Entity Details

Primary name PPP3CA
Entity type gene
Source Source Link

Details

PrimaryID5530
RefseqGene
SymbolPPP3CA
Nameprotein phosphatase 3 catalytic subunit alpha
Chromosome4
Location4q24
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-24
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsPP2BA_HUMAN

GO terms

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GOName
GO:0000082 G1/S transition of mitotic cell cycle
GO:0001975 response to amphetamine
GO:0004722 protein serine/threonine phosphatase activity
GO:0005509 calcium ion binding
GO:0005516 calmodulin binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005955 calcineurin complex
GO:0006470 protein dephosphorylation
GO:0006606 protein import into nucleus
GO:0006816 calcium ion transport
GO:0007223 Wnt signaling pathway, calcium modulating pathway
GO:0007420 brain development
GO:0007568 aging
GO:0014883 transition between fast and slow fiber
GO:0014898 cardiac muscle hypertrophy in response to stress
GO:0016018 cyclosporin A binding
GO:0016311 dephosphorylation
GO:0019897 extrinsic component of plasma membrane
GO:0019899 enzyme binding
GO:0030018 Z disc
GO:0030335 positive regulation of cell migration
GO:0033173 calcineurin-NFAT signaling cascade
GO:0033192 calmodulin-dependent protein phosphatase activity
GO:0033555 multicellular organismal response to stress
GO:0035562 negative regulation of chromatin binding
GO:0036057 slit diaphragm
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042060 wound healing
GO:0042110 T cell activation
GO:0042383 sarcolemma
GO:0043197 dendritic spine
GO:0043403 skeletal muscle tissue regeneration
GO:0044877 protein-containing complex binding
GO:0045785 positive regulation of cell adhesion
GO:0045807 positive regulation of endocytosis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046676 negative regulation of insulin secretion
GO:0046983 protein dimerization activity
GO:0048741 skeletal muscle fiber development
GO:0050774 negative regulation of dendrite morphogenesis
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051117 ATPase binding
GO:0051592 response to calcium ion
GO:0060079 excitatory postsynaptic potential
GO:0070262 peptidyl-serine dephosphorylation
GO:0071333 cellular response to glucose stimulus
GO:0097720 calcineurin-mediated signaling
GO:0098685 Schaffer collateral - CA1 synapse
GO:0098978 glutamatergic synapse
GO:0099170 postsynaptic modulation of chemical synaptic transmission
GO:0106306 protein serine phosphatase activity
GO:0106307 protein threonine phosphatase activity
GO:1903244 positive regulation of cardiac muscle hypertrophy in response to stress
GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA
GO:1905205 positive regulation of connective tissue replacement

Diseases

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Interactions

119 interactions

InteractorPartnerSourcesPublicationsLink
PPP3CAGRB2BioGRID, IntAct, MINT12577067 17474147 21900206 details
PPP3CAC16orf74BioGRID, HPRD, IntAct16189514 21516116 25416956 32296183 details
PPP3CAPPP3R1BioGRID, DIP, HPRD, IntAct, MINT11439183 19896943 21516116 22343722 22939629 23468591 24954618 25416956 26186194 26264872 26871637 27880917 28514442 32296183 32814053 8524402 details
PPP3CAABL1IntAct17474147 details
PPP3CALASP1IntAct22665060 details
PPP3CAJUNBioGRID, MINT17215518 25609649 details
PPP3CASHANK2BioGRID, IntAct32296183 details
PPP3CAAMPHBioGRID, IntAct32296183 details
PPP3CAARMT1BioGRID, IntAct26344197 27880917 32296183 details
PPP3CATNS4BioGRID, IntAct32296183 details
PPP3CATRIM72BioGRID, IntAct32296183 details
PPP3CAITPKBBioGRID, IntAct32296183 details
PPP3CAABI2BioGRID, IntAct32296183 details
PPP3CAUNC119BioGRID, IntAct32296183 details
PPP3CAAKAP5BioGRID, DIP, HPRD, IntAct22343722 32296183 7528941 9765270 details
PPP3CAFAM167ABioGRID, IntAct32296183 details
PPP3CANFATC1BioGRID, DIP, IntAct23468591 24954618 28514442 details
PPP3CARCAN2BioGRID, HPRD, IntAct10861295 12102656 26186194 28514442 details
PPP3CARCAN1BioGRID, HPRD, IntAct10861295 12063245 23118980 26186194 27880917 28514442 details
PPP3CANFATC2DIP24954618 details
PPP3CAAATKBioGRID, MINT28065597 details
PPP3CAERBB3MINT28065597 details
PPP3CAFGFR4BioGRID, MINT28065597 details
PPP3CARYKBioGRID, MINT28065597 details
PPP3CAPTK7BioGRID, MINT28065597 details
PPP3CASOD1HPRD, IntAct11513882 32814053 details
PPP3CACABIN1BioGRID, HPRD11714752 9655484 details
PPP3CAMYOZ2BioGRID, HPRD11114196 11842093 details
PPP3CAPSMA6BioGRID21420386 details
PPP3CAKCNIP3BioGRID17102134 details
PPP3CAMARCHF7BioGRID24905733 details
PPP3CAUBE4BBioGRID29326975 details
PPP3CAKLHL3BioGRID30718414 details
PPP3CASLC6A4BioGRID24107951 details
PPP3CAPLAC8BioGRID32296183 details
PPP3CAPPP3R2BioGRID32296183 details
PPP3CASNCABioGRID29409956 details
PPP3CAOGTBioGRID32994395 details
PPP3CASTUB1BioGRID29326975 details
PPP3CAUSP14MINT19896943 details
PPP3CANR3C1IntAct20195357 details
PPP3CARXRBIntAct20195357 details
PPP3CAUTRNDIP18838687 details
PPP3CADISC1IntAct31413325 details
PPP3CAPPIABioGRID12218175 details
PPP3CAADRB2BioGRID9880537 details
PPP3CABCL2BioGRID, HPRD19706527 7593193 9109491 details
PPP3CAMYOZ1BioGRID11114196 details
PPP3CAAKT1BioGRID20605778 details
PPP3CAPHLPP2BioGRID20605778 details
PPP3CAPTENBioGRID20605778 details
PPP3CAPDE4DBioGRID20647544 details
PPP3CATRAF3BioGRID22715070 details
PPP3CACRTC2BioGRID, HPRD15454081 27990298 details
PPP3CAPPP3CAHPRD12574411 details
PPP3CAGABRA1HPRD12574411 details
PPP3CAGABRG2HPRD12574411 details
PPP3CAPRKCZHPRD12021260 details
PPP3CAFKBP1AHPRD7543369 8524402 details
PPP3CAGABRB2HPRD12574411 details
PPP3CACASP3HPRD11478781 details
PPP3CAFKBP8HPRD12510191 15757646 details
PPP3CASYNJ1HPRD14704270 details
PPP3CAMYOZ3HPRD11842093 details
PPP3CABADHPRD10195903 details
PPP3CAATP2B4HPRD15955804 details
PPP3CAIRF2BioGRID, IntAct21903422 details
PPP3CAKLRG2BioGRID, IntAct28514442 details
PPP3CANFATC4BioGRID, IntAct26186194 28514442 details
PPP3CASIK3BioGRID, IntAct26186194 28514442 details
PPP3CAPDHBBioGRID, IntAct26186194 28514442 details
PPP3CADEFA1BioGRID, IntAct28514442 details
PPP3CADEFA1BIntAct28514442 details
PPP3CATMEM200ABioGRID, IntAct28514442 details
PPP3CARCAN3BioGRID, IntAct26186194 28514442 details
PPP3CASMPD3BioGRID, IntAct28514442 details
PPP3CAPABIR1BioGRID, IntAct26186194 28514442 details
PPP3CARASSF2BioGRID, IntAct26186194 28514442 details
PPP3CANUDCD1MINT29021621 details
PPP3CAGSK3BBioGRID, IntAct29568061 details
PPP3CAPRNPBioGRID, UniProt29791485 details
PPP3CASH3KBP1BioGRID, IntAct31980649 details
PPP3CAELK1BioGRID, IntAct31980649 details
PPP3CAGRB10BioGRID, IntAct31980649 details
PPP3CAMRI1BioGRID22939629 details
PPP3CARHOCBioGRID22939629 details
PPP3CAMAPK7BioGRID23428871 details
PPP3CAHNRNPH1BioGRID22863883 details
PPP3CAP3H1BioGRID22863883 details
PPP3CASETSIPBioGRID22863883 details
PPP3CAMAT2BBioGRID22863883 details
PPP3CANASPBioGRID22863883 details
PPP3CANRDCBioGRID22863883 details
PPP3CAPDIA6BioGRID22863883 details
PPP3CAPFDN5BioGRID22863883 details
PPP3CAPPP2R2ABioGRID22863883 details
PPP3CATNPO3BioGRID22863883 details
PPP3CATNPO1BioGRID22863883 details
PPP3CATSNBioGRID22863883 details
PPP3CAVBP1BioGRID22863883 details
PPP3CAXPO5BioGRID22863883 details
PPP3CACEP76BioGRID23443559 details
PPP3CATP53BioGRID23443559 details
PPP3CAVCPBioGRID23443559 details
PPP3CAARFIP1BioGRID26344197 details
PPP3CAPSMD9BioGRID26344197 details
PPP3CALBHBioGRID27880917 details
PPP3CANCAPGBioGRID27880917 details
PPP3CATUBA1BBioGRID27880917 details
PPP3CATARDBPBioGRID29715546 details
PPP3CARECQL4BioGRID29229926 details
PPP3CAPLEKHA4BioGRID31091453 details
PPP3CAMAGEA3BioGRID31267705 details
PPP3CAANKRD55BioGRID31620119 details
PPP3CACHMP4BBioGRID31586073 details
PPP3CAECT2BioGRID31586073 details
PPP3CAHNRNPLBioGRID28611215 details
PPP3CAVIRMABioGRID29507755 details
PPP3CADDX58BioGRID32513696 details