Entity Details

Primary name LEF1
Entity type gene
Source Source Link

Details

PrimaryID51176
RefseqGeneNG_015798
SymbolLEF1
Namelymphoid enhancer binding factor 1
Chromosome4
Location4q25
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2001-05-08
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsLEF1_HUMAN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001569 branching involved in blood vessel morphogenesis
GO:0001649 osteoblast differentiation
GO:0001756 somitogenesis
GO:0001837 epithelial to mesenchymal transition
GO:0002040 sprouting angiogenesis
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007223 Wnt signaling pathway, calcium modulating pathway
GO:0008013 beta-catenin binding
GO:0008284 positive regulation of cell population proliferation
GO:0008301 DNA binding, bending
GO:0010628 positive regulation of gene expression
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0021542 dentate gyrus development
GO:0021861 forebrain radial glial cell differentiation
GO:0021873 forebrain neuroblast division
GO:0021943 formation of radial glial scaffolds
GO:0022408 negative regulation of cell-cell adhesion
GO:0022409 positive regulation of cell-cell adhesion
GO:0030111 regulation of Wnt signaling pathway
GO:0030223 neutrophil differentiation
GO:0030284 estrogen receptor activity
GO:0030326 embryonic limb morphogenesis
GO:0030331 estrogen receptor binding
GO:0030335 positive regulation of cell migration
GO:0030509 BMP signaling pathway
GO:0030851 granulocyte differentiation
GO:0030854 positive regulation of granulocyte differentiation
GO:0030879 mammary gland development
GO:0032696 negative regulation of interleukin-13 production
GO:0032713 negative regulation of interleukin-4 production
GO:0032714 negative regulation of interleukin-5 production
GO:0032993 protein-DNA complex
GO:0033153 T cell receptor V(D)J recombination
GO:0042100 B cell proliferation
GO:0042393 histone binding
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042826 histone deacetylase binding
GO:0043066 negative regulation of apoptotic process
GO:0043392 negative regulation of DNA binding
GO:0043565 sequence-specific DNA binding
GO:0043586 tongue development
GO:0043923 positive regulation by host of viral transcription
GO:0043966 histone H3 acetylation
GO:0043967 histone H4 acetylation
GO:0045063 T-helper 1 cell differentiation
GO:0045295 gamma-catenin binding
GO:0045588 positive regulation of gamma-delta T cell differentiation
GO:0045843 negative regulation of striated muscle tissue development
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048341 paraxial mesoderm formation
GO:0050909 sensory perception of taste
GO:0060033 anatomical structure regression
GO:0060070 canonical Wnt signaling pathway
GO:0060260 regulation of transcription initiation from RNA polymerase II promoter
GO:0060325 face morphogenesis
GO:0060326 cell chemotaxis
GO:0060710 chorio-allantoic fusion
GO:0061153 trachea gland development
GO:0062009 secondary palate development
GO:0070016 armadillo repeat domain binding
GO:0070742 C2H2 zinc finger domain binding
GO:0071345 cellular response to cytokine stimulus
GO:0071353 cellular response to interleukin-4
GO:0071864 positive regulation of cell proliferation in bone marrow
GO:0071866 negative regulation of apoptotic process in bone marrow cell
GO:0071899 obsolete negative regulation of estrogen receptor binding
GO:0090068 positive regulation of cell cycle process
GO:1902262 apoptotic process involved in blood vessel morphogenesis
GO:1904837 beta-catenin-TCF complex assembly
GO:1990837 sequence-specific double-stranded DNA binding
GO:1990907 beta-catenin-TCF complex

Diseases

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Interactions

62 interactions

InteractorPartnerSourcesPublicationsLink
LEF1TLE1BioGRID, HPRD, IntAct15768032 9751710 details
LEF1DPYSL2BioGRID, IntAct21988832 details
LEF1CTNNB1bhf-ucl, BioGRID, DIP, HPRD, I2D, IntAct, Molecular Connections10890911 10958684 11751639 11835406 12077367 12556497 12748295 15525529 15684397 15728254 15768032 16204248 16510874 16510875 17510365 17517646 18077326 18296023 19223551 20123964 21743491 22014570 27684187 29374064 29540185 8757136 9419974 details
LEF1AURKABioGRID, MINT24412244 details
LEF1BAXBioGRID, MINT24412244 details
LEF1BUB1BioGRID, MINT24412244 details
LEF1MLH1BioGRID, MINT24412244 details
LEF1MLH3BioGRID, MINT24412244 details
LEF1MSH2BioGRID, MINT24412244 details
LEF1NRASBioGRID, MINT24412244 details
LEF1RB1BioGRID, MINT24412244 details
LEF1STK11BioGRID, MINT24412244 details
LEF1MLLT11IntAct26079538 details
LEF1NFE2L2IntAct32911434 details
LEF1PIAS4BioGRID, HPRD11731474 details
LEF1MITFBioGRID, HPRD12032083 12048204 details
LEF1EP300BioGRID, HPRD12446687 details
LEF1ALYREFBioGRID, HPRD9119228 details
LEF1NOTCH1BioGRID, HPRD11604490 details
LEF1NLKBioGRID, HPRD12556497 12901858 20194509 24394665 details
LEF1SMAD2BioGRID, HPRD10890911 15750622 details
LEF1SMAD3BioGRID, HPRD10890911 15750622 details
LEF1SMAD4BioGRID, HPRD10890911 details
LEF1KMT5ABioGRID21282610 details
LEF1TLE2BioGRID15768032 details
LEF1CDX1BioGRID, HPRD15143193 details
LEF1PITX2BioGRID, HPRD15728254 details
LEF1RNF138BioGRID16714285 27195665 details
LEF1KPNA2HPRD8631802 details
LEF1KPNA1HPRD8631802 details
LEF1TCF7L2BioGRID, IntAct22014570 24748645 details
LEF1IGF1RMINT22261717 details
LEF1JUPbhf-ucl14661054 details
LEF1FHITBioGRID, DIP18077326 details
LEF1SMAD7BioGRID15684397 15750622 details
LEF1UBTFBioGRID, HPRD12748295 details
LEF1RUVBL1BioGRID9843967 details
LEF1DAZAP2BioGRID19304756 details
LEF1DACT1BioGRID18936100 details
LEF1HDAC1BioGRID10958684 details
LEF1E2F1BioGRID17980157 details
LEF1MYBBioGRID21795403 details
LEF1HINT1BioGRID16014379 details
LEF1STAT5ABioGRID24394665 details
LEF1NARFBioGRID24394665 details
LEF1RNF14BioGRID23449499 details
LEF1SMAD1BioGRID, HPRD10890911 15750622 details
LEF1PJA2BioGRID30021253 details
LEF1SUMO2HPRD11731474 details
LEF1RUNX2HPRD12551949 details
LEF1ALX4HPRD11696550 details
LEF1TCF4I2D21743491 details
LEF1EGR1I2D21743491 details
LEF1PRMT6BioGRID, IntAct26186194 28514442 details
LEF1VDRDIP17517646 details
LEF1NFATC1BioGRID27637333 details
LEF1NFATC2BioGRID27637333 details
LEF1EGLN3BioGRID26972000 details
LEF1FOXM1IntAct22014570 details
LEF1CD44IntAct26079538 details
LEF1TNFSF4IntAct33179750 details
LEF1TNIP2BioGRID27609421 details