Entity Details

Primary name GLI3
Entity type gene
Source Source Link

Details

PrimaryID2737
RefseqGeneNG_008434
SymbolGLI3
NameGLI family zinc finger 3
Chromosome7
Location7p14.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-17
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsGLI3_HUMAN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001656 metanephros development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001701 in utero embryonic development
GO:0002052 positive regulation of neuroblast proliferation
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005929 cilium
GO:0005930 axoneme
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007224 smoothened signaling pathway
GO:0007411 axon guidance
GO:0007442 hindgut morphogenesis
GO:0007507 heart development
GO:0008013 beta-catenin binding
GO:0008285 negative regulation of cell population proliferation
GO:0009952 anterior/posterior pattern specification
GO:0009954 proximal/distal pattern formation
GO:0016485 protein processing
GO:0016607 nuclear speck
GO:0017053 transcription repressor complex
GO:0021631 optic nerve morphogenesis
GO:0021766 hippocampus development
GO:0021775 smoothened signaling pathway involved in ventral spinal cord interneuron specification
GO:0021776 smoothened signaling pathway involved in spinal cord motor neuron cell fate specification
GO:0021798 forebrain dorsal/ventral pattern formation
GO:0021819 layer formation in cerebral cortex
GO:0021861 forebrain radial glial cell differentiation
GO:0022018 lateral ganglionic eminence cell proliferation
GO:0030318 melanocyte differentiation
GO:0030324 lung development
GO:0030850 prostate gland development
GO:0032332 positive regulation of chondrocyte differentiation
GO:0033077 T cell differentiation in thymus
GO:0035035 histone acetyltransferase binding
GO:0035108 limb morphogenesis
GO:0036033 mediator complex binding
GO:0042060 wound healing
GO:0042307 positive regulation of protein import into nucleus
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042733 embryonic digit morphogenesis
GO:0042826 histone deacetylase binding
GO:0043066 negative regulation of apoptotic process
GO:0043231 intracellular membrane-bounded organelle
GO:0043585 nose morphogenesis
GO:0043586 tongue development
GO:0043627 response to estrogen
GO:0045060 negative thymic T cell selection
GO:0045665 negative regulation of neuron differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045879 negative regulation of smoothened signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046638 positive regulation of alpha-beta T cell differentiation
GO:0046639 negative regulation of alpha-beta T cell differentiation
GO:0046872 metal ion binding
GO:0048557 embryonic digestive tract morphogenesis
GO:0048566 embryonic digestive tract development
GO:0048589 developmental growth
GO:0048593 camera-type eye morphogenesis
GO:0048702 embryonic neurocranium morphogenesis
GO:0048709 oligodendrocyte differentiation
GO:0060021 roof of mouth development
GO:0060364 frontal suture morphogenesis
GO:0060366 lambdoid suture morphogenesis
GO:0060367 sagittal suture morphogenesis
GO:0060594 mammary gland specification
GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO:0060840 artery development
GO:0060873 anterior semicircular canal development
GO:0060875 lateral semicircular canal development
GO:0061005 cell differentiation involved in kidney development
GO:0070242 thymocyte apoptotic process
GO:0071625 vocalization behavior
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0097421 liver regeneration
GO:0097542 ciliary tip
GO:0097546 ciliary base
GO:0120223 larynx morphogenesis
GO:1901620 regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO:1903010 regulation of bone development
GO:1990837 sequence-specific double-stranded DNA binding

Diseases

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Interactions

46 interactions

InteractorPartnerSourcesPublicationsLink
GLI3SUFUBioGRID, HPRD, IntAct10564661 24311597 29515120 details
GLI3CREBBPBioGRID, HPRD10075717 17000779 32238831 details
GLI3ZIC1BioGRID, HPRD11238441 details
GLI3ZIC2BioGRID, HPRD11238441 details
GLI3ZIC3BioGRID, HPRD11238441 17764085 details
GLI3MED12BioGRID17000779 details
GLI3BTRCBioGRID16371461 16705181 29429990 details
GLI3SKIBioGRID, HPRD12435627 details
GLI3PRKCABioGRID16371461 details
GLI3CSNK1A1BioGRID16371461 details
GLI3GSK3ABioGRID16371461 details
GLI3SPOPBioGRID26475525 27220849 28805822 29996942 31911863 details
GLI3RHOUBioGRID26598620 details
GLI3TAF9BioGRID26282181 details
GLI3STK36BioGRID, HPRD, IntAct10806483 25241761 details
GLI3YWHAEMINT19996099 details
GLI3SMAD1BioGRID, HPRD, IntAct25241761 9843199 details
GLI3CEP44BioGRID, IntAct27173435 unassigned1312 details
GLI3KLHL7BioGRID, IntAct27173435 unassigned1312 details
GLI3SKILIntAct24819706 details
GLI3HDAC1BioGRID12435627 details
GLI3USP7BioGRID26120032 details
GLI3ARBioGRID29429990 details
GLI3SMAD4HPRD9843199 details
GLI3SMAD2HPRD9843199 details
GLI3TWIST1HPRD12142027 details
GLI3SMAD3HPRD9843199 details
GLI3SOX2BioGRID, IntAct, MINT21532573 23667531 details
GLI3EGLN3BioGRID, IntAct26972000 details
GLI3THSD4BioGRID, IntAct28514442 details
GLI3CELA1BioGRID, IntAct28514442 details
GLI3RCCD1BioGRID, IntAct28514442 details
GLI3TOMM20BioGRID, IntAct29568061 details
GLI3WDR11MINT29263200 details
GLI3FBXW11BioGRID25515538 details
GLI3RNF4BioGRID29180619 details
GLI3PPP1CABioGRID29669786 details
GLI3BRD1BioGRID31753913 details
GLI3PHIPBioGRID31753913 details
GLI3SP100BioGRID31753913 details
GLI3TAF1BioGRID31753913 details
GLI3SYNE3BioGRID34079125 details
GLI3CHD7IntAct21532573 details
GLI3VIRMABioGRID29507755 details
GLI3MKRN2BioGRID32460013 details
GLI3DDX58BioGRID32513696 details