Entity Details

Primary name PRSS8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ16651
EntryNamePRSS8_HUMAN
FullNameProstasin
TaxID9606
Evidenceevidence at protein level
Length343
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesPRSS8

GO terms

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GOName
GO:0004252 serine-type endopeptidase activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0008236 serine-type peptidase activity
GO:0010765 positive regulation of sodium ion transport
GO:0016021 integral component of membrane
GO:0017080 sodium channel regulator activity
GO:0070062 extracellular exosome
GO:0070268 cornification

Subcellular Location

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Subcellular Location
Cell membrane
Secreted

Domains

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DomainNameCategoryType
IPR001254 Serine proteases, trypsin domainDomainDomain
IPR001314 Peptidase S1A, chymotrypsin familyFamilyFamily
IPR009003 Peptidase S1, PA clanFamilyHomologous superfamily
IPR018114 Serine proteases, trypsin family, histidine active siteSiteActive site
IPR033116 Serine proteases, trypsin family, serine active siteSiteActive site
IPR043504 Peptidase S1, PA clan, chymotrypsin-like foldFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB06900 1-[4-(hydroxymethyl)phenyl]guanidineDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
PRSS8_HUMANMCAF1_HUMANHPRD, MINT15231748 details
PRSS8_HUMANS13A1_HUMANBioGRID18407958 details