Entity Details

Primary name KYNU_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ16719
EntryNameKYNU_HUMAN
FullNameKynureninase
TaxID9606
Evidenceevidence at protein level
Length465
SequenceStatuscomplete
DateCreated1998-12-15
DateModified2021-06-02

Ontological Relatives

GenesKYNU

GO terms

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GOName
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006569 tryptophan catabolic process
GO:0007568 aging
GO:0009435 NAD biosynthetic process
GO:0019441 tryptophan catabolic process to kynurenine
GO:0019442 tryptophan catabolic process to acetyl-CoA
GO:0019805 quinolinate biosynthetic process
GO:0030170 pyridoxal phosphate binding
GO:0030429 kynureninase activity
GO:0034341 response to interferon-gamma
GO:0034354 'de novo' NAD biosynthetic process from tryptophan
GO:0034516 response to vitamin B6
GO:0042803 protein homodimerization activity
GO:0043420 anthranilate metabolic process
GO:0061981 3-hydroxykynureninase activity
GO:0097053 L-kynurenine catabolic process

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000192 Aminotransferase class V domainDomainDomain
IPR010111 KynureninaseFamilyFamily
IPR015421 Pyridoxal phosphate-dependent transferase, major domainFamilyHomologous superfamily
IPR015422 Pyridoxal phosphate-dependent transferase, small domainFamilyHomologous superfamily
IPR015424 Pyridoxal phosphate-dependent transferaseFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00114 Pyridoxal phosphateDrugbanksmall molecule
DB00160 AlanineDrugbanksmall molecule
DB07069 m-Hydroxyhippuric acidDrugbanksmall molecule

Interactions

9 interactions