Entity Details

Primary name ITPR1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ14643
EntryNameITPR1_HUMAN
FullNameInositol 1,4,5-trisphosphate receptor type 1
TaxID9606
Evidenceevidence at protein level
Length2758
SequenceStatuscomplete
DateCreated2001-11-02
DateModified2021-06-02

Ontological Relatives

GenesITPR1

GO terms

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GOName
GO:0001666 response to hypoxia
GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:0005509 calcium ion binding
GO:0005637 nuclear inner membrane
GO:0005730 nucleolus
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0005955 calcineurin complex
GO:0006816 calcium ion transport
GO:0007165 signal transduction
GO:0009791 post-embryonic development
GO:0010506 regulation of autophagy
GO:0014069 postsynaptic density
GO:0015085 calcium ion transmembrane transporter activity
GO:0015278 calcium-release channel activity
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016529 sarcoplasmic reticulum
GO:0019855 calcium channel inhibitor activity
GO:0030168 platelet activation
GO:0030658 transport vesicle membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0030667 secretory granule membrane
GO:0031088 platelet dense granule membrane
GO:0031094 platelet dense tubular network
GO:0031095 platelet dense tubular network membrane
GO:0032469 endoplasmic reticulum calcium ion homeostasis
GO:0035091 phosphatidylinositol binding
GO:0042045 epithelial fluid transport
GO:0048471 perinuclear region of cytoplasm
GO:0050796 regulation of insulin secretion
GO:0050849 negative regulation of calcium-mediated signaling
GO:0050882 voluntary musculoskeletal movement
GO:0051209 release of sequestered calcium ion into cytosol
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070679 inositol 1,4,5 trisphosphate binding
GO:0098685 Schaffer collateral - CA1 synapse
GO:0098695 inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels
GO:1903779 regulation of cardiac conduction

Subcellular Location

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Subcellular Location
Cytoplasm
Cytoplasmic vesicle
Endoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR000493 Inositol 1,4,5-trisphosphate receptorFamilyFamily
IPR000699 RIH domainDomainDomain
IPR005821 Ion transport domainDomainDomain
IPR013662 RyR/IP3R Homology associated domainDomainDomain
IPR014821 Inositol 1,4,5-trisphosphate/ryanodine receptorDomainDomain
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR016093 MIR motifDomainDomain
IPR035910 RyR/IP3 receptor binding core, RIH domain superfamilyFamilyHomologous superfamily
IPR036300 Mir domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00201 CaffeineDrugbanksmall molecule
DB03401 1D-myo-inositol 1,4,5-trisphosphateDrugbanksmall molecule
DB09462 GlycerinDrugbanksmall molecule
DB11590 ThimerosalDrugbanksmall molecule

Interactions

52 interactions

InteractorPartnerSourcesPublicationsLink
ITPR1_HUMANSTA13_HUMANBioGRID, HPRD, IntAct14697242 details
ITPR1_HUMANAKT1_HUMANBioGRID, DIP, IntAct18250332 24947355 details
ITPR1_HUMANCAH8_HUMANBioGRID, HPRD, IntAct12611586 26186194 28514442 details
ITPR1_HUMANKGP1_HUMANBioGRID, DIP, HPRD10724174 18757735 8132598 details
ITPR1_HUMANBCL2_HUMANBioGRID, DIP, HPRD15613488 19706527 details
ITPR1_HUMANB2L10_HUMANUniProt27995898 details
ITPR1_HUMANSAHH2_HUMANBioGRID, HPRD, UniProt12525476 27995898 details
ITPR1_HUMANERBB2_HUMANBioGRID, IntAct31980649 details
ITPR1_HUMANCABP1_HUMANBioGRID, HPRD12032348 14570872 14685260 details
ITPR1_HUMANTRPC4_HUMANBioGRID, HPRD11163362 14505576 details
ITPR1_HUMANRHOA_HUMANBioGRID, HPRD12766172 details
ITPR1_HUMANE41L1_HUMANBioGRID, HPRD12444087 12676536 details
ITPR1_HUMANFKB1A_HUMANBioGRID, HPRD16278292 9346894 details
ITPR1_HUMANKPCD_HUMANBioGRID20395553 details
ITPR1_HUMANBRCA1_HUMANBioGRID25645916 details
ITPR1_HUMANBECN1_HUMANBioGRID22082873 details
ITPR1_HUMANIPRI_HUMANHPRD16990268 details
ITPR1_HUMANRHG01_HUMANHPRD14697242 details
ITPR1_HUMANERP44_HUMANHPRD, IntAct15652484 details
ITPR1_HUMANGRP75_HUMANIntAct24947355 details
ITPR1_HUMANPPIF_HUMANIntAct24947355 details
ITPR1_HUMANCRTC2_HUMANDIP22495310 details
ITPR1_HUMANDISC1_HUMANIntAct31413325 details
ITPR1_HUMANLAT_HUMANMINT18056410 details
ITPR1_HUMANTRPC1_HUMANBioGRID14505576 details
ITPR1_HUMANTRPC3_HUMANBioGRID, HPRD11524429 12606542 14505576 15104175 15623527 9853757 details
ITPR1_HUMANTRPC5_HUMANBioGRID14505576 details
ITPR1_HUMANTRPC6_HUMANBioGRID14505576 details
ITPR1_HUMANSDC2_HUMANBioGRID12676536 details
ITPR1_HUMANIRAG1_HUMANBioGRID, HPRD10724174 details
ITPR1_HUMANBANK1_HUMANBioGRID, HPRD11782428 details
ITPR1_HUMANITPR3_HUMANBioGRID, HPRD7559486 details
ITPR1_HUMANERLN1_HUMANBioGRID19240031 details
ITPR1_HUMANERLN2_HUMANBioGRID17502376 19240031 25882839 details
ITPR1_HUMANTERA_HUMANBioGRID19240031 details
ITPR1_HUMANPSMD2_HUMANBioGRID17502376 details
ITPR1_HUMANAMFR_HUMANBioGRID17502376 details
ITPR1_HUMANUFD1_HUMANBioGRID17502376 details
ITPR1_HUMANCALM1_HUMANBioGRID17696464 details
ITPR1_HUMANCALM2_HUMANBioGRID17696464 details
ITPR1_HUMANCALM3_HUMANBioGRID17696464 details
ITPR1_HUMANRN170_HUMANBioGRID25882839 details
ITPR1_HUMANST7_HUMANBioGRID29395067 details
ITPR1_HUMANKAPCA_HUMANBioGRID, HPRD12529267 33957083 8132598 details
ITPR1_HUMANCDK1_HUMANHPRD14635192 16237118 details
ITPR1_HUMANCCNB1_HUMANHPRD16237118 details
ITPR1_HUMANLYN_HUMANHPRD11782428 details
ITPR1_HUMANFYN_HUMANHPRD14761954 details
ITPR1_HUMANRYR2_HUMANHPRD12754204 details
ITPR1_HUMANHOME2_HUMANHPRD9808459 details
ITPR1_HUMANHOME3_HUMANHPRD9808459 details
ITPR1_HUMANHOME1_HUMANHPRD9808459 details