Entity Details

Primary name CASP8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ14790
EntryNameCASP8_HUMAN
FullNameCaspase-8
TaxID9606
Evidenceevidence at protein level
Length479
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesCASP8

GO terms

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GOName
GO:0001525 angiogenesis
GO:0001817 regulation of cytokine production
GO:0004197 cysteine-type endopeptidase activity
GO:0005123 death receptor binding
GO:0005164 tumor necrosis factor receptor binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007166 cell surface receptor signaling pathway
GO:0007507 heart development
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0009409 response to cold
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0019054 modulation by virus of host cellular process
GO:0030101 natural killer cell activation
GO:0030225 macrophage differentiation
GO:0031264 death-inducing signaling complex
GO:0031265 CD95 death-inducing signaling complex
GO:0031625 ubiquitin protein ligase binding
GO:0032025 response to cobalt ion
GO:0032355 response to estradiol
GO:0032496 response to lipopolysaccharide
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032991 protein-containing complex
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034612 response to tumor necrosis factor
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0035877 death effector domain binding
GO:0036462 TRAIL-activated apoptotic signaling pathway
GO:0039650 suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process
GO:0042110 T cell activation
GO:0042113 B cell activation
GO:0042802 identical protein binding
GO:0043005 neuron projection
GO:0043065 positive regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0044297 cell body
GO:0044877 protein-containing complex binding
GO:0045088 regulation of innate immune response
GO:0045121 membrane raft
GO:0045471 response to ethanol
GO:0045651 positive regulation of macrophage differentiation
GO:0045862 positive regulation of proteolysis
GO:0046677 response to antibiotic
GO:0051603 proteolysis involved in cellular protein catabolic process
GO:0060544 regulation of necroptotic process
GO:0060546 negative regulation of necroptotic process
GO:0060715 syncytiotrophoblast cell differentiation involved in labyrinthine layer development
GO:0070269 pyroptosis
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway
GO:0071260 cellular response to mechanical stimulus
GO:0071407 cellular response to organic cyclic compound
GO:0071550 death-inducing signaling complex assembly
GO:0097110 scaffold protein binding
GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process
GO:0097190 apoptotic signaling pathway
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097194 execution phase of apoptosis
GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis
GO:0097202 activation of cysteine-type endopeptidase activity
GO:0097264 self proteolysis
GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0097342 ripoptosome
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1901216 positive regulation of neuron death
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001309 Peptidase C14, p20 domainDomainDomain
IPR001875 Death effector domainDomainDomain
IPR002138 Peptidase C14, caspase non-catalytic subunit p10DomainDomain
IPR002398 Peptidase C14 familyFamilyFamily
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR015917 Peptidase C14A, caspase catalytic domainDomainDomain
IPR016129 Peptidase family C14A, His active siteSiteActive site
IPR029030 Caspase-like domain superfamilyFamilyHomologous superfamily
IPR033139 Peptidase family C14A, cysteine active siteSiteActive site
IPR033170 Caspase-8FamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB11752 Bryostatin 1Drugbanksmall molecule
DB12651 BardoxoloneDrugbanksmall molecule

Interactions

199 interactions

InteractorPartnerSourcesPublicationsLink
CASP8_HUMANC8AP2_HUMANBioGRID, HPRD, MINT10235259 11340079 17245429 details
CASP8_HUMANCASP8_HUMANBioGRID, HPRD, IntAct, MINT10964557 11717445 11832478 16169070 17170703 17290218 8681376 8962078 details
CASP8_HUMANCASPA_HUMANBioGRID, HPRD, IntAct, MINT11717445 11832478 12198154 12887920 15280356 15659383 170210 17159907 21737330 22864571 3031469 8962078 details
CASP8_HUMANFADD_HUMANBioGRID, DIP, HPIDb, HPRD, IntAct, MINT11717445 12107169 12702723 12887920 12911633 14612908 15280356 15659383 17047155 17159907 17290218 18485876 19060883 19176810 19524512 20103630 20448643 20829884 21458669 21525013 21620750 21737329 21737330 21785459 21988832 22173242 22179575 22274400 22864571 23142077 23429285 23955153 23972990 24098568 25043603 25911380 25939870 26437781 26972597 27321185 27552911 27560715 29497034 29795330 30561431 31046799 8681376 9228018 9343261 details
CASP8_HUMANBAP31_HUMANBioGRID, HPRD, IntAct, MINT11917123 12668660 15254227 21183955 9334338 details
CASP8_HUMANTRAF1_HUMANBioGRID, HPRD, IntAct11098060 11181075 12887920 details
CASP8_HUMANCFLAR_HUMANBioGRID, DIP, HPRD, IntAct, MINT11741985 12097160 12215447 12887920 15280356 17047155 17159907 19343040 19416807 19710364 21737329 21737330 22322857 22864571 24438025 26186194 28514442 31046799 9208847 9228018 9289491 9326610 9380701 details
CASP8_HUMANRIPK1_HUMANBioGRID, DIP, HPRD, IntAct, MINT10521396 11002417 12215447 12884866 12887920 17047155 18485876 18570872 19060883 19373245 19524512 19524513 19773432 20825417 21282461 21458669 21525013 21737329 21737330 22173242 22179575 22274400 22585859 22864571 23429285 23955153 23972990 24098568 24577083 25911380 25939870 26733177 26972597 27552911 27810922 29021293 29274253 29431638 33052227 details
CASP8_HUMANVIME_HUMANBioGRID, HPRD, IntAct10469173 11423904 16169070 details
CASP8_HUMANCHD3_HUMANBioGRID, HPRD, IntAct16169070 details
CASP8_HUMANTFCP2_HUMANBioGRID, HPRD, IntAct16169070 details
CASP8_HUMANTOPRS_HUMANBioGRID, HPRD, MINT17290218 details
CASP8_HUMANNUCB1_HUMANMINT18154733 details
CASP8_HUMANNUCB2_HUMANMINT18154733 details
CASP8_HUMANBCL2_HUMANBioGRID, HPRD, IntAct11406564 16183855 details
CASP8_HUMANTR10A_HUMANBioGRID, HPRD, IntAct12218097 15280356 15388581 17047155 19343040 19427028 20103630 21785459 23142077 27321185 28514442 29274253 29795330 9325248 details
CASP8_HUMANKPCI_HUMANBioGRID, IntAct21988832 details
CASP8_HUMANSMD3_HUMANBioGRID, IntAct21988832 details
CASP8_HUMANPDIA6_HUMANBioGRID, IntAct21988832 details
CASP8_HUMANPLIN4_HUMANIntAct21988832 details
CASP8_HUMANTR10B_HUMANBioGRID, HPRD, IntAct11940602 12218097 15388581 15659383 17047155 19343040 19432816 20103630 23142077 25043603 26186194 28514442 28972304 31443721 32313199 9325248 details
CASP8_HUMANMLP3B_HUMANBioGRID, MINT21900206 30941888 details
CASP8_HUMANPAR10_HUMANMINT23305266 details
CASP8_HUMANRNF34_HUMANBioGRID, UniProt15069192 details
CASP8_HUMANCNBP_HUMANBioGRID, MINT25640309 details
CASP8_HUMANAT1A3_HUMANBioGRID, MINT25640309 details
CASP8_HUMANB2L10_HUMANBioGRID, MINT25640309 details
CASP8_HUMANYBOX1_HUMANBioGRID, MINT25640309 details
CASP8_HUMANUMPS_HUMANBioGRID, MINT25640309 details
CASP8_HUMANHBP1_HUMANBioGRID, MINT25640309 details
CASP8_HUMANDHPR_HUMANBioGRID, MINT25640309 details
CASP8_HUMANSOX2_HUMANBioGRID, MINT25640309 details
CASP8_HUMANBEX1_HUMANBioGRID, MINT25640309 details
CASP8_HUMANAGR3_HUMANBioGRID, MINT25640309 details
CASP8_HUMANANGL4_HUMANBioGRID, MINT25640309 details
CASP8_HUMANBLID_HUMANBioGRID, MINT25640309 details
CASP8_HUMANCASC3_HUMANBioGRID, MINT25640309 details
CASP8_HUMANCAD13_HUMANBioGRID, MINT25640309 details
CASP8_HUMANESIP1_HUMANBioGRID, MINT25640309 details
CASP8_HUMANERRFI_HUMANBioGRID, MINT25640309 details
CASP8_HUMANGLCE_HUMANBioGRID, MINT25640309 details
CASP8_HUMANGREB1_HUMANBioGRID, MINT25640309 details
CASP8_HUMANI13R2_HUMANBioGRID, MINT25640309 details
CASP8_HUMANIL24_HUMANBioGRID, MINT25640309 details
CASP8_HUMANKLK5_HUMANBioGRID, MINT25640309 details
CASP8_HUMANKLK9_HUMANBioGRID, MINT25640309 details
CASP8_HUMANLYPD3_HUMANBioGRID, MINT25640309 details
CASP8_HUMANPRD14_HUMANBioGRID, MINT25640309 details
CASP8_HUMANHOP2_HUMANBioGRID, MINT25640309 details
CASP8_HUMANATAD2_HUMANBioGRID, MINT25640309 details
CASP8_HUMANBAP1_HUMANBioGRID, MINT25640309 details
CASP8_HUMANS10AE_HUMANBioGRID, MINT25640309 details
CASP8_HUMANSG2A2_HUMANBioGRID, MINT25640309 details
CASP8_HUMANSPB5_HUMANBioGRID, MINT25640309 details
CASP8_HUMANST14_HUMANBioGRID, MINT25640309 details
CASP8_HUMANTSP50_HUMANBioGRID, MINT25640309 details
CASP8_HUMANVPS45_HUMANBioGRID, MINT25640309 details
CASP8_HUMANNSD3_HUMANBioGRID, MINT25640309 details
CASP8_HUMANCASP3_HUMANBioGRID, DIP, HPRD11437602 11832478 15254227 18669646 8962078 details
CASP8_HUMANTNAP3_HUMANBioGRID, DIP19060883 26437781 28574503 details
CASP8_HUMANOSTP_HUMANDIP19706414 details
CASP8_HUMANNMT1_HUMANIntAct23150525 details
CASP8_HUMANVP33A_HUMANIntAct32814053 details
CASP8_HUMANUNG_HUMANIntAct32814053 details
CASP8_HUMANRAF1_HUMANIntAct32814053 details
CASP8_HUMANFMR1_HUMANIntAct32814053 details
CASP8_HUMANPLK1_HUMANIntAct32814053 details
CASP8_HUMANA4_HUMANHPRD, IntAct10911620 32814053 details
CASP8_HUMANBID_HUMANBioGRID, HPRD11085743 11832478 12097160 12196516 15659383 9727491 9727492 details
CASP8_HUMANNR1H4_HUMANBioGRID, HPRD11733517 details
CASP8_HUMANPEA15_HUMANBioGRID, HPRD10442631 10493725 details
CASP8_HUMANCASP6_HUMANBioGRID, HPRD11832478 12232792 8962078 details
CASP8_HUMANCASP7_HUMANBioGRID11832478 8962078 details
CASP8_HUMANCASP9_HUMANBioGRID11832478 8962078 details
CASP8_HUMANCASP2_HUMANBioGRID11832478 8962078 details
CASP8_HUMANDEDD2_HUMANBioGRID, HPRD11965497 12527898 details
CASP8_HUMANDEDD_HUMANBioGRID, HPRD11965497 12527898 9774341 details
CASP8_HUMANCASP4_HUMANBioGRID8962078 details
CASP8_HUMANCASP1_HUMANBioGRID8962078 details
CASP8_HUMANHDAC7_HUMANBioGRID18458084 details
CASP8_HUMANTRAF6_HUMANBioGRID16436380 16920630 27810922 30979779 details
CASP8_HUMANCSN6_HUMANBioGRID17337451 details
CASP8_HUMANBIRC6_HUMANBioGRID15507451 details
CASP8_HUMANUBC_HUMANBioGRID22585859 details
CASP8_HUMANPARK7_HUMANBioGRID21785459 details
CASP8_HUMANRB_HUMANBioGRID, HPRD15735701 details
CASP8_HUMANPA24B_HUMANBioGRID9875225 details
CASP8_HUMANGRAB_HUMANBioGRID17283187 details
CASP8_HUMANHECD3_HUMANBioGRID24287696 details
CASP8_HUMANPRDX6_HUMANBioGRID20829884 details
CASP8_HUMANATG4D_HUMANBioGRID19549685 details
CASP8_HUMANPARP1_HUMANBioGRID19549685 details
CASP8_HUMANPK3C3_HUMANBioGRID28846113 details
CASP8_HUMANSRC_HUMANBioGRID18089800 31286874 details
CASP8_HUMANTAU_HUMANBioGRID, HPRD12888622 details
CASP8_HUMANGMEB1_HUMANBioGRID, HPRD16497673 31046799 details
CASP8_HUMANAP1M1_HUMANBioGRID32296183 details
CASP8_HUMANBRD1_HUMANBioGRID32296183 details
CASP8_HUMANCCNL1_HUMANBioGRID32296183 details
CASP8_HUMANZN707_HUMANBioGRID32296183 details
CASP8_HUMANRNF31_HUMANBioGRID32122970 details
CASP8_HUMANOGT1_HUMANBioGRID32994395 details
CASP8_HUMANPIAS1_HUMANHPRD15782135 details
CASP8_HUMANSUMO1_HUMANHPRD15782135 details
CASP8_HUMANTNR6_HUMANBioGRID, DIP, HPRD, IntAct, MINT11101867 11717445 11978827 12887920 15659383 16498403 16554480 17047155 17159907 18328427 18787411 19483105 20956295 21625644 21713032 21803845 26186194 26942442 27321185 28514442 29795330 9208847 9325248 details
CASP8_HUMANTNF10_HUMANBioGRID, DIP, IntAct, MINT10894160 12198154 16554480 16801533 19427028 19432816 20097879 21459798 21525171 21822306 22266862 22585859 23142077 23678861 24287696 25551360 details
CASP8_HUMANTNFL6_HUMANBioGRID, DIP, IntAct, MINT12198154 12753742 12887920 15659383 16498403 21803845 24025841 details
CASP8_HUMANBIRC2_HUMANBioGRID, IntAct12887920 15069192 22274400 27810922 details
CASP8_HUMANTRADD_HUMANBioGRID, IntAct12887920 17047155 18776134 19524513 29108854 30561431 details
CASP8_HUMANTRAF2_HUMANBioGRID, HPRD, IntAct11340079 12887920 16227629 17047155 21282461 22179575 23142077 28972304 30054040 details
CASP8_HUMANTNR27_HUMANHPRD, IntAct15280356 details
CASP8_HUMANANDR_HUMANHPRD, MINT17170703 details
CASP8_HUMANNUCL_HUMANMINT17290218 details
CASP8_HUMANMK03_HUMANHPRD, MINT17290218 details
CASP8_HUMANMK01_HUMANBioGRID, HPRD, MINT17290218 details
CASP8_HUMANILK_HUMANHPRD, IntAct16936772 details
CASP8_HUMANNOL3_HUMANBioGRID, HPRD, IntAct18245485 25457551 9560245 details
CASP8_HUMANCUL3_HUMANBioGRID, IntAct19427028 23142077 25551360 28574503 details
CASP8_HUMANSQSTM_HUMANBioGRID, IntAct19427028 21628531 24121507 28574503 30941888 details
CASP8_HUMANOTU7B_HUMANIntAct19427028 details
CASP8_HUMANRIPK3_HUMANBioGRID, IntAct19524512 19524513 22864571 30420664 details
CASP8_HUMANBIP_HUMANIntAct19632185 details
CASP8_HUMANASM_HUMANMINT21157428 details
CASP8_HUMANTNR1A_HUMANBioGRID, MINT15659383 21157428 details
CASP8_HUMANM3K14_HUMANBioGRID, HPRD, IntAct11002417 12884866 details
CASP8_HUMANPTN6_HUMANMINT18086677 details
CASP8_HUMANMALT1_HUMANInnateDB22267217 details
CASP8_HUMANASC_HUMANBioGRID, InnateDB, UniProt12646168 22267217 30182366 details
CASP8_HUMANNLRC4_HUMANBioGRID, UniProt12646168 20085538 27974463 details
CASP8_HUMANRFFL_HUMANUniProt15069192 details
CASP8_HUMANB2CL1_HUMANDIP, HPRD11733517 9027312 details
CASP8_HUMANTM219_HUMANIntAct20353938 details
CASP8_HUMANEZRI_HUMANBioGRID15659383 details
CASP8_HUMANMK08_HUMANBioGRID15659383 details
CASP8_HUMANMOES_HUMANBioGRID15659383 details
CASP8_HUMANRHOA_HUMANBioGRID15659383 details
CASP8_HUMANGDIR1_HUMANBioGRID15659383 details
CASP8_HUMANRBP1_HUMANBioGRID, HPRD12887920 16227629 details
CASP8_HUMANAPAF_HUMANBioGRID, HPRD9539746 details
CASP8_HUMANNOD1_HUMANBioGRID, HPRD10329646 details
CASP8_HUMANHIP1_HUMANBioGRID, HPRD11788820 19934260 details
CASP8_HUMANIFT57_HUMANBioGRID11788820 details
CASP8_HUMANIKKA_HUMANBioGRID, HPRD11002417 details
CASP8_HUMANIKKB_HUMANBioGRID, HPRD11002417 details
CASP8_HUMANCASPE_HUMANBioGRID, HPRD9792675 details
CASP8_HUMANFAF1_HUMANBioGRID, HPRD12702723 21282461 28414080 details
CASP8_HUMANGNDS_HUMANBioGRID21525013 details
CASP8_HUMANPTEN_HUMANBioGRID15717329 details
CASP8_HUMANKHDR1_HUMANBioGRID21620750 details
CASP8_HUMANUBP2_HUMANBioGRID22179575 details
CASP8_HUMANT22D3_HUMANBioGRID20671745 details
CASP8_HUMANMLP3A_HUMANBioGRID21628531 details
CASP8_HUMANSRBS1_HUMANBioGRID12765336 details
CASP8_HUMANCEBPB_HUMANBioGRID11684016 details
CASP8_HUMANCLIP3_HUMANBioGRID22297296 details
CASP8_HUMANBFAR_HUMANBioGRID, HPRD10716992 details
CASP8_HUMANP53_HUMANBioGRID17290218 details
CASP8_HUMANLRRK2_HUMANBioGRID19176810 details
CASP8_HUMANCAR11_HUMANBioGRID18625728 details
CASP8_HUMANCRYAB_HUMANBioGRID23074197 details
CASP8_HUMANXIAP_HUMANBioGRID15069192 23074197 details
CASP8_HUMANTNFA_HUMANBioGRID24980434 details
CASP8_HUMANBAX_HUMANBioGRID15254227 details
CASP8_HUMANTCAM1_HUMANBioGRID21737330 33052227 details
CASP8_HUMANBIRC3_HUMANBioGRID15069192 27810922 details
CASP8_HUMANTLR3_HUMANBioGRID27810922 details
CASP8_HUMANOPTN_HUMANBioGRID27552911 details
CASP8_HUMANRYBP_HUMANBioGRID, HPRD11395500 27989698 details
CASP8_HUMANSPB9_HUMANBioGRID17479112 details
CASP8_HUMANMK14_HUMANBioGRID14970175 details
CASP8_HUMANPP2AA_HUMANBioGRID25551360 details
CASP8_HUMANBECN1_HUMANBioGRID29669822 details
CASP8_HUMANNLRP3_HUMANBioGRID30182366 details
CASP8_HUMANPML_HUMANBioGRID31153006 details
CASP8_HUMANIL1B_HUMANBioGRID32597834 details
CASP8_HUMANGSDMD_HUMANBioGRID32597834 details
CASP8_HUMANSKP2_HUMANBioGRID32313199 details
CASP8_HUMANE2AK2_HUMANHPRD11555640 details
CASP8_HUMANPSN2_HUMANHPRD10069390 9219695 9990034 details
CASP8_HUMANPLEC_HUMANHPRD10891503 details
CASP8_HUMANPICAL_HUMANHPRD10926122 details
CASP8_HUMANCRADD_HUMANHPRD11002417 details
CASP8_HUMANRIPK2_HUMANHPRD9575181 details
CASP8_HUMANM4K4_HUMANHPRD11002417 details
CASP8_HUMANGRIA1_HUMANHPRD11751897 details
CASP8_HUMANCDN1B_HUMANHPRD11420686 details
CASP8_HUMANPARP2_HUMANHPRD12065591 details
CASP8_HUMANCTNB1_HUMANHPRD12189238 details
CASP8_HUMANFYN_HUMANHPRD10435619 details
CASP8_HUMANK1C18_HUMANHPRD10891503 details
CASP8_HUMANNEMO_HUMANHPRD16227629 details
CASP8_HUMANSRF_HUMANHPRD11387340 details
CASP8_HUMANPCY1A_HUMANHPRD12052891 details
CASP8_HUMANPRKN_HUMANHPRD12692130 details
CASP8_HUMANCD11B_HUMANHPRD9632733 details
CASP8_HUMANSTK24_HUMANHPRD12107159 details
CASP8_HUMANUSO1_HUMANHPRD12438416 details
CASP8_HUMANKPCZ_HUMANHPRD11016947 details
CASP8_HUMANPSN1_HUMANHPRD10069390 details