Entity Details

Primary name MDM4
Entity type gene
Source Source Link

Details

PrimaryID4194
RefseqGeneNG_029367
SymbolMDM4
NameMDM4 regulator of p53
Chromosome1
Location1q32.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-11-04
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsMDM4_HUMAN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0003170 heart valve development
GO:0003181 atrioventricular valve morphogenesis
GO:0003203 endocardial cushion morphogenesis
GO:0003281 ventricular septum development
GO:0003283 atrial septum development
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0008270 zinc ion binding
GO:0008285 negative regulation of cell population proliferation
GO:0016579 protein deubiquitination
GO:0019899 enzyme binding
GO:0030330 DNA damage response, signal transduction by p53 class mediator
GO:0042177 negative regulation of protein catabolic process
GO:0043066 negative regulation of apoptotic process
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050821 protein stabilization
GO:0065003 protein-containing complex assembly
GO:0071456 cellular response to hypoxia
GO:1901796 regulation of signal transduction by p53 class mediator

Diseases

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Interactions

107 interactions

InteractorPartnerSourcesPublicationsLink
MDM4MDM2BioGRID, DIP, HPRD, IntAct, MINT10218570 10608892 10629057 10827196 11606419 12370303 12393902 12483531 12860999 12874296 15604276 16055726 16227609 17159902 17301054 17616658 18219319 18566590 19432880 19619542 19683495 19838211 20473904 20484049 20705607 20724842 21925390 21988832 22120712 22266850 22333590 22493164 22745160 22902369 23028042 23671280 23946421 24755078 24813712 25105592 25384516 25512388 25659040 25703327 25809483 25825738 25961923 26001071 26359458 26720344 27215386 27617579 27621617 27777309 28205554 28514442 29057323 29262653 29295817 29523541 29524278 30598450 31024344 31796886 32075226 32427989 details
MDM4RB1BioGRID, HPRD, MINT16510145 25703327 details
MDM4CSNK1A1BioGRID, HPRD, IntAct, MINT16024788 16511560 17110929 21925390 23028042 25825738 28514442 29523541 30598450 31462704 details
MDM4YWHAGBioGRID, HPRD, MINT16511560 16511572 21148311 22556425 24190973 29523541 details
MDM4CHEK1BioGRID, HPRD, MINT16163388 16511572 details
MDM4TP53BioGRID, DIP, HPRD, IntAct, MINT10075736 10608892 10629057 10827196 11223036 11528400 12370303 12393902 12874296 15604276 15916963 16024788 16227609 17080083 17110929 17301054 17875722 18316739 18485870 18677113 19075013 19153082 19255450 19305137 19432880 19521340 20174603 20515689 20705607 20724842 21075307 21088494 21925390 21965653 22266850 22374672 22745160 22807444 23028042 23671280 23946421 24127580 24445145 24659749 24667498 25464845 25609649 25825738 25961923 26148237 26186194 26876197 27114532 28205554 28487147 28514442 29023092 29523541 30598450 30672125 30832340 31066983 31152661 31462704 8895579 9226370 details
MDM4UBCBioGRID, MINT17110929 24755078 details
MDM4USP7BioGRID, HPRD, IntAct, MINT15916963 18566590 20713061 31519875 details
MDM4MKRN3BioGRID, IntAct22493164 27107012 32296183 details
MDM4MNAT1BioGRID, IntAct22493164 details
MDM4TRIM46BioGRID, IntAct22493164 details
MDM4TRIM55BioGRID, IntAct22493164 details
MDM4LRSAM1BioGRID, IntAct22493164 details
MDM4UBE2D2BioGRID, IntAct20705607 24127580 details
MDM4CD160BioGRID, IntAct25416956 32296183 details
MDM4RNF115BioGRID, IntAct25416956 details
MDM4ZKSCAN3BioGRID, IntAct32296183 details
MDM4C1orf109BioGRID, IntAct32296183 details
MDM4WDR5BioGRID, IntAct32296183 details
MDM4VPS26CBioGRID, IntAct32296183 details
MDM4NAA10BioGRID, IntAct32296183 details
MDM4PELI1BioGRID, IntAct28514442 29523541 details
MDM4TP73BioGRID, HPRD, IntAct11223036 21088494 28514442 29523541 30603043 details
MDM4S100A1UniProt31837246 details
MDM4MDM4BioGRID, UniProt17301054 24127580 24755078 25888903 31837246 32075226 details
MDM4S100A2UniProt31837246 details
MDM4S100A5UniProt31837246 details
MDM4S100BBioGRID, UniProt17010455 31837246 details
MDM4SMAD3BioGRID, HPRD12483531 details
MDM4SMAD4BioGRID12483531 details
MDM4EP300BioGRID, HPRD12483531 details
MDM4E2F1BioGRID, HPRD12532331 details
MDM4UBE2D1BioGRID, HPRD12393902 17301054 details
MDM4CDKN2ABioGRID11297540 28205554 details
MDM4CHEK2BioGRID, HPRD16163388 details
MDM4CDKN1ABioGRID18086887 21148311 details
MDM4PSMD2BioGRID18086887 details
MDM4TP63BioGRID21088494 details
MDM4USP2BioGRID19838211 24445145 details
MDM4UBE2D3BioGRID19683495 details
MDM4APPBioGRID21832049 details
MDM4PRKAA1BioGRID24190973 details
MDM4CAPN7BioGRID25416956 details
MDM4RAD54BBioGRID25384516 details
MDM4SMARCA2BioGRID25384516 details
MDM4MAGEA1BioGRID25590999 details
MDM4CDK1BioGRID, HPRD15735705 details
MDM4ZKSCAN4BioGRID26871637 details
MDM4BECN1BioGRID28205554 details
MDM4CBLCBioGRID28205554 details
MDM4GLIS2BioGRID28205554 details
MDM4HGFBioGRID28205554 details
MDM4MAP2K5BioGRID28205554 details
MDM4CD44BioGRID28205554 details
MDM4CDK4BioGRID28205554 details
MDM4CDKN2BBioGRID28205554 details
MDM4EPHA2BioGRID28205554 details
MDM4FGFR4BioGRID28205554 details
MDM4LATS2BioGRID28205554 details
MDM4NF2BioGRID28205554 details
MDM4TOP2ABioGRID30672125 details
MDM4YWHABBioGRID, HPRD, MINT16227609 16511560 18356162 21925390 29523541 details
MDM4YWHAHBioGRID, HPRD, MINT16511560 29523541 details
MDM4YWHAZBioGRID, HPRD, IntAct, MINT16511560 18356162 28514442 details
MDM4YWHAEBioGRID, HPRD, MINT16227609 16511560 16511572 18356162 29523541 details
MDM4KPNA3MINT16511560 details
MDM4YWHAQBioGRID, HPRD, MINT16511560 17110929 18356162 29523541 details
MDM4SFNBioGRID, HPRD, MINT16511560 16511572 details
MDM4BCL2BioGRID, MINT19521340 24445145 details
MDM4HSP90AB1IntAct22939624 details
MDM4PSMC5BioGRID18086887 details
MDM4COP1BioGRID20333547 details
MDM4RCHY1BioGRID20333547 details
MDM4ABL1BioGRID19075013 details
MDM4PPP1CABioGRID23277204 details
MDM4PPP1CBBioGRID23277204 details
MDM4PPP1CCBioGRID23277204 details
MDM4HSP90AA1BioGRID22939624 details
MDM4RPL37BioGRID23874713 details
MDM4RPS15BioGRID23874713 details
MDM4RPS20BioGRID23874713 details
MDM4NBNBioGRID24608433 details
MDM4MRE11BioGRID24608433 details
MDM4RAD50BioGRID24608433 details
MDM4USP22BioGRID25547493 details
MDM4MAGEB1BioGRID25590999 details
MDM4HIPK2BioGRID25961923 details
MDM4MTORBioGRID28270148 details
MDM4ALBBioGRID24278348 details
MDM4RNF2BioGRID32427989 details
MDM4EZH2BioGRID32427989 details
MDM4CASP3HPRD11840332 details
MDM4AKT1HPRD16163388 details
MDM4ATMHPRD15788536 16163388 details
MDM4ARF1HPRD11297540 details
MDM4DAXXMINT18566590 details
MDM4UBA1IntAct20705607 details
MDM4SPATA46BioGRID, IntAct26186194 28514442 details
MDM4PPARDBioGRID, IntAct26186194 28514442 details
MDM4ASRGL1BioGRID, IntAct28514442 details
MDM4EIF2AK4BioGRID, IntAct28514442 details
MDM4FAM193ABioGRID, IntAct28514442 details
MDM4HBBBioGRID, IntAct28514442 details
MDM4CCNDBP1BioGRID, IntAct28514442 details
MDM4CSNK1A1LBioGRID29523541 details
MDM4HNRNPLBioGRID28611215 details
MDM4APEX1BioGRID28986522 details