPORSPNNBioGRID, IntAct28514442 details
TOPORSNIFKBioGRID, IntAct26186194 28514442 details
TOPORSZC3H18BioGRID, IntAct28514442 details
TOPORSZNF786BioGRID, IntAct28514442 details
TOPORSZNF816BioGRID, IntAct28514442 details
TOPORSZNF214BioGRID, IntAct28514442 details
TOPORSSPIN2BBioGRID, IntAct26186194 28514442 details
TOPORSUBE2E3BioGRID, IntAct28514442 details
TOPORSSPIN1BioGRID, IntAct26186194 28514442 details
TOPORSLLGL2BioGRID, IntAct28514442 details
TOPORSTP53BP1BioGRID, UniProt29656893 details
TOPORSGSK3ABioGRID27684187 details
TOPORSRNF4BioGRID29180619 details
TOPORSBRD3BioGRID31753913 details