Entity Details

Primary name NFKBIA
Entity type gene
Source Source Link

Details

PrimaryID4792
RefseqGeneNG_007571
SymbolNFKBIA
NameNFKB inhibitor alpha
Chromosome14
Location14q13.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-21
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsIKBA_HUMAN

GO terms

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GOName
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006606 protein import into nucleus
GO:0006915 apoptotic process
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007253 cytoplasmic sequestering of NF-kappaB
GO:0008134 transcription factor binding
GO:0008139 nuclear localization sequence binding
GO:0010745 negative regulation of macrophage derived foam cell differentiation
GO:0010875 positive regulation of cholesterol efflux
GO:0010888 negative regulation of lipid storage
GO:0016032 viral process
GO:0016579 protein deubiquitination
GO:0019899 enzyme binding
GO:0031625 ubiquitin protein ligase binding
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032270 positive regulation of cellular protein metabolic process
GO:0032495 response to muramyl dipeptide
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0033256 I-kappaB/NF-kappaB complex
GO:0034142 toll-like receptor 4 signaling pathway
GO:0035994 response to muscle stretch
GO:0042127 regulation of cell population proliferation
GO:0042802 identical protein binding
GO:0042994 cytoplasmic sequestering of transcription factor
GO:0043066 negative regulation of apoptotic process
GO:0043330 response to exogenous dsRNA
GO:0043392 negative regulation of DNA binding
GO:0045638 negative regulation of myeloid cell differentiation
GO:0045746 negative regulation of Notch signaling pathway
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050729 positive regulation of inflammatory response
GO:0051059 NF-kappaB binding
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0070417 cellular response to cold
GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0070498 interleukin-1-mediated signaling pathway
GO:1901222 regulation of NIK/NF-kappaB signaling

Diseases

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Interactions

207 interactions

InteractorPartnerSourcesPublicationsLink
NFKBIABTRCBioGRID, HPRD, IntAct, MINT10066435 10075690 10497169 10644755 10713156 11027288 12482991 19053519 19933270 20353940 20558726 20638939 20797629 20851351 22022389 22388891 22590978 24464578 24912152 25190485 25900982 27001857 29499133 32051583 9859996 9990852 9990853 details
NFKBIASLC25A5HPRD, IntAct11287411 14743216 details
NFKBIANFKB1BioGRID, DIP, HPRD, IntAct, MINT11020244 11313474 14743216 16210649 17003112 20237821 20558726 20980497 21483817 21988832 22536447 25609649 26186194 26496610 27609421 28514442 29439025 7739549 7891711 8631829 8887676 9566883 9572494 9738011 9865693 details
NFKBIAVCPBioGRID, HPRD, IntAct10930447 14743216 23383273 23393163 24248593 26463447 9452483 details
NFKBIAFBXW11BioGRID, HPRD, IntAct10066435 10230406 10644755 12165731 12482991 14743216 17698585 24912152 26186194 27565346 28514442 details
NFKBIAPTPN13BioGRID, HPRD, IntAct11106428 14743216 9882613 details
NFKBIARELABioGRID, DIP, HPRD, I2D, IntAct, MINT, UniProt10066434 10085161 10498867 11020244 11231305 11287411 11313474 11533489 12419806 14685242 14690596 14743216 15657065 15799966 16105840 16280327 16683270 16951195 17003112 17301240 17362989 17612295 17709515 18045535 19219072 20065107 20551178 20797629 20876301 20980497 21217772 21483817 21988832 22022389 22081069 23185316 23563313 23850221 24248593 24457201 24634218 25520503 25609694 25759022 26186194 26463447 26476452 26496610 27609421 27923823 28514442 29084252 29439025 29734393 30213788 30542119 30628021 7628694 7739549 7878004 8139561 8246997 8657102 8887627 8887633 8978697 9057089 9566883 9572494 9738011 9751059 9865693 9990853 details
NFKBIANFKBIBBioGRID, HPRD, IntAct14743216 22081069 26186194 28514442 details
NFKBIAELP1BioGRID, HPRD, IntAct14743216 9751059 details
NFKBIACHUKBioGRID, HPRD, InnateDB, IntAct, UniProt10094049 10733566 11042193 11080499 11095741 11113112 11809792 11940602 12054687 12138192 12190313 12411322 12486103 12624112 12730857 14743216 15310755 15389589 15590691 15670770 16219905 16286467 16319058 16354686 17053167 17363905 17379600 17384642 18003900 18074035 18501560 18519641 18922877 18949366 19959994 20133937 20434986 20449947 20932476 21765415 23602409 24270572 24618592 26186194 28514442 29958295 9244310 9252186 9346485 9520446 9689078 9721103 9751059 9914500 details
NFKBIAIKBKBBioGRID, DIP, HPRD, InnateDB, IntAct, MINT, UniProt11080499 12054687 12411322 12486103 12624112 12709429 12943667 14743216 15125833 15125834 15217903 15218148 15456896 15919917 16126728 16286467 16291755 16319058 16365431 16611882 17079871 17363905 18202307 18375836 18519641 18593939 18981174 19196987 19345327 19959994 20434986 20449947 20797629 21399639 21423167 21765415 22022389 22037600 22904686 22990857 23816567 24469399 24611898 24618592 24912152 25595906 25759022 26221961 26740240 26802121 27387502 27497262 28214532 29650758 29958295 30254148 32555320 9346485 9520446 9689078 9721103 9751059 9891086 9914500 details
NFKBIAIKBKGBioGRID, HPRD, I2D, IntAct, MINT11064457 11830587 14743216 15218148 15670770 15749833 16126728 16319058 16547522 17363973 18429822 18519641 18957422 19959994 21217772 21811235 21862596 21896478 22081069 23732909 23746843 26496610 26865630 32246052 details
NFKBIASKP1BioGRID, HPRD, IntAct10066435 10230406 10514433 14743216 22590978 24912152 29499133 9990852 details
NFKBIAMED19BioGRID, HPRD, IntAct16169070 details
NFKBIAPOM121BioGRID, HPRD, IntAct16189514 32296183 details
NFKBIARWDD3BioGRID, IntAct17956732 details
NFKBIAATF4BioGRID, IntAct18255255 details
NFKBIAZNF212BioGRID, IntAct18255255 details
NFKBIAIKZF4BioGRID, IntAct18255255 details
NFKBIAPTPN1HPRD, MINT8940099 details
NFKBIAARRB1BioGRID, HPRD, IntAct15125834 15173580 19879840 details
NFKBIAPIK3R1BioGRID, HPRD, MINT9892650 details
NFKBIACD7BioGRID, IntAct21988832 details
NFKBIAPOLR2CBioGRID, IntAct21988832 details
NFKBIAST7BioGRID, IntAct21988832 details
NFKBIAHIF1ANBioGRID, DIP, IntAct17003112 26186194 26972000 28514442 details
NFKBIANEDD9BioGRID, IntAct25416956 32296183 details
NFKBIAPSMD3BioGRID, IntAct32296183 details
NFKBIAENKD1BioGRID, IntAct32296183 details
NFKBIATCL1ABioGRID, IntAct32296183 details
NFKBIAGRK5DIP19008357 details
NFKBIAGRK2DIP19008357 details
NFKBIASUMO4BioGRID, HPRD15247916 19222990 details
NFKBIAPIRBioGRID10362352 details
NFKBIABARD1BioGRID10362352 details
NFKBIATP53BioGRID, HPRD11799106 15969767 details
NFKBIAHNRNPA1BioGRID, HPRD11313474 details
NFKBIADYNLL1BioGRID, HPRD9372968 details
NFKBIARPS6KA1BioGRID, HPRD10723127 8601309 9214631 9261139 9721103 9914500 details
NFKBIAG3BP2BioGRID, HPRD10969074 details
NFKBIACAPN1BioGRID, HPRD10521480 details
NFKBIAMAP3K14BioGRID9751059 details
NFKBIALYL1BioGRID10023675 details
NFKBIAHOXB7BioGRID, HPRD10026139 details
NFKBIAUBE2D1BioGRID9362451 9409737 details
NFKBIAAURKABioGRID17060341 details
NFKBIAPSMA2BioGRID16098527 details
NFKBIAABL1BioGRID12167702 details
NFKBIASLC25A4BioGRID, HPRD11287411 details
NFKBIACDC34BioGRID, HPRD10329681 20347421 details
NFKBIACSNK2BBioGRID10398585 20797629 details
NFKBIAUBE2D3BioGRID, HPRD10329681 20347421 details
NFKBIAUBE2D2BioGRID, HPRD10329681 details
NFKBIAUBE2L3BioGRID10329681 details
NFKBIARPS6KA3BioGRID22685297 details
NFKBIAITPK1BioGRID12324474 details
NFKBIAMAP3K1BioGRID14500727 details
NFKBIADNAJA3BioGRID15601829 details
NFKBIAIKBKEBioGRID, HPRD10421793 20449947 details
NFKBIATBK1BioGRID, HPRD10783893 20449947 8601309 9721103 details
NFKBIAARRB2BioGRID, HPRD15125834 15173580 details
NFKBIAPRKCABioGRID10398585 details
NFKBIATNFBioGRID7739525 details
NFKBIAUBE2IBioGRID9409737 9734360 details
NFKBIAMAP3K7BioGRID15327770 details
NFKBIACASRBioGRID19456861 details
NFKBIARNF115BioGRID28122985 details
NFKBIAUBE2E3HPRD10582246 9409737 9734360 details
NFKBIARELBioGRID, HPRD, IntAct10706725 14743216 25759022 26186194 26496610 27609421 28514442 8887627 details
NFKBIAHSPA1LIntAct14743216 details
NFKBIAHSPA5IntAct14743216 details
NFKBIAHSPA8IntAct14743216 details
NFKBIARPS27LIntAct14743216 details
NFKBIAHSPA9IntAct14743216 details
NFKBIARPL23IntAct14743216 details
NFKBIAPOLRMTBioGRID, IntAct14743216 26186194 28514442 details
NFKBIAMCM3IntAct14743216 details
NFKBIANFKBIAHPRD, IntAct14743216 16951195 details
NFKBIAACTG1IntAct14743216 details
NFKBIACLTCIntAct14743216 details
NFKBIATIMM50IntAct14743216 details
NFKBIACALM1IntAct14743216 details
NFKBIACALM2IntAct14743216 details
NFKBIACALM3IntAct14743216 details
NFKBIASPRR3IntAct14743216 details
NFKBIATUBBIntAct14743216 details
NFKBIATUBB4AIntAct14743216 details
NFKBIANFKB2BioGRID, HPRD, IntAct14743216 26186194 26496610 28514442 details
NFKBIAELP3IntAct14743216 details
NFKBIAANXA1IntAct14743216 details
NFKBIATUBA3DIntAct14743216 details
NFKBIATUBA3CIntAct14743216 details
NFKBIATUBA1AIntAct14743216 details
NFKBIARELBBioGRID, IntAct14743216 19219072 26186194 27609421 28514442 details
NFKBIAMCM5HPRD, IntAct14743216 details
NFKBIAMCM7HPRD, IntAct14743216 details
NFKBIACOPS2BioGRID, MINT17318178 details
NFKBIAUBCMINT17318178 18539148 details
NFKBIATGM2BioGRID, IntAct16951195 23185316 details
NFKBIACOMMD1BioGRID, HPRD, IntAct14685242 16573520 20068069 25520503 details
NFKBIARPS3BioGRID, IntAct, MINT18045535 24457201 32555320 details
NFKBIACUL1BioGRID, HPRD, MINT10066435 10713156 11027288 11483504 14743216 17914462 22590978 29499133 details
NFKBIAPCBD1IntAct20195357 details
NFKBIARANIntAct24855949 details
NFKBIASRCBioGRID, HPRD, IntAct12429743 26186194 28514442 8797825 9792645 details
NFKBIACTNNA1DIP24509793 details
NFKBIAPSMA4BioGRID, DIP24509793 9875328 details
NFKBIAEP300BioGRID, IntAct19456861 21483817 details
NFKBIANCOR2BioGRID, HPRD12589049 15536134 details
NFKBIAHDAC3BioGRID, HPRD12972430 16371367 details
NFKBIANCOR1BioGRID15536134 details
NFKBIAHDAC1BioGRID, HPRD12972430 15536134 details
NFKBIAHDAC2BioGRID15536134 details
NFKBIAHDAC4BioGRID15536134 details
NFKBIAHDAC5BioGRID15536134 details
NFKBIACLUBioGRID20068069 details
NFKBIAMALT1BioGRID20551178 details
NFKBIABCL10BioGRID20551178 details
NFKBIACSNK1A1BioGRID20551178 details
NFKBIAHNRNPUBioGRID20797629 details
NFKBIAMAPK14BioGRID20797629 details
NFKBIAFBXW8BioGRID20558726 details
NFKBIAERC1BioGRID15218148 details
NFKBIAPIN1BioGRID14690596 details
NFKBIASOCS3BioGRID21451109 details
NFKBIAZBTB7ABioGRID15917220 details
NFKBIAPSMA1BioGRID23393163 details
NFKBIASTAT1BioGRID16481475 details
NFKBIAGPS1BioGRID23818606 details
NFKBIACOPS3BioGRID23818606 details
NFKBIAUFD1BioGRID24248593 details
NFKBIANPLOC4BioGRID24248593 details
NFKBIAMTORBioGRID18519641 details
NFKBIAMAVSBioGRID25636800 details
NFKBIARNF183BioGRID26818663 details
NFKBIARNF121BioGRID25388546 details
NFKBIAAKT1BioGRID11278366 details
NFKBIAASB2BioGRID30116272 details
NFKBIARBBP6BioGRID31685801 details
NFKBIAVIMBioGRID22536447 details
NFKBIAFBXW7BioGRID31945730 details
NFKBIAHECTD1BioGRID32555320 details
NFKBIASUMO1HPRD9734360 details
NFKBIACSNK2A1HPRD10398585 8622692 details
NFKBIANKIRAS1HPRD10657303 details
NFKBIAJAK2HPRD11493922 details
NFKBIAPRKCIHPRD10848576 details
NFKBIAMAP3K3HPRD10085062 details
NFKBIANKIRAS2HPRD10657303 details
NFKBIAHSPB1HPRD12897149 details
NFKBIAMAP3K2HPRD10085062 details
NFKBIACOPS8HPRD17318178 details
NFKBIACAPN2HPRD9873017 details
NFKBIAHOXA9HPRD15161102 details
NFKBIALCKHPRD12429743 8797825 9792645 details
NFKBIAEIF2AK2HPRD10723127 8601309 9214631 9721103 details
NFKBIATUBA1BHPRD9372968 details
NFKBIATNFSF11HPRD10635328 details
NFKBIAROCK2IntAct12730857 details
NFKBIACENPFBioGRID, IntAct26496610 details
NFKBIANFKBIEBioGRID, IntAct26496610 details
NFKBIAARHGAP39BioGRID, IntAct26496610 details
NFKBIAMED31BioGRID, IntAct26496610 details
NFKBIACOL7A1BioGRID, IntAct26496610 details
NFKBIAAVL9BioGRID, IntAct26496610 details
NFKBIATBC1D24BioGRID, IntAct26186194 28514442 details
NFKBIAPPP1R9ABioGRID, IntAct26186194 28514442 details
NFKBIAOGDHLBioGRID, IntAct26186194 28514442 details
NFKBIAMCTS1BioGRID, IntAct28514442 details
NFKBIACUEDC1BioGRID, IntAct26186194 28514442 details
NFKBIAPRTFDC1BioGRID, IntAct26186194 28514442 details
NFKBIAARMT1BioGRID, IntAct26186194 28514442 details
NFKBIAANKRD27BioGRID, IntAct26186194 28514442 details
NFKBIASCRN2BioGRID, IntAct26186194 28514442 details
NFKBIAGNPNAT1BioGRID, IntAct28514442 details
NFKBIASPDL1BioGRID, IntAct26186194 28514442 details
NFKBIAAIDABioGRID, IntAct26186194 28514442 details
NFKBIASPECC1LBioGRID, IntAct26186194 28514442 details
NFKBIATBCEBioGRID, IntAct26186194 28514442 details
NFKBIAPLS1BioGRID, IntAct28514442 details
NFKBIAGNG5BioGRID, IntAct26186194 28514442 details
NFKBIARHOABioGRID, IntAct26186194 28514442 details
NFKBIAPOLR2ABioGRID, IntAct26186194 28514442 details
NFKBIATCEA1BioGRID, IntAct26186194 28514442 details
NFKBIADENRBioGRID, IntAct26186194 28514442 details
NFKBIADCAF6BioGRID26186194 details
NFKBIAPOLR2JBioGRID26186194 details
NFKBIAYES1BioGRID26186194 details
NFKBIACTU2BioGRID26186194 details
NFKBIAOTUB1BioGRID26186194 details
NFKBIAMEAK7BioGRID26186194 details
NFKBIAUBFD1BioGRID26186194 details
NFKBIABIRC2BioGRID26186194 details
NFKBIACHAC2BioGRID26186194 details
NFKBIAXPO1BioGRID26673895 details
NFKBIAATXN3BioGRID26496610 details
NFKBIAEGLN3BioGRID26972000 details
NFKBIAFBP1BioGRID32041737 details
NFKBIAHOXB5IntAct23850221 details
NFKBIAHOXB2IntAct23850221 details
NFKBIAHOXD3IntAct23850221 details
NFKBIAHOXA10IntAct23850221 details
NFKBIAIRX3IntAct23850221 details
NFKBIAKLF6IntAct24634218 details
NFKBIAMACROD1IntAct21483817 details
NFKBIACREBBPIntAct21483817 details
NFKBIATNIP2BioGRID27609421 details