Entity Details

Primary name TWST1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15672
EntryNameTWST1_HUMAN
FullNameTwist-related protein 1
TaxID9606
Evidenceevidence at protein level
Length202
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesTWIST1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001503 ossification
GO:0001649 osteoblast differentiation
GO:0001701 in utero embryonic development
GO:0001764 neuron migration
GO:0001843 neural tube closure
GO:0003180 aortic valve morphogenesis
GO:0003183 mitral valve morphogenesis
GO:0003203 endocardial cushion morphogenesis
GO:0003253 cardiac neural crest cell migration involved in outflow tract morphogenesis
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007517 muscle organ development
GO:0008134 transcription factor binding
GO:0010628 positive regulation of gene expression
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling
GO:0019221 cytokine-mediated signaling pathway
GO:0019904 protein domain specific binding
GO:0030500 regulation of bone mineralization
GO:0032000 positive regulation of fatty acid beta-oxidation
GO:0032502 developmental process
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0033128 negative regulation of histone phosphorylation
GO:0035067 negative regulation of histone acetylation
GO:0035115 embryonic forelimb morphogenesis
GO:0035116 embryonic hindlimb morphogenesis
GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway
GO:0042473 outer ear morphogenesis
GO:0042476 odontogenesis
GO:0042733 embryonic digit morphogenesis
GO:0042803 protein homodimerization activity
GO:0043066 negative regulation of apoptotic process
GO:0043425 bHLH transcription factor binding
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045668 negative regulation of osteoblast differentiation
GO:0045766 positive regulation of angiogenesis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048511 rhythmic process
GO:0048642 negative regulation of skeletal muscle tissue development
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0050679 positive regulation of epithelial cell proliferation
GO:0060021 roof of mouth development
GO:0060363 cranial suture morphogenesis
GO:0060900 embryonic camera-type eye formation
GO:0061029 eyelid development in camera-type eye
GO:0070888 E-box binding
GO:0071363 cellular response to growth factor stimulus
GO:0071456 cellular response to hypoxia
GO:0071639 positive regulation of monocyte chemotactic protein-1 production
GO:2000144 positive regulation of DNA-templated transcription, initiation
GO:2000147 positive regulation of cell motility
GO:2000276 negative regulation of oxidative phosphorylation uncoupler activity
GO:2000679 positive regulation of transcription regulatory region DNA binding
GO:2000773 negative regulation of cellular senescence
GO:2000780 negative regulation of double-strand break repair
GO:2000793 cell proliferation involved in heart valve development
GO:2000802 positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domainDomainDomain
IPR015789 Twist-relatedFamilyFamily
IPR036638 Helix-loop-helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

57 interactions

InteractorPartnerSourcesPublicationsLink
TWST1_HUMANP53_HUMANBioGRID, IntAct18504427 22975381 25402006 details
TWST1_HUMANKAT2B_HUMANBioGRID, HPRD, IntAct10025406 18504427 details
TWST1_HUMANKMT5A_HUMANBioGRID, MINT21983900 details
TWST1_HUMANKAT5_HUMANIntAct24525235 details
TWST1_HUMANSTAT3_HUMANBioGRID, IntAct23623921 25814554 details
TWST1_HUMANITF2_HUMANBioGRID, IntAct, MINT19534813 25402006 25609649 28514442 details
TWST1_HUMANBCL6_HUMANBioGRID, IntAct25402006 details
TWST1_HUMANTYY1_HUMANBioGRID, IntAct25402006 details
TWST1_HUMANNEIL3_HUMANBioGRID, IntAct25402006 details
TWST1_HUMANTYY2_HUMANBioGRID, IntAct25402006 details
TWST1_HUMANZIC3_HUMANBioGRID, IntAct25402006 details
TWST1_HUMANTFE2_HUMANBioGRID, HPRD, IntAct10749989 11248247 20714342 22354994 details
TWST1_HUMANC1QBP_HUMANIntAct19534813 details
TWST1_HUMANARRD3_HUMANIntAct19534813 details
TWST1_HUMANCLUS_HUMANIntAct19534813 details
TWST1_HUMANHD_HUMANIntAct32814053 details
TWST1_HUMANEP300_HUMANBioGRID, HPRD10025406 details
TWST1_HUMANRBBP7_HUMANBioGRID20714342 details
TWST1_HUMANMTA2_HUMANBioGRID20714342 22457607 details
TWST1_HUMANCHD4_HUMANBioGRID20714342 details
TWST1_HUMANHXA5_HUMANBioGRID, HPRD15545268 details
TWST1_HUMANIKKB_HUMANBioGRID23375009 details
TWST1_HUMANIMA6_HUMANBioGRID23375009 details
TWST1_HUMANIMA8_HUMANBioGRID23375009 details
TWST1_HUMANZRAN1_HUMANBioGRID29748601 details
TWST1_HUMANTIF1B_HUMANBioGRID27412325 details
TWST1_HUMANPTEN_HUMANBioGRID30631154 details
TWST1_HUMANTRIB3_HUMANBioGRID31235507 details
TWST1_HUMANUBP18_HUMANBioGRID32368392 details
TWST1_HUMANETS2_HUMANBioGRID, IntAct18598946 details
TWST1_HUMANRBGP1_HUMANIntAct20195357 details
TWST1_HUMANTF65_HUMANBioGRID, HPRD, MINT12553906 21983900 details
TWST1_HUMANTWST1_HUMANHPRD, IntAct24525235 9343420 details
TWST1_HUMANBRD4_HUMANBioGRID, IntAct24525235 31311807 details
TWST1_HUMANNFKB1_HUMANDIP25266422 details
TWST1_HUMANG3BP2_HUMANDIP25893917 details
TWST1_HUMANSOX2_HUMANBioGRID21532573 details
TWST1_HUMANTWST2_HUMANBioGRID20714342 details
TWST1_HUMANESPB1_HUMANBioGRID20714342 details
TWST1_HUMANHDAC2_HUMANBioGRID20714342 22457607 details
TWST1_HUMANHDAC3_HUMANBioGRID21884981 details
TWST1_HUMANWDR5_HUMANBioGRID21884981 details
TWST1_HUMANCHD3_HUMANBioGRID22457607 details
TWST1_HUMANFBW1A_HUMANBioGRID23375009 26905590 28346424 details
TWST1_HUMANPAQR3_HUMANBioGRID26905590 details
TWST1_HUMANSKP2_HUMANBioGRID28346424 details
TWST1_HUMANU17L2_HUMANBioGRID29088851 details
TWST1_HUMANHDAC6_HUMANBioGRID28779345 details
TWST1_HUMANTBG1_HUMANBioGRID28779345 details
TWST1_HUMANVIME_HUMANBioGRID28779345 details
TWST1_HUMANCUL4A_HUMANBioGRID28779345 details
TWST1_HUMANRNF8_HUMANBioGRID29748601 details
TWST1_HUMANHIF1A_HUMANBioGRID23623921 details
TWST1_HUMANRD23A_HUMANBioGRID31487504 details
TWST1_HUMANUBP4_HUMANBioGRID32549341 details
TWST1_HUMANGLI3_HUMANHPRD12142027 details
TWST1_HUMANMYOD1_HUMANHPRD9343420 details