Entity Details

Primary name EZH2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15910
EntryNameEZH2_HUMAN
FullNameHistone-lysine N-methyltransferase EZH2
TaxID9606
Evidenceevidence at protein level
Length746
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesEZH2

GO terms

Show/Hide Table
GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000781 chromosome, telomeric region
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0003682 chromatin binding
GO:0003714 transcription corepressor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005677 chromatin silencing complex
GO:0005737 cytoplasm
GO:0006306 DNA methylation
GO:0006325 chromatin organization
GO:0006348 chromatin silencing at telomere
GO:0006355 regulation of transcription, DNA-templated
GO:0008284 positive regulation of cell population proliferation
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0014013 regulation of gliogenesis
GO:0014834 skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
GO:0014898 cardiac muscle hypertrophy in response to stress
GO:0016571 histone methylation
GO:0018024 histone-lysine N-methyltransferase activity
GO:0019058 viral life cycle
GO:0021695 cerebellar cortex development
GO:0021766 hippocampus development
GO:0030183 B cell differentiation
GO:0031490 chromatin DNA binding
GO:0032355 response to estradiol
GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter
GO:0035098 ESC/E(Z) complex
GO:0035984 cellular response to trichostatin A
GO:0036333 hepatocyte homeostasis
GO:0042054 histone methyltransferase activity
GO:0042752 regulation of circadian rhythm
GO:0043021 ribonucleoprotein complex binding
GO:0043406 positive regulation of MAP kinase activity
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0043547 positive regulation of GTPase activity
GO:0045120 pronucleus
GO:0045605 negative regulation of epidermal cell differentiation
GO:0045814 negative regulation of gene expression, epigenetic
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046976 histone methyltransferase activity (H3-K27 specific)
GO:0048387 negative regulation of retinoic acid receptor signaling pathway
GO:0048468 cell development
GO:0048511 rhythmic process
GO:0051154 negative regulation of striated muscle cell differentiation
GO:0070301 cellular response to hydrogen peroxide
GO:0070314 G1 to G0 transition
GO:0070317 negative regulation of G0 to G1 transition
GO:0070734 histone H3-K27 methylation
GO:0070878 primary miRNA binding
GO:0071168 protein localization to chromatin
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0097421 liver regeneration
GO:0098532 histone H3-K27 trimethylation
GO:1900006 positive regulation of dendrite development
GO:1902808 positive regulation of cell cycle G1/S phase transition
GO:1904772 response to tetrachloromethane
GO:1990841 promoter-specific chromatin binding
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle

Subcellular Location

Show/Hide Table
Subcellular Location
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR001005 SANT/Myb domainDomainDomain
IPR001214 SET domainDomainDomain
IPR021654 Histone-lysine N-methyltransferase EZH1/EZH2FamilyFamily
IPR026489 CXC domainDomainDomain
IPR033467 Tesmin/TSO1-like CXC domainDomainDomain
IPR041343 Polycomb repressive complex 2 subunit EZH1/EZH2, tri-helical domainDomainDomain
IPR041355 Pre-SET CXC domainDomainDomain
IPR044439 EZH2, SET domainDomainDomain

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB12887 TazemetostatDrugbanksmall molecule
DB14581 CPI-1205Drugbanksmall molecule

Interactions

162 interactions

InteractorPartnerSourcesPublicationsLink
EZH2_HUMANPHF1_HUMANBioGRID, DIP, HPRD, IntAct, MINT11571280 18285464 18385154 23142980 23273982 24457600 24981860 26496610 27634302 27705803 28068325 29846670 details
EZH2_HUMANDNM3B_HUMANBioGRID, HPRD, IntAct16357870 22094255 24074865 25531315 27728808 details
EZH2_HUMANJIP2_HUMANBioGRID, MINT21900206 details
EZH2_HUMANEED_HUMANBioGRID, DIP, HPRD, IntAct, MINT10581039 11158321 15225548 15385962 15882624 16314526 17937919 18285464 18931660 19026780 19026781 20075857 21078963 21123648 21135039 21190999 22094255 22439931 22897849 23280602 23624935 24320048 24457600 24981860 26344197 26496610 27338022 27634302 27705803 28068325 28320739 29379173 29669287 31527584 31786184 31948940 32296183 9584197 9584199 9742080 details
EZH2_HUMANSUZ12_HUMANBioGRID, DIP, HPRD, IntAct, MINT15882624 16224021 18285464 18453536 18483221 18931660 19026780 19026781 19734898 20075857 20123894 20543829 21123648 21135039 21190999 21378168 21884980 22439931 22939629 23079660 23238014 23624935 23684459 24183680 24320048 24457600 24469040 24981860 25470042 26130719 26344197 26496610 26748827 27303043 27338022 27634302 27705803 27728805 28068325 28514442 29669287 31130994 31281901 31631027 31786184 31948940 details
EZH2_HUMANBRCA1_HUMANBioGRID, MINT23624935 25531315 details
EZH2_HUMANVAV_HUMANBioGRID, HPRD10780782 15882624 8649418 details
EZH2_HUMANUBP7_HUMANBioGRID20800574 27634302 31130994 31866294 32064169 32453339 details
EZH2_HUMANFBXW7_HUMANBioGRID28242758 details
EZH2_HUMANPIN4_HUMANBioGRID, HPRD, IntAct16169070 details
EZH2_HUMANRPN2_HUMANBioGRID, HPRD, IntAct16169070 details
EZH2_HUMANCC85B_HUMANBioGRID, HPRD, IntAct16189514 details
EZH2_HUMANCG025_HUMANBioGRID, MINT21900206 details
EZH2_HUMANDJB11_HUMANBioGRID, MINT21900206 details
EZH2_HUMANADRB2_HUMANIntAct32814053 details
EZH2_HUMANEWS_HUMANBioGRID, IntAct20211142 24457600 details
EZH2_HUMANRELB_HUMANBioGRID21884980 details
EZH2_HUMANTIF1B_HUMANBioGRID24457600 27634302 28068325 32956422 details
EZH2_HUMANAT1A1_HUMANBioGRID, HPRD, IntAct16169070 details
EZH2_HUMANDNMT1_HUMANBioGRID, HPRD, IntAct16357870 21378168 22094255 28068325 31130994 details
EZH2_HUMANDNM3A_HUMANBioGRID, HPRD, IntAct16357870 24074865 details
EZH2_HUMANGA45G_HUMANBioGRID, MINT21900206 details
EZH2_HUMANM3K20_HUMANBioGRID, MINT21900206 details
EZH2_HUMANCSK2B_HUMANBioGRID, IntAct23555304 27634302 details
EZH2_HUMANANDR_HUMANBioGRID, IntAct, MINT22531786 24457600 27728805 30628724 details
EZH2_HUMANJARD2_HUMANBioGRID, DIP, IntAct, MINT20075857 20123894 24457600 24981860 26496610 27634302 27705803 31281901 details
EZH2_HUMANCTNB1_HUMANBioGRID17502350 19661437 27634302 31130994 details
EZH2_HUMANCDK1_HUMANBioGRID20935635 21123648 21131960 21135039 25800736 27716745 details
EZH2_HUMANBC11A_HUMANBioGRID24981860 29263092 details
EZH2_HUMANPSB6_HUMANBioGRID, HPRD, IntAct16169070 details
EZH2_HUMANH31T_HUMANBioGRID21078963 21190999 24457600 details
EZH2_HUMANMED1_HUMANBioGRID17502350 details
EZH2_HUMANCRY2_HUMANBioGRID23555304 details
EZH2_HUMANDPOA2_HUMANBioGRID, HPRD, IntAct16169070 27634302 details
EZH2_HUMANWSB2_HUMANBioGRID, HPRD, IntAct16169070 details
EZH2_HUMANRBBP4_HUMANBioGRID, IntAct, MINT20123894 21123648 24457600 24981860 26496610 27634302 27705803 28068325 details
EZH2_HUMANMYCN_HUMANBioGRID, IntAct23362253 27728805 details
EZH2_HUMANTRI63_HUMANBioGRID, IntAct31391242 details
EZH2_HUMANH11_HUMANBioGRID16431907 details
EZH2_HUMANSPSY_HUMANHPRD, IntAct16169070 details
EZH2_HUMANRIN3_HUMANBioGRID, IntAct25814554 details
EZH2_HUMANKLDC2_HUMANBioGRID, HPRD, IntAct16169070 details
EZH2_HUMANM3K7_HUMANBioGRID, MINT21900206 details
EZH2_HUMANPFD1_HUMANBioGRID, MINT21900206 details
EZH2_HUMANTNF11_HUMANBioGRID, MINT21900206 details
EZH2_HUMANESR1_HUMANBioGRID, IntAct17502350 31527615 details
EZH2_HUMANTAF1D_HUMANBioGRID, MINT21900206 details
EZH2_HUMANCDK6_HUMANBioGRID, IntAct22094256 details
EZH2_HUMANSUV91_HUMANBioGRID, MINT23455924 details
EZH2_HUMANPP1R8_HUMANBioGRID17804093 20671031 details
EZH2_HUMANPJA1_HUMANBioGRID21513699 23688634 details
EZH2_HUMANTF3C1_HUMANBioGRID, HPRD, IntAct16169070 27634302 details
EZH2_HUMANWDR61_HUMANBioGRID, HPRD, IntAct16169070 27634302 details
EZH2_HUMANSIR1_HUMANBioGRID, IntAct15684044 22094255 25800736 details
EZH2_HUMANKDM1A_HUMANBioGRID, MINT23455924 31130994 details
EZH2_HUMANCEP63_HUMANBioGRID, IntAct25416956 31515488 details
EZH2_HUMANSPRE1_HUMANIntAct32814053 details
EZH2_HUMANNINL_HUMANBioGRID, HPRD, IntAct16169070 details
EZH2_HUMANRASA1_HUMANBioGRID, MINT21900206 details
EZH2_HUMANKAT2B_HUMANBioGRID25800736 details
EZH2_HUMANBHE40_HUMANIntAct23555304 details
EZH2_HUMANANM5_HUMANBioGRID, MINT23455924 27634302 details
EZH2_HUMANATRX_HUMANBioGRID, HPRD, IntAct25417162 27634302 9499421 details
EZH2_HUMANKR109_HUMANBioGRID, IntAct32296183 details
EZH2_HUMANH31_HUMANBioGRID16224021 16431907 34079125 details
EZH2_HUMANRBL2_HUMANBioGRID15077161 details
EZH2_HUMANZRAN1_HUMANBioGRID29669287 details
EZH2_HUMANMUC1_HUMANBioGRID28785086 details
EZH2_HUMANSMN_HUMANBioGRID, MINT21900206 details
EZH2_HUMANAKT1_HUMANBioGRID, HPRD16224021 details
EZH2_HUMANTF65_HUMANBioGRID21884980 details
EZH2_HUMANUBP1_HUMANBioGRID30425057 details
EZH2_HUMANMAPK3_HUMANBioGRID, MINT21900206 details
EZH2_HUMANEPC1_HUMANBioGRID15536069 details
EZH2_HUMANKS6A5_HUMANBioGRID, MINT21900206 details
EZH2_HUMANPHB2_HUMANBioGRID17453341 details
EZH2_HUMANAT1B1_HUMANBioGRID, MINT21900206 details
EZH2_HUMANKITH_HUMANBioGRID, MINT21900206 details
EZH2_HUMANMELK_HUMANBioGRID31434700 details
EZH2_HUMANTRI55_HUMANBioGRID, IntAct31391242 details
EZH2_HUMANPRD14_HUMANBioGRID23280602 details
EZH2_HUMANCLAT_HUMANIntAct32814053 details
EZH2_HUMANLATS2_HUMANBioGRID27434182 details
EZH2_HUMANFGFR3_HUMANIntAct32814053 details
EZH2_HUMANCDK2_HUMANBioGRID20935635 details
EZH2_HUMANJAK2_HUMANBioGRID24469040 details
EZH2_HUMANHDAC3_HUMANBioGRID, IntAct21685935 23079660 details
EZH2_HUMANMTF2_HUMANBioGRID, IntAct, MINT20123894 24457600 24981860 27634302 27705803 details
EZH2_HUMANEZH1_HUMANBioGRID19026780 19026781 24981860 27634302 details
EZH2_HUMANWT1_HUMANBioGRID21378168 details
EZH2_HUMANUHRF1_HUMANBioGRID22330138 27634302 details
EZH2_HUMANHDAC1_HUMANBioGRID, HPRD, IntAct10581039 15520282 21685935 22439931 24771265 26344197 31130994 details
EZH2_HUMANE2F1_HUMANBioGRID, IntAct23238014 24771265 details
EZH2_HUMANAEBP2_HUMANBioGRID, DIP, IntAct, MINT24457600 24981860 26186194 26496610 27634302 27705803 28068325 28514442 29348366 31281901 details
EZH2_HUMANCHD4_HUMANBioGRID24981860 26344197 28068325 28486105 details
EZH2_HUMANUBP44_HUMANBioGRID29669287 30622230 details
EZH2_HUMANRARA_HUMANBioGRID, IntAct17560333 details
EZH2_HUMANHLX_HUMANMINT23455154 details
EZH2_HUMANSSX2_HUMANBioGRID22439931 details
EZH2_HUMANDDX5_HUMANBioGRID24457600 27338022 details
EZH2_HUMANRB_HUMANBioGRID24771265 details
EZH2_HUMANFBW1A_HUMANBioGRID, IntAct24469040 28514442 details
EZH2_HUMANPHF19_HUMANBioGRID, IntAct, MINT21143197 23104054 24457600 24981860 27634302 27705803 28514442 details
EZH2_HUMANHDAC2_HUMANBioGRID10581039 21685935 24981860 26344197 details
EZH2_HUMANE2F6_HUMANBioGRID, HPRD15536069 16565076 details
EZH2_HUMANZBT16_HUMANBioGRID28223321 29425303 details
EZH2_HUMANMYC_HUMANBioGRID, IntAct22094255 23079660 24771265 details
EZH2_HUMANZMY11_HUMANBioGRID, HPRD16565076 details
EZH2_HUMANKDM5A_HUMANBioGRID18483221 details
EZH2_HUMANPCGF1_HUMANBioGRID26687479 details
EZH2_HUMANSMCA2_HUMANBioGRID28068325 details
EZH2_HUMANSMRC1_HUMANBioGRID27634302 28068325 details
EZH2_HUMANSNUT2_HUMANBioGRID29669287 details
EZH2_HUMANSP16H_HUMANBioGRID27634302 888800000289 details
EZH2_HUMANSTAT3_HUMANIntAct23684459 details
EZH2_HUMANKMT5A_HUMANBioGRID12351676 details
EZH2_HUMANZN263_HUMANBioGRID32051553 details
EZH2_HUMANF16P1_HUMANBioGRID31948940 details
EZH2_HUMANASXL1_HUMANBioGRID, IntAct22897849 details
EZH2_HUMANCUL1_HUMANBioGRID24469040 details
EZH2_HUMANGATA4_HUMANBioGRID, IntAct22094255 22215809 details
EZH2_HUMANSNAI1_HUMANBioGRID18519590 21685935 24903147 details
EZH2_HUMANTRI37_HUMANBioGRID25470042 details
EZH2_HUMANKDM2B_HUMANBioGRID19202064 details
EZH2_HUMANSMRC2_HUMANBioGRID27634302 28068325 details
EZH2_HUMANSMUF2_HUMANBioGRID30649914 31948940 details
EZH2_HUMANUBP36_HUMANBioGRID31434700 details
EZH2_HUMANNCOA1_HUMANBioGRID17502350 details
EZH2_HUMANARI1A_HUMANBioGRID27634302 28068325 details
EZH2_HUMANBRD4_HUMANBioGRID27634302 888800000289 details
EZH2_HUMANHS90A_HUMANBioGRID28914785 details
EZH2_HUMANUBP53_HUMANBioGRID29669287 details
EZH2_HUMANPAXB1_HUMANBioGRID27634302 details
EZH2_HUMANCUL4B_HUMANBioGRID, IntAct23238014 24292684 27634302 details
EZH2_HUMANDISC1_HUMANIntAct31413325 details
EZH2_HUMANRUNX3_HUMANBioGRID20714105 details
EZH2_HUMANRORA_HUMANBioGRID23063525 details
EZH2_HUMANDDB2_HUMANBioGRID26130719 details
EZH2_HUMANSMCA4_HUMANBioGRID27634302 28068325 details
EZH2_HUMANMDM4_HUMANBioGRID32427989 details
EZH2_HUMANTYY1_HUMANBioGRID11158321 15520282 details
EZH2_HUMANMDM2_HUMANBioGRID26748827 32427989 details
EZH2_HUMANBMI1_HUMANIntAct23238014 23540691 details
EZH2_HUMANSALL4_HUMANBioGRID27634302 details
EZH2_HUMANCDYL_HUMANBioGRID22009739 details
EZH2_HUMANHIC1_HUMANBioGRID22315224 details
EZH2_HUMANHNF4A_HUMANBioGRID25391650 details
EZH2_HUMANCTCF_HUMANBioGRID31917284 details
EZH2_HUMANSSXT_HUMANBioGRID22439931 details
EZH2_HUMANPB1_HUMANBioGRID27634302 28940253 details
EZH2_HUMANMYOD1_HUMANBioGRID15520282 details
EZH2_HUMANBACH1_HUMANBioGRID30891497 details
EZH2_HUMANEZH2_HUMANBioGRID19026781 details
EZH2_HUMANCHIP_HUMANBioGRID28320739 details
EZH2_HUMANZN281_HUMANBioGRID27634302 details
EZH2_HUMANARM12_HUMANBioGRID30026490 details
EZH2_HUMANEZHIP_HUMANBioGRID31281901 details
EZH2_HUMANFOXM1_HUMANBioGRID27303043 details
EZH2_HUMANUBP22_HUMANBioGRID29669287 details
EZH2_HUMANUBP49_HUMANBioGRID29669287 details
EZH2_HUMANSMAD2_HUMANBioGRID31130994 details
EZH2_HUMANSMAD4_HUMANBioGRID31130994 details