Entity Details

Primary name PYCARD
Entity type gene
Source Source Link

Details

PrimaryID29108
RefseqGeneNG_029446
SymbolPYCARD
NamePYD and CARD domain containing
Chromosome16
Location16p11.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-03-05
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsASC_HUMAN

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0001773 myeloid dendritic cell activation
GO:0002020 protease binding
GO:0002218 activation of innate immune response
GO:0002230 positive regulation of defense response to virus by host
GO:0002277 myeloid dendritic cell activation involved in immune response
GO:0002588 positive regulation of antigen processing and presentation of peptide antigen via MHC class II
GO:0002821 positive regulation of adaptive immune response
GO:0005138 interleukin-6 receptor binding
GO:0005523 tropomyosin binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0008385 IkappaB kinase complex
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0010506 regulation of autophagy
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0017024 myosin I binding
GO:0019899 enzyme binding
GO:0030838 positive regulation of actin filament polymerization
GO:0031647 regulation of protein stability
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032090 Pyrin domain binding
GO:0032688 negative regulation of interferon-beta production
GO:0032722 positive regulation of chemokine production
GO:0032729 positive regulation of interferon-gamma production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032733 positive regulation of interleukin-10 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032991 protein-containing complex
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0034774 secretory granule lumen
GO:0035578 azurophil granule lumen
GO:0035590 purinergic nucleotide receptor signaling pathway
GO:0042104 positive regulation of activated T cell proliferation
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043025 neuronal cell body
GO:0043065 positive regulation of apoptotic process
GO:0043087 regulation of GTPase activity
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043312 neutrophil degranulation
GO:0044325 transmembrane transporter binding
GO:0044351 macropinocytosis
GO:0045087 innate immune response
GO:0046330 positive regulation of JNK cascade
GO:0046983 protein dimerization activity
GO:0050727 regulation of inflammatory response
GO:0050766 positive regulation of phagocytosis
GO:0050829 defense response to Gram-negative bacterium
GO:0050870 positive regulation of T cell activation
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051260 protein homooligomerization
GO:0051607 defense response to virus
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070700 BMP receptor binding
GO:0071222 cellular response to lipopolysaccharide
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0071901 negative regulation of protein serine/threonine kinase activity
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
GO:0072558 NLRP1 inflammasome complex
GO:0072559 NLRP3 inflammasome complex
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process
GO:0097169 AIM2 inflammasome complex
GO:0097202 activation of cysteine-type endopeptidase activity
GO:1900016 negative regulation of cytokine production involved in inflammatory response
GO:2000406 positive regulation of T cell migration
GO:2001056 positive regulation of cysteine-type endopeptidase activity
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
GO:2001242 regulation of intrinsic apoptotic signaling pathway

Diseases

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Interactions

64 interactions

InteractorPartnerSourcesPublicationsLink
PYCARDMEFVBioGRID, HPRD, IntAct, MINT11498534 12054656 12646168 17964261 25006247 details
PYCARDPRKAR1ABioGRID, HPRD, IntAct16189514 31515488 details
PYCARDAIM2BioGRID, DIP, InnateDB, IntAct, UniProt19158675 19158676 22286270 24237704 24630722 26121674 details
PYCARDNLRC4BioGRID, HPRD, UniProt11374873 12646168 details
PYCARDNLRP3BioGRID, DIP, HPRD, IntAct, UniProt11786556 15020601 19158675 24630722 28229991 30182366 30653357 32003754 32435622 details
PYCARDPYDC2HPRD, UniProt17178784 17339483 details
PYCARDCASP1BioGRID, HPRD, IntAct11967258 12019269 12191486 24630722 25605870 26121674 32435622 details
PYCARDPYCARDBioGRID, IntAct23209292 24407287 24630722 25006247 25416956 28247911 details
PYCARDEXOC5BioGRID, IntAct25416956 details
PYCARDSYKIntAct25605870 details
PYCARDUSP50BioGRID28094437 details
PYCARDNLRP1HPRD, IntAct17418785 details
PYCARDCASP8BioGRID, InnateDB, UniProt12646168 22267217 30182366 details
PYCARDLAMP1InnateDB22286270 details
PYCARDSQSTM1BioGRID, InnateDB22286270 32003754 details
PYCARDRALBBioGRID, InnateDB22286270 details
PYCARDBAXUniProt14730312 details
PYCARDCHUKBioGRID, UniProt12486103 details
PYCARDIKBKBBioGRID, UniProt12486103 details
PYCARDPYDC1UniProt17178784 details
PYCARDPMLBioGRID, HPIDb24407287 details
PYCARDRIPK1BioGRID, IntAct25402006 details
PYCARDPAK1BioGRID, IntAct25402006 details
PYCARDNLRC3IntAct25277106 details
PYCARDNLRP2BioGRID15456791 details
PYCARDIFI16BioGRID26121674 27764250 details
PYCARDBRCA1BioGRID26121674 details
PYCARDARIH2BioGRID29021376 details
PYCARDTRAF6BioGRID31034780 details
PYCARDZFP91BioGRID30182366 details
PYCARDHIF1ABioGRID32883954 details
PYCARDSRFHPRD10847592 details
PYCARDNLRP12HPRD12019269 details
PYCARDPOP1HPRD17178784 details
PYCARDMALT1InnateDB22267217 details
PYCARDBCL10InnateDB22267217 details
PYCARDCARD9InnateDB22267217 details
PYCARDBECN1BioGRID, InnateDB22286270 details
PYCARDIKBKGUniProt12486103 details
PYCARDDNAJC28BioGRID, HPIDb24407287 details
PYCARDTMPRSS15BioGRID, HPIDb24407287 details
PYCARDFSTL5BioGRID, HPIDb24407287 details
PYCARDNUP107BioGRID, HPIDb24407287 details
PYCARDTSHZ2BioGRID, HPIDb24407287 details
PYCARDMCM4BioGRID, HPIDb24407287 details
PYCARDIL6STBioGRID, HPIDb24407287 details
PYCARDMYO1CBioGRID, HPIDb24407287 details
PYCARDARMC2BioGRID, HPIDb24407287 details
PYCARDCEP131BioGRID, HPIDb24407287 details
PYCARDLEMD3BioGRID, HPIDb24407287 details
PYCARDINPP4BBioGRID, HPIDb24407287 details
PYCARDFAM184ABioGRID, HPIDb24407287 details
PYCARDPSTPIP1BioGRID, HPIDb24407287 details
PYCARDTPM4BioGRID, HPIDb24407287 details
PYCARDBMPR2BioGRID, HPIDb24407287 details
PYCARDLIG3BioGRID, HPIDb24407287 details
PYCARDDRC7BioGRID, HPIDb24407287 details
PYCARDNAA15BioGRID, HPIDb24407287 details
PYCARDBIRC5BioGRID, IntAct28514442 details
PYCARDCDK15BioGRID, IntAct28514442 details
PYCARDFCF1BioGRID, IntAct28514442 details
PYCARDPIGPBioGRID, IntAct28514442 details
PYCARDZYG11BBioGRID, IntAct28514442 details
PYCARDCUL2BioGRID, IntAct28514442 details