Entity Details

Primary name ROCK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13464
EntryNameROCK1_HUMAN
FullNameRho-associated protein kinase 1
TaxID9606
Evidenceevidence at protein level
Length1354
SequenceStatuscomplete
DateCreated2004-05-24
DateModified2021-06-02

Ontological Relatives

GenesROCK1

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0000281 mitotic cytokinesis
GO:0001726 ruffle
GO:0001837 epithelial to mesenchymal transition
GO:0003180 aortic valve morphogenesis
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005814 centriole
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0006939 smooth muscle contraction
GO:0007159 leukocyte cell-cell adhesion
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007266 Rho protein signal transduction
GO:0010494 cytoplasmic stress granule
GO:0010506 regulation of autophagy
GO:0010508 positive regulation of autophagy
GO:0010613 positive regulation of cardiac muscle hypertrophy
GO:0010628 positive regulation of gene expression
GO:0016525 negative regulation of angiogenesis
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019828 aspartic-type endopeptidase inhibitor activity
GO:0022614 membrane to membrane docking
GO:0030027 lamellipodium
GO:0030036 actin cytoskeleton organization
GO:0030155 regulation of cell adhesion
GO:0030334 regulation of cell migration
GO:0030866 cortical actin cytoskeleton organization
GO:0031032 actomyosin structure organization
GO:0031175 neuron projection development
GO:0031267 small GTPase binding
GO:0032059 bleb
GO:0032091 negative regulation of protein binding
GO:0032956 regulation of actin cytoskeleton organization
GO:0034774 secretory granule lumen
GO:0035509 negative regulation of myosin-light-chain-phosphatase activity
GO:0042326 negative regulation of phosphorylation
GO:0043312 neutrophil degranulation
GO:0043410 positive regulation of MAPK cascade
GO:0045616 regulation of keratinocyte differentiation
GO:0045664 regulation of neuron differentiation
GO:0046872 metal ion binding
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048013 ephrin receptor signaling pathway
GO:0048156 tau protein binding
GO:0048598 embryonic morphogenesis
GO:0050321 tau-protein kinase activity
GO:0050900 leukocyte migration
GO:0050901 leukocyte tethering or rolling
GO:0051045 negative regulation of membrane protein ectodomain proteolysis
GO:0051451 myoblast migration
GO:0051492 regulation of stress fiber assembly
GO:0051893 regulation of focal adhesion assembly
GO:0051894 positive regulation of focal adhesion assembly
GO:0061157 mRNA destabilization
GO:0070168 negative regulation of biomineral tissue development
GO:0070507 regulation of microtubule cytoskeleton organization
GO:0071559 response to transforming growth factor beta
GO:0072518 Rho-dependent protein serine/threonine kinase activity
GO:0072659 protein localization to plasma membrane
GO:0090521 glomerular visceral epithelial cell migration
GO:0097746 blood vessel diameter maintenance
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:0110061 regulation of angiotensin-activated signaling pathway
GO:0140058 neuron projection arborization
GO:1900223 positive regulation of amyloid-beta clearance
GO:1900242 regulation of synaptic vesicle endocytosis
GO:1901888 regulation of cell junction assembly
GO:1902003 regulation of amyloid-beta formation
GO:1902430 negative regulation of amyloid-beta formation
GO:1902992 negative regulation of amyloid precursor protein catabolic process
GO:1903140 regulation of establishment of endothelial barrier
GO:1903347 negative regulation of bicellular tight junction assembly
GO:1905205 positive regulation of connective tissue replacement
GO:1990776 response to angiotensin
GO:2000114 regulation of establishment of cell polarity
GO:2000145 regulation of cell motility

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Cytoplasm
Golgi apparatus membrane

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000961 AGC-kinase, C-terminalDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011072 HR1 rho-binding domainDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR015008 ROCK, Rho binding domainDomainDomain
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020684 Rho-associated protein kinase 1/2FamilyFamily
IPR037310 Rho-associated protein kinase 1, HR1DomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB04707 HydroxyfasudilDrugbanksmall molecule
DB07876 (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINEDrugbanksmall molecule
DB08162 FasudilDrugbanksmall molecule
DB08756 Y-27632Drugbanksmall molecule
DB13165 RipasudilDrugbanksmall molecule
DB13931 NetarsudilDrugbanksmall molecule

Interactions

46 interactions

InteractorPartnerSourcesPublicationsLink
ROCK1_HUMANSMAD2_HUMANBioGRID, HPRD, MINT15231748 details
ROCK1_HUMANROCK1_HUMANHPRD, IntAct16249185 details
ROCK1_HUMANRHOA_HUMANBioGRID, HPRD, IntAct, MINT12773565 14660612 21281639 31431478 8798490 8816443 details
ROCK1_HUMANTS101_HUMANBioGRID, HPRD, MINT17853893 details
ROCK1_HUMANMYBPH_HUMANMINT22085929 details
ROCK1_HUMANMAGB4_HUMANBioGRID, IntAct25416956 26186194 28514442 details
ROCK1_HUMANRBTN2_HUMANBioGRID, IntAct25416956 details
ROCK1_HUMANF124A_HUMANBioGRID, IntAct25416956 details
ROCK1_HUMANCF206_HUMANBioGRID, IntAct25416956 details
ROCK1_HUMANRPC3_HUMANBioGRID, IntAct25416956 details
ROCK1_HUMANHMGB2_HUMANUniProt32867128 details
ROCK1_HUMANMPIP1_HUMANBioGRID, HPRD14657354 details
ROCK1_HUMANRND3_HUMANBioGRID, HPRD12773565 details
ROCK1_HUMANLIMK2_HUMANBioGRID, HPRD10436159 11018042 11340065 23082153 details
ROCK1_HUMANITSN2_HUMANBioGRID22558309 details
ROCK1_HUMANCASP3_HUMANBioGRID, HPRD11283607 18723680 details
ROCK1_HUMANCASP7_HUMANBioGRID18723680 details
ROCK1_HUMANIKKB_HUMANBioGRID24240172 details
ROCK1_HUMANTRI15_HUMANBioGRID25450970 details
ROCK1_HUMANUBE2T_HUMANBioGRID28162934 details
ROCK1_HUMANMLC1_HUMANBioGRID23082153 details
ROCK1_HUMANTPPP_HUMANBioGRID23093407 details
ROCK1_HUMANFRMD5_HUMANMINT25448675 details
ROCK1_HUMANMYH9_HUMANDIP26368311 details
ROCK1_HUMANPROF2_HUMANBioGRID, HPRD14517206 details
ROCK1_HUMANGAB1_HUMANBioGRID12748184 details
ROCK1_HUMANCOF1_HUMANBioGRID10436159 details
ROCK1_HUMANHGS_HUMANBioGRID26819309 details
ROCK1_HUMANSL9A1_HUMANBioGRID26819309 details
ROCK1_HUMANCDKN3_HUMANBioGRID24704824 details
ROCK1_HUMANRHBT1_HUMANBioGRID31431478 details
ROCK1_HUMANRHOC_HUMANHPRD8816443 details
ROCK1_HUMANRADI_HUMANHPRD9456324 details
ROCK1_HUMANUB2R1_HUMANHPRD16123592 details
ROCK1_HUMANVIME_HUMANHPRD9565595 details
ROCK1_HUMANMOES_HUMANHPRD9516463 9856983 details
ROCK1_HUMANLIMK1_HUMANHPRD10436159 10559936 10652353 11340065 details
ROCK1_HUMANMYPT1_HUMANHPRD10601309 11931630 12220642 12563012 12600888 9354661 details
ROCK1_HUMANDPYL2_HUMANHPRD10818093 12482610 details
ROCK1_HUMANDPYL1_HUMANHPRD12482610 details
ROCK1_HUMANIRS1_HUMANHPRD11739394 details
ROCK1_HUMANEZRI_HUMANHPRD10970850 11387207 details
ROCK1_HUMANDESM_HUMANHPRD10574968 details
ROCK1_HUMANRHG24_HUMANHPRD16862148 details
ROCK1_HUMANADDA_HUMANHPRD10209029 details
ROCK1_HUMANGFAP_HUMANHPRD2114109 2155236 7822264 9099667 details