Search
News
Downloads
About
Help
Contact
Entity Details
Primary name
M4K2_HUMAN
Entity type
UniProt
Source
Source Link
Details
Accession
Q12851
EntryName
M4K2_HUMAN
FullName
Mitogen-activated protein kinase kinase kinase kinase 2
TaxID
9606
Evidence
evidence at protein level
Length
820
SequenceStatus
complete
DateCreated
2003-02-28
DateModified
2021-06-02
Ontological Relatives
Genes
MAP4K2
GO terms
Show/Hide Table
GO
Name
GO:0000139
Golgi membrane
GO:0004674
protein serine/threonine kinase activity
GO:0005524
ATP binding
GO:0006468
protein phosphorylation
GO:0006903
vesicle targeting
GO:0006955
immune response
GO:0007254
JNK cascade
GO:0007257
obsolete activation of JUN kinase activity
GO:0008349
MAP kinase kinase kinase kinase activity
GO:0016323
basolateral plasma membrane
GO:0031435
mitogen-activated protein kinase kinase kinase binding
GO:0035556
intracellular signal transduction
GO:0045087
innate immune response
GO:0046330
positive regulation of JNK cascade
GO:0106310
protein serine kinase activity
GO:0106311
protein threonine kinase activity
Subcellular Location
Show/Hide Table
Subcellular Location
Basolateral cell membrane
Cytoplasm
Golgi apparatus membrane
Domains
Show/Hide Table
Domain
Name
Category
Type
IPR000719
Protein kinase domain
Domain
Domain
IPR001180
Citron homology (CNH) domain
Domain
Domain
IPR011009
Protein kinase-like domain superfamily
Family
Homologous superfamily
IPR017441
Protein kinase, ATP binding site
Site
Binding site
IPR021160
Mitogen-activated protein (MAP) kinase kinase kinase kinase
Family
Family
Diseases
Show/Hide Table
Drugs
Show/Hide Table
Drug
Name
Source
Type
DB12010
Fostamatinib
Drugbank
small molecule
Interactions
14 interactions
Interactor
Partner
Sources
Publications
Link
M4K2_HUMAN
M3K1_HUMAN
BioGRID, IntAct
11784851
9712898
details
M4K2_HUMAN
DEFB1_HUMAN
BioGRID, MINT
21900206
details
M4K2_HUMAN
ROA2_HUMAN
BioGRID, MINT
21900206
details
M4K2_HUMAN
NACAD_HUMAN
BioGRID, MINT
21900206
details
M4K2_HUMAN
PRDX4_HUMAN
BioGRID, MINT
21900206
details
M4K2_HUMAN
KAIN_HUMAN
BioGRID, MINT
21900206
details
M4K2_HUMAN
U1SBP_HUMAN
BioGRID, MINT
21900206
details
M4K2_HUMAN
XRCC6_HUMAN
BioGRID, MINT
21900206
details
M4K2_HUMAN
POTE1_HUMAN
bhf-ucl, BioGRID
21044950
details
M4K2_HUMAN
MP2K4_HUMAN
BioGRID
9712898
details
M4K2_HUMAN
TRAF2_HUMAN
BioGRID, HPRD
9712898
details
M4K2_HUMAN
RAB8A_HUMAN
BioGRID, HPRD
8643544
details
M4K2_HUMAN
M3K11_HUMAN
BioGRID, HPRD, IntAct
11784851
details
M4K2_HUMAN
HS90B_HUMAN
IntAct
22939624
details
This website requires cookies in order to function. By using the site you are agreeing to this as outlined in our
Terms of Use
I Agree