Entity Details

Primary name NEFL
Entity type gene
Source Source Link

Details

PrimaryID4747
RefseqGeneNG_008492
SymbolNEFL
Nameneurofilament light chain
Chromosome8
Location8p21.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-12
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsNFL_HUMAN

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000226 microtubule cytoskeleton organization
GO:0005200 structural constituent of cytoskeleton
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005883 neurofilament
GO:0008022 protein C-terminus binding
GO:0008089 anterograde axonal transport
GO:0008090 retrograde axonal transport
GO:0009636 response to toxic substance
GO:0014012 peripheral nervous system axon regeneration
GO:0019896 axonal transport of mitochondrion
GO:0019904 protein domain specific binding
GO:0021510 spinal cord development
GO:0021766 hippocampus development
GO:0021987 cerebral cortex development
GO:0030424 axon
GO:0030426 growth cone
GO:0030674 protein-macromolecule adaptor activity
GO:0031133 regulation of axon diameter
GO:0031594 neuromuscular junction
GO:0033693 neurofilament bundle assembly
GO:0040011 locomotion
GO:0042802 identical protein binding
GO:0043274 phospholipase binding
GO:0043434 response to peptide hormone
GO:0043524 negative regulation of neuron apoptotic process
GO:0044877 protein-containing complex binding
GO:0045105 intermediate filament polymerization or depolymerization
GO:0045109 intermediate filament organization
GO:0048812 neuron projection morphogenesis
GO:0050772 positive regulation of axonogenesis
GO:0050885 neuromuscular process controlling balance
GO:0051258 protein polymerization
GO:0051412 response to corticosterone
GO:0060052 neurofilament cytoskeleton organization
GO:0060074 synapse maturation
GO:0098685 Schaffer collateral - CA1 synapse
GO:0098981 cholinergic synapse
GO:0099160 postsynaptic intermediate filament cytoskeleton
GO:0099182 presynaptic intermediate filament cytoskeleton
GO:0099184 structural constituent of postsynaptic intermediate filament cytoskeleton
GO:1903935 response to sodium arsenite
GO:1903937 response to acrylamide
GO:1904115 axon cytoplasm
GO:2000310 regulation of NMDA receptor activity

Diseases

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Interactions

196 interactions

InteractorPartnerSourcesPublicationsLink
NEFLCHD3BioGRID, HPRD, IntAct15383276 details
NEFLPIAS4BioGRID, HPRD, IntAct15383276 details
NEFLVIMBioGRID, HPRD, IntAct15383276 27173435 28514442 31944090 34079125 unassigned1312 details
NEFLBRD7BioGRID, HPRD, IntAct15383276 details
NEFLMTMR2HPRD, IntAct12837694 details
NEFLCDK5RAP2HPRD, IntAct16169070 details
NEFLPHLPP1MINT23455924 details
NEFLPRMT6BioGRID, MINT23455924 details
NEFLPPP1R18BioGRID, IntAct25416956 details
NEFLNDNBioGRID, IntAct24722188 26871637 32814053 details
NEFLTERF1bhf-ucl, BioGRID21044950 details
NEFLSKILBioGRID, IntAct26871637 32814053 details
NEFLKIFC3BioGRID, IntAct25416956 26871637 details
NEFLDESBioGRID, IntAct26871637 27107012 32296183 details
NEFLKLC3BioGRID, IntAct26871637 details
NEFLGORASP1BioGRID, IntAct26871637 details
NEFLGOLGA2BioGRID, IntAct26871637 details
NEFLGFAPBioGRID, IntAct26871637 32296183 32814053 details
NEFLKRT15BioGRID, IntAct25416956 26871637 details
NEFLKRT13BioGRID, IntAct26871637 details
NEFLKRT18BioGRID, IntAct26871637 details
NEFLCCDC172BioGRID, IntAct26871637 details
NEFLNEFMBioGRID, IntAct28514442 32296183 34079125 details
NEFLPKN1BioGRID, HPRD, IntAct32296183 8621664 details
NEFLCCDC13BioGRID, IntAct32296183 details
NEFLSMYD1BioGRID, IntAct32296183 details
NEFLUSP2BioGRID, IntAct25416956 32296183 details
NEFLNEK6BioGRID, IntAct32296183 details
NEFLNME7BioGRID, IntAct25416956 32296183 details
NEFLSYNCBioGRID, IntAct28514442 32814053 details
NEFLVDAC2IntAct32814053 details
NEFLTDGIntAct32814053 details
NEFLDYNLT1IntAct32814053 details
NEFLCLEC11AIntAct32814053 details
NEFLS100PIntAct32814053 details
NEFLMECP2IntAct32814053 details
NEFLLASP1IntAct32814053 details
NEFLKRT33BIntAct32814053 details
NEFLKRT19IntAct32814053 details
NEFLIL16IntAct32814053 details
NEFLFAHD1IntAct32814053 details
NEFLEYA3IntAct32814053 details
NEFLATP6V1B2IntAct32814053 details
NEFLANXA8IntAct32814053 details
NEFLANXA8L1IntAct32814053 details
NEFLAGAIntAct32814053 details
NEFLZSCAN9IntAct32814053 details
NEFLZKSCAN8IntAct32814053 details
NEFLZNF180IntAct32814053 details
NEFLCRLF3IntAct32814053 details
NEFLGPR75-ASB3IntAct32814053 details
NEFLASB3IntAct32814053 details
NEFLDCAF8IntAct32814053 details
NEFLTUBGCP4IntAct32814053 details
NEFLZNF436IntAct32814053 details
NEFLZC2HC1CIntAct32814053 details
NEFLFASTKD1IntAct32814053 details
NEFLTUT7IntAct32814053 details
NEFLTTC23IntAct32814053 details
NEFLEPS8L2IntAct32814053 details
NEFLELAPOR1IntAct32814053 details
NEFLNUFIP2IntAct32814053 details
NEFLPAK5IntAct32814053 details
NEFLZNF302IntAct32814053 details
NEFLRCOR3IntAct32814053 details
NEFLG2E3IntAct32814053 details
NEFLTASOR2IntAct32814053 details
NEFLGFOD1IntAct32814053 details
NEFLPELOIntAct32814053 details
NEFLMBIPIntAct32814053 details
NEFLARFGAP3IntAct32814053 details
NEFLSPAG8IntAct32814053 details
NEFLNSMFIntAct32814053 details
NEFLRYBPIntAct32814053 details
NEFLMLC1IntAct32814053 details
NEFLCYFIP1IntAct32814053 details
NEFLSNW1IntAct32814053 details
NEFLOIP5IntAct32814053 details
NEFLRAI2IntAct32814053 details
NEFLNEBLIntAct32814053 details
NEFLRBM14-RBM4IntAct32814053 details
NEFLRBM14IntAct32814053 details
NEFLKIAA0408IntAct32814053 details
NEFLBAG3IntAct32814053 details
NEFLSYT3IntAct32814053 details
NEFLCAMKK1IntAct32814053 details
NEFLFAM9AIntAct32814053 details
NEFLPPTC7IntAct32814053 details
NEFLC8orf48IntAct32814053 details
NEFLTCP10LIntAct32814053 details
NEFLZNF572IntAct32814053 details
NEFLC7orf31IntAct32814053 details
NEFLZNF57IntAct32814053 details
NEFLC17orf49IntAct32814053 details
NEFLZNF641IntAct32814053 details
NEFLZNF488IntAct32814053 details
NEFLRHPN1IntAct32814053 details
NEFLPGLYRP3IntAct32814053 details
NEFLTADA2BIntAct32814053 details
NEFLFANK1IntAct32814053 details
NEFLZNF829IntAct32814053 details
NEFLCFAP100IntAct32814053 details
NEFLVSX2IntAct32814053 details
NEFLKRTAP8-1IntAct32814053 details
NEFLMSRB3IntAct32814053 details
NEFLTSC1BioGRID, HPRD12226091 details
NEFLSPTAN1BioGRID, HPRD1902666 3121319 details
NEFLMAP2BioGRID1902666 details
NEFLKDM1ABioGRID23455924 details
NEFLCCNCBioGRID25416956 details
NEFLPDE4DIPBioGRID25416956 details
NEFLPPP1R16BBioGRID25416956 details
NEFLTEX11BioGRID25416956 26871637 details
NEFLENKD1BioGRID25416956 details
NEFLTXLNBBioGRID25416956 details
NEFLMTUS2BioGRID26871637 details
NEFLUSHBP1BioGRID26871637 details
NEFLCEP57L1BioGRID26871637 details
NEFLCCDC33BioGRID26871637 details
NEFLHGSBioGRID26871637 details
NEFLMYO15BBioGRID32296183 details
NEFLTRIM55BioGRID31391242 details
NEFLTRIM63BioGRID31391242 details
NEFLGRIN1HPRD9425014 details
NEFLHSPB3IntAct16169070 details
NEFLRANIntAct16169070 details
NEFLTNFIntAct20195357 details
NEFLSCHIP1IntAct20195357 details
NEFLNEFHBioGRID, HPRD, IntAct28514442 9388258 details
NEFLTNIKIntAct31413325 details
NEFLDISC1IntAct31413325 details
NEFLPICK1IntAct31413325 details
NEFLFXR1MINT21653829 details
NEFLPPP1CCBioGRID17683050 details
NEFLGANBioGRID26460568 details
NEFLARBioGRID28611094 details
NEFLNEFLHPRD15383276 details
NEFLMYO5AHPRD12403814 details
NEFLYWHAGBioGRID, HPRD, MINT15324660 details
NEFLAPPBioGRID, IntAct16049941 25241761 details
NEFLKSR1IntAct27086506 details
NEFLBICD1BioGRID, IntAct28514442 details
NEFLRMC1BioGRID, IntAct28514442 details
NEFLBICD2BioGRID, IntAct28514442 details
NEFLDPP9BioGRID, IntAct28514442 details
NEFLFAM83HBioGRID, IntAct28514442 details
NEFLRABEP1BioGRID, IntAct28514442 details
NEFLSEC16ABioGRID, IntAct28514442 details
NEFLRSPRY1BioGRID, IntAct28514442 details
NEFLLRRK2IntAct31046837 details
NEFLPRNPBioGRID, UniProt29791485 details
NEFLHTTBioGRID, UniProt25959826 details
NEFLARHGAP23BioGRID, IntAct32203420 details
NEFLECT2LBioGRID, IntAct32203420 details
NEFLDEPDC1BBioGRID, IntAct32203420 details
NEFLSIRT7BioGRID22586326 details
NEFLPRKNBioGRID24244333 details
NEFLOBSL1BioGRID24711643 details
NEFLCCDC8BioGRID24711643 details
NEFLHOXB5BioGRID26186194 details
NEFLMRPL4BioGRID26186194 details
NEFLSKAP1BioGRID26186194 details
NEFLPSG9BioGRID26186194 details
NEFLPHAF1BioGRID26186194 details
NEFLCRYABBioGRID26186194 details
NEFLCDC14ABioGRID27880917 details
NEFLSUZ12BioGRID27634302 details
NEFLPSMD14BioGRID30745168 details
NEFLCITBioGRID31586073 details
NEFLANLNBioGRID31586073 details
NEFLCHMP4BBioGRID31586073 details
NEFLECT2BioGRID31586073 details
NEFLKIF14BioGRID31586073 details
NEFLKIF20ABioGRID31586073 details
NEFLPRC1BioGRID31586073 details
NEFLARHGAP42BioGRID32203420 details
NEFLARHGEF19BioGRID32203420 details
NEFLARHGEF25BioGRID32203420 details
NEFLFGD4BioGRID32203420 details
NEFLGMIPBioGRID32203420 details
NEFLMCF2BioGRID32203420 details
NEFLNGEFBioGRID32203420 details
NEFLCHCHD1BioGRID32877691 details
NEFLCOX15BioGRID32877691 details
NEFLCRYZBioGRID32877691 details
NEFLHAX1BioGRID32877691 details
NEFLMARCHF5BioGRID32877691 details
NEFLMCUBBioGRID32877691 details
NEFLMTCH2BioGRID32877691 details
NEFLOCIAD1BioGRID32877691 details
NEFLSAMM50BioGRID32877691 details
NEFLSLC25A46BioGRID32877691 details
NEFLSLC25A51BioGRID32877691 details
NEFLSURF1BioGRID32877691 details
NEFLBCAR1BioGRID33001583 details
NEFLTNIP2BioGRID27609421 details