Entity Details

Primary name FRDA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ16595
EntryNameFRDA_HUMAN
FullNameFrataxin, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length210
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesFXN

GO terms

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GOName
GO:0004322 ferroxidase activity
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0006119 oxidative phosphorylation
GO:0006783 heme biosynthetic process
GO:0006811 ion transport
GO:0006879 cellular iron ion homeostasis
GO:0007005 mitochondrion organization
GO:0007628 adult walking behavior
GO:0008198 ferrous iron binding
GO:0008199 ferric iron binding
GO:0008284 positive regulation of cell population proliferation
GO:0009060 aerobic respiration
GO:0009792 embryo development ending in birth or egg hatching
GO:0010039 response to iron ion
GO:0010722 regulation of ferrochelatase activity
GO:0016226 iron-sulfur cluster assembly
GO:0016540 protein autoprocessing
GO:0018283 iron incorporation into metallo-sulfur cluster
GO:0019230 proprioception
GO:0030307 positive regulation of cell growth
GO:0034986 iron chaperone activity
GO:0040015 negative regulation of multicellular organism growth
GO:0043066 negative regulation of apoptotic process
GO:0043085 positive regulation of catalytic activity
GO:0046621 negative regulation of organ growth
GO:0051349 positive regulation of lyase activity
GO:0051537 2 iron, 2 sulfur cluster binding
GO:0070301 cellular response to hydrogen peroxide
GO:0090201 negative regulation of release of cytochrome c from mitochondria
GO:1904231 positive regulation of succinate dehydrogenase activity
GO:1904234 positive regulation of aconitate hydratase activity
GO:1990221 L-cysteine desulfurase complex

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion

Domains

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DomainNameCategoryType
IPR002908 Frataxin/CyaYFamilyFamily
IPR017789 FrataxinFamilyFamily
IPR020895 Frataxin conserved siteSiteConserved site
IPR036524 Frataxin/CyaY superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01592 IronDrugbanksmall molecule
DB14488 Ferrous gluconateDrugbanksmall molecule
DB14489 Ferrous succinateDrugbanksmall molecule
DB14490 Ferrous ascorbateDrugbanksmall molecule
DB14491 Ferrous fumarateDrugbanksmall molecule
DB14501 Ferrous glycine sulfateDrugbanksmall molecule